Silofast

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What Silofast is and how it works

Silofast contains silodosin, a uroselective alpha-1A adrenoceptor antagonist. The smooth muscle of the prostate, prostatic urethra and bladder neck is rich in alpha-1A receptors; blocking them relaxes that muscle and improves urine flow. Because silodosin is >100 times more selective for alpha-1A than alpha-1B receptors, blood-pressure effects are smaller than with non-selective alpha-blockers such as terazosin or doxazosin.

Silofast is licensed to relieve lower urinary tract symptoms (LUTS) of benign prostatic hyperplasia — weak stream, hesitancy, intermittency, incomplete emptying, frequency, urgency and nocturia — in adult men. It does δεν shrink the prostate; if shrinkage is needed (large gland, high PSA, recurrent retention) a 5-alpha-reductase inhibitor such as dutasteride or finasteride is added.

Dose and how to take it

Take with food at the same meal each day — food increases tolerability and gives a more predictable plasma level. Swallow whole; do not crush. Onset of symptom benefit is rapid (within days for flow rate) but the full effect takes 2–4 weeks. If you miss a dose, skip it and take the next one as scheduled — do not double up.

Παρενέργειες

Αλληλεπιδράσεις φαρμάκων

Who should not take Silofast

• Severe renal impairment (eGFR <30 mL/min) — not studied; avoid
• Σοβαρή ηπατική δυσλειτουργία (Child-Pugh C)
• Concurrent strong CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin)
• History of severe orthostatic hypotension
• Women, children, adolescents (no indication; not studied)

Pregnancy, fertility and storage

Silofast is not used in women and is not for paediatric use. Because of retrograde ejaculation in >25% of users, men actively trying to father a child should discuss alternatives or temporarily switch to tamsulosin (slightly lower retrograde-ejaculation rate) with their prescriber. Store below 30°C in the original blister.

Συχνές Ερωτήσεις

How quickly does Silofast start working?

Flow-rate improvement is measurable within 2–6 hours of the first dose, but daily symptom relief stabilises over 2–4 weeks. Most men notice clearer night-time relief within the first week.

Why is the dose taken with food?

Food modestly slows absorption and lowers peak plasma levels — this reduces dizziness without compromising efficacy. Taking it at the same meal each day keeps levels predictable.

What is retrograde ejaculation and is it dangerous?

Retrograde ejaculation means semen flows backwards into the bladder rather than out. It looks like a “dry orgasm”, is not harmful and reverses fully within a few days of stopping silodosin. It does temporarily affect fertility.

Will Silofast shrink my prostate?

No. Silodosin only relaxes the smooth muscle of the prostate and bladder neck. It improves flow, not size. If the gland is large or PSA is rising, your urologist may add finasteride or dutasteride.

Can I take Silofast with tadalafil 5 mg for BPH and ED?

The combination is widely used and effective, but can amplify blood-pressure lowering. Start one drug, become stable, then add the second — do not start both simultaneously. Tell your prescriber about all PDE-5 use.

Why is the eye-surgery warning so important?

Once silodosin has bound iris-dilator alpha-1A receptors, the iris can become floppy even after the drug is stopped. So all cataract / glaucoma surgeons need to know in advance — they may use special surgical techniques to keep the iris stable.

What if I forget a dose?

Skip the missed dose and take the next one at the usual time with food. Do not take two doses in one day — that increases the risk of dizziness and fainting.

Is silodosin better than tamsulosin?

Silodosin has higher alpha-1A selectivity, which usually means lower BP impact but a higher rate of retrograde ejaculation. Tamsulosin has slightly more orthostatic dizziness but lower ejaculatory side effects. Comparator trials show similar IPSS improvement.

Can I drink alcohol on Silofast?

Modest amounts are usually fine, but alcohol amplifies dizziness on standing. Avoid alcohol with the very first dose and for the first week of treatment.

Do I need ongoing PSA / prostate monitoring?

Yes. Silodosin treats symptoms, not the underlying gland. Continue routine PSA, DRE and IPSS reviews at the interval your urologist recommends — typically every 6–12 months.

Other Bladder & Prostate Medications

• Alfusin (alfuzosin 10 mg ER) — alpha-blocker, fewer ejaculatory side effects
• Alfusin D (alfuzosin + dutasteride) — combination if your gland is large
• Urotel XL (tolterodine ER) — if storage symptoms (frequency / urgency) dominate
• Cystone — herbal urinary support for stones / mild LUTS
• Fosirol 3 g (fosfomycin) — for an acute UTI episode

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