Tretin Cream
✅ Reduces Acne Breakouts
✅ Promotes Skin Renewal
✅ Lightens Skin Discoloration
✅ Minimizes Fine Lines
✅ Improves Skin Texture
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
💡 Quick Answer — What is Tretin Cream?
Tretin Cream contains tretinoin 0.025% or 0.05% — a topical retinoid (vitamin A derivative) for mild-to-moderate acne vulgaris, photoageing (fine lines, uneven tone), and post-inflammatory hyperpigmentation. Apply a pea-sized amount at bedtime to clean dry skin. Start 2–3 nights per week for the first 2 weeks; increase frequency as the skin acclimates. Use SPF 30+ daily. Visible improvement takes 8–12 weeks. Initial flare (“retinoid purge”) at weeks 2–4 is normal — do not stop unless severe.
📦 Κάθε παραγγελία καλύπτεται από την Πολιτική Εγγύησης Επαναποστολής — εάν το δέμα σας δεν φτάσει εντός 20 εργάσιμων ημερών, το επαναποστέλλουμε.
Γιατί να παραγγείλετε από τη MedsBase
Τα γενόσημα φάρμακά μας προέρχονται από κατασκευαστές που πιστοποιούνται από την WHO-GMP και αποστέλλονται παγκοσμίως σε διακριτική, απλή συσκευασία — χωρίς όνομα φαρμάκου στο εξωτερικό του δέματος. Οι πληρωμές με κάρτα δρομολογούνται μέσω ρυθμισμένου επεξεργαστή (οι περιγραφές εκκαθάρισης περιλαμβάνουν ρυθμισμένο επεξεργαστή πληρωμών με κάρτα — ποτέ “MedsBase” ή οποιοδήποτε όνομα φαρμάκου). Γίνονται δεκτές και πληρωμές με κρυπτονομίσματα και τραπεζική μεταφορά SEPA. Κάθε παραγγελία καλύπτεται από την Πολιτική Επαναποστολής Εξασφαλίσεώς μας.
Γιατί να παραγγείλετε από τη MedsBase
Choosing Tretin Cream from MedsBase:
- WHO-GMP certified manufacturer — sourced from a regulated facility, finished pack with batch number and expiry.
- Διακριτική συσκευασία — plain envelope, no medication name on the outside.
- Παγκόσμια αποστολή with Reshipment Assurance — if your parcel does not arrive within 20 business days we re-ship at no cost (subject to policy terms).
- Loyalty points — 1 point per $1 spent (excludes peptides); 100 points = $5 off.
What Tretin Cream is and how it works
Tretin Cream contains tretinoin 0.025% or 0.05%. Tretinoin (all-trans retinoic acid) binds nuclear retinoic acid receptors (RAR-α/β/γ) in keratinocytes, regulating transcription of genes that control cell turnover, sebum production, and dermal collagen synthesis. The result: faster shedding of comedone-forming corneocytes, reduced sebum, normalised follicular keratinisation, and over months, increased dermal collagen and improved photoageing. Manufacturer: Pulse Pharma (WHO-GMP certified).
Indications
- Mild-to-moderate acne vulgaris — first-line topical for comedonal and inflammatory acne.
- Photoageing — fine lines, uneven pigmentation, roughness, dullness from cumulative UV exposure.
- Post-inflammatory hyperpigmentation (PIH) — dark spots after acne or trauma.
- Melasma — adjunct in Kligman triple combinations.
- Keratosis pilaris — off-label for stubborn cases.
How to apply
| Step | Detail |
|---|---|
| Cleanse | Wash with a gentle non-foaming cleanser. Pat dry. Wait 10–15 minutes — applying tretinoin to damp skin amplifies irritation. |
| Amount | Pea-sized for the whole face. More is not better — excess increases irritation without faster results. |
| Acclimation | Start 2–3 nights per week for 2 weeks, then alternate nights for 2 weeks, then nightly. Buffer with moisturiser if needed (sandwich method). |
| Avoid areas | Eyelids, corners of mouth and nose, lips. Apply at least 5 mm away. |
| Sun protection | Mandatory SPF 30+ broad-spectrum every morning. Tretinoin thins the stratum corneum and increases UV sensitivity. |
| Timeline | Acne: visible improvement 8–12 weeks. Photoageing: 6–12 months. Continued daily use is required for benefit to persist. |
✓ The retinoid purge — During weeks 2–4, acne can transiently worsen as comedones surface and inflame. This “purge” is normal and reflects the drug working — micro-comedones that would have appeared over months are accelerated to the surface. Push through unless lesions are severe or painful. Add a non-comedogenic moisturiser to manage irritation; do not stop unless your dermatologist advises.
