Diligan
✅ Lievittää liikepahoinvointia
✅ Relieves vertigo symptoms
✅ Reduces nausea
✅ Controls dizziness
✅ Treats vomiting
Diligan contains Meclizine.
✓ Lääketieteellinen tarkistus Morgan Ellis — Farmasian tutkija · 8 vuoden kokemus · Viimeisin arvio: toukokuu 2026
⚡ Quick Answer — What is Diligan?
Diligan on meclizine 25 mg tablet from a first-generation H1 antihistamine with anticholinergic and central anti-emetic action. It is taken 1 hour before travel to prevent motion sickness (cars, boats, planes), and short-course (≤ 72 h) to suppress acute peripheral vertigo from labyrinthitis or vestibular neuritis. Typical adult dose is 25–50 mg one hour before travel, repeated every 24 hours if needed. Causes drowsiness — do not drive or operate machinery for 8–12 hours after a dose.
Miksi tilata MedsBasesta
📦 Jokainen tilaus on katettuna meidän Reshipment Assurance Policy -politiikkamme piiriin — jos lähetyksesi ei saavu 20 arkipäivässä, lähetämme uuden.
Diligan is the WHO-GMP generic equivalent of Antivert / Bonine, supplied as 25 mg tablets and chewable tablets. Meclizine has a 60+ year track record for motion sickness and is one of the few drugs with FDA Pregnancy Category B status for nausea/vomiting in pregnancy when other agents are contraindicated.
What Diligan Is Used For
- Motion sickness prevention — first-line for car, sea, and air travel; take 1 hour before exposure
- Acute peripheral vertigo — vestibular neuritis, labyrinthitis, BPPV first attack — short course (≤ 72 hours) only, then stop to allow central compensation
- Acute Meniere’s vertigo episode — rescue dose; chronic management uses betahistine instead
- Post-operative nausea — off-label adjunct after middle-ear surgery
Meclizine is ei the right drug for chronic Meniere’s disease (use Vertin tai Betavert), central vertigo (brain-origin), or general lightheadedness from postural drop or cardiac arrhythmia.
Miksi tilata MedsBasesta
Diligan is dispensed from a WHO-GMP-certified manufacturer, blister-packed and discreetly shipped worldwide. Every order is covered by our Reshipment Assurance Policy -politiikkamme piiriin — jos tuote ei saavu 20 arkipäivässä, toimittamme uuden kustannuksillamme. Yli 1 400 varmennettua asiakasta — lue arvostelut.
How Diligan Works
Meclizine is a piperazine-class first-generation H1 antihistamine that crosses the blood-brain barrier. In the central vestibular pathways it dampens the firing of the vestibular nuclei in response to abnormal sensory input, which is what produces the spinning sensation in motion sickness and acute peripheral vertigo. Its anticholinergic activity also blunts the autonomic component (nausea, sweating, pallor) that accompanies vestibular stimulation.
Onset is 30–60 minuuttia, peak effect at 1–2 hours, duration 8–12 hours. This is why dosing is one hour before travel and repeated daily on long journeys.
Annostus
| Käyttöaihe | Annos | Huomautuksia |
|---|---|---|
| Motion sickness prevention | 25–50 mg, 1 hour before travel | Repeat every 24 h on long trips; max 100 mg/day |
| Acute peripheral vertigo | 25–50 mg twice daily | Maximum 72 hours — longer use delays vestibular compensation |
| Meniere’s acute episode | 25 mg as needed | Add to betahistine maintenance during attack only |
| Children < 12 years | Vältä | Limited paediatric data; use dimenhydrinate or cinnarizine instead |
| Iäkkäät | Start 12.5–25 mg | Higher anticholinergic-burden risk; falls and confusion are real concerns |
| Raskaus | 25 mg as needed | FDA Category B; one of the safer antiemetic options when first-line doxylamine + B6 fails |
Important — Do Not Use Beyond 72 Hours for Vertigo
Haittavaikutukset
| Taajuus | Vaikutus |
|---|---|
| Common (> 10%) | Drowsiness, sedation, dry mouth |
| Common (1–10%) | Blurred vision, constipation, urinary hesitancy, fatigue |
| Epätyypillinen | Tachycardia, palpitations, restlessness in elderly (paradoxical), headache |
| Harvinainen | Acute angle-closure glaucoma, urinary retention, anaphylaxis |
Vastu- ja varoitusmerkinnät
- Closed-angle glaucoma — anticholinergic effect can precipitate acute angle-closure attack
- Prostatic hypertrophy / urinary retention — worsens outflow obstruction
- Severe asthma / COPD — thickens bronchial secretions
- Alle 12-vuotiaat lapset — insufficient data; alternatives exist
- Concurrent sedatives or alcohol — additive CNS depression
- Raskaus ja imetys — FDA Category B; small amounts in breast milk — preferred over scopolamine if needed
Lääkeaineenvaihdunta
| Lääkeaine / Luokka | Vuorovaikutus |
|---|---|
| Alcohol, opioids, benzodiazepines, hypnotics | Additive sedation; avoid combining at full motion-sickness doses |
| Other anticholinergics (oxybutynin, scopolamine, TCAs, first-gen antihistamines) | Cumulative anticholinergic burden — dry mouth, constipation, urinary retention, confusion in elderly |
| MAO-estäjät | Prolong and intensify anticholinergic effects |
| Levodopa | Antihistamine may reduce levodopa effect; rarely clinically important at single doses |
| Cinnarizine, betahistine | Pharmacological antagonism; do not combine routinely — pick one strategy |
Säilytys
- Alle 25 °C:ssa kuivassa paikassa, suorasta auringonvalosta erillään
- Pidä alkuperäisessä blisterissä, lasten ulottumattomissa
- Älä käytä vanhentuneena
Usein Kysytyt Kysymykset
When should I take Diligan before travel?
One hour before exposure to motion. The 25–50 mg dose reaches peak plasma level at 1–2 hours and lasts 8–12 hours, so a single dose covers a full day of travel. For multi-day journeys, repeat once every 24 hours.
Diligan vs Vertin — which one do I need?
Diligan (meclizine) on tarkoitettu acute, short-term vestibular suppression: motion sickness, the first 48–72 hours of a peripheral vertigo episode, or a Meniere’s acute attack. Vertin / Betavert (betahistine) on tarkoitettu chronic maintenance of Meniere’s disease — reducing the frequency of future attacks over weeks to months. They have opposite roles.
Can I take Diligan during pregnancy?
Meclizine has FDA Pregnancy Category B classification — one of the safer antiemetics when first-line doxylamine + pyridoxine fails. Discuss with your obstetrician before regular use.
Does Diligan make you drowsy?
Yes — sedation is the most common side effect, occurring in over 10% of users. Do not drive or operate machinery for 8–12 hours after a dose. Take the first dose at home before travel day to learn your individual reaction.
How is Diligan different from Phenergan / Avomine?
Promethazine (Phenergan, Avomine) is a phenothiazine with stronger sedation and antiemetic effect — preferred when nausea is the dominant symptom, but more sedating and not safe in children under 2 years. Meclizine has a milder sedation profile and longer duration, making it more practical for an adult travel day.
Can children take Diligan?
Meclizine is not recommended for children under 12 years — safety data are limited. For paediatric motion sickness, dimenhydrinate or cinnarizine are typically used instead, under medical guidance.
Will Diligan stop