Side effects
- Very common (initial weeks): dryness, redness, peeling, mild burning. Usually subside by weeks 4–6 as skin acclimates.
- Common: sun sensitivity, transient acne worsening (purge), perioral dermatitis if applied too close to mouth.
- Less common: contact allergy to tretinoin or vehicle, post-inflammatory hyperpigmentation in dark skin.
- Rare: photoallergic reactions.
Drug interactions
Avoid concurrent benzoyl peroxide on the same skin (can oxidise tretinoin — apply at separate times of day, or use a stable BPO + retinoid formulation). Avoid alpha hydroxy acids, glycolic peels, salicylic acid, and microdermabrasion in the same evening. Pause tretinoin 7 days before any chemical peel or laser. Concurrent vitamin A supplements at high dose increase systemic retinoid load.
Contraindications
- Pregnancy (Category X) — tretinoin is teratogenic; effective contraception is required.
- Breastfeeding (limited data; avoid).
- Eczema, severe sunburn, broken skin at the application site.
- Known sensitivity to retinoids or vehicle.
Storage
Store below 25 °C, away from direct light. Tretinoin oxidises in light and air — keep tube cap firmly closed and out of direct sunlight.
Συχνές Ερωτήσεις
How long before I see results with Tretin Cream?
Acne improvement at 8–12 weeks; photoageing benefits at 6–12 months. Continued nightly use is needed to maintain results.
My skin is peeling after 1 week — is this normal?
Yes. Peeling, mild redness, and dryness are universal in the first 4–6 weeks. Buffer with a non-comedogenic moisturiser, reduce frequency to alternate nights, and use a gentle cleanser. If pain, severe burning, or open skin appear — stop and consult.
Can I use Tretin Cream in pregnancy?
No. Topical tretinoin is FDA Category X — teratogenic risk. Stop before conception and use effective contraception throughout treatment.
Should I use moisturiser with tretinoin?
Yes. A non-comedogenic moisturiser before or after tretinoin reduces irritation without significantly reducing efficacy. The “sandwich method” — moisturiser, tretinoin, moisturiser — is well-established for sensitive skin.
Why does my acne look worse after 2 weeks?
That is the retinoid purge. Comedones that would have surfaced over months are accelerated and inflame. Continue treatment unless severe; the purge resolves by week 4–6.
Can I use Tretin Cream with benzoyl peroxide?
Yes, but apply at separate times — BPO in the morning, tretinoin at night — unless you have a stable combination product. BPO can oxidise tretinoin in the same application.
How is tretinoin different from retinol?
Retinol is a precursor that the skin must convert to tretinoin (retinoic acid) — a process that loses ~90% of activity. Tretinoin is the active form, so it is much faster but more irritating. Retinol is gentler but slower (typically 1 strength of retinol ≈ 1/10 the strength of tretinoin).
Can I use Tretin Cream for wrinkles?
Yes — long-term nightly use over 6–12 months produces measurable improvement in fine lines, uneven pigmentation, and skin texture from UV damage. Tretinoin is the gold-standard topical for photoageing.
What happens if I miss a few nights?
No major issue — resume your usual schedule. Do not double up to “catch up” — that just increases irritation.
Is tretinoin the same as isotretinoin (Accutane)?
No. Tretinoin (Tretin Cream) is topical and has minimal systemic absorption. Isotretinoin is the oral retinoid for severe acne and has very different (and stronger) systemic effects. Both are teratogenic.
Other Beauty & Skin Care Medications
- Melalite Forte Cream — hydroquinone 4% for melasma
- Retino-A Cream — tretinoin for acne and ageing
- Melacare Cream — Kligman triple for melasma
- Permite Cream — permethrin 5% for scabies
- Tenovate Cream — clobetasol 0.05% for severe inflammation
Medical disclaimer. This content is for general information about the product and is not medical advice or a substitute for advice from a qualified healthcare professional. Use any topical or oral medication only under appropriate medical supervision; misuse can cause serious harm.
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| Ισχύς | 0.05% (30gm), 0.1% (20gm) |
|---|---|
| Ποσότητα | 1 Tube/s, 3 Tube/s, 6 Tube/s, 9 Tube/s |
| Pharma Form | Cream/s |
| Manufacturer | Hegde & Hegde |
| Treatment | Acne |
| Generic Brand | Fluocinolone + Hydroquinone + Tretinoin |
Tretin Cream
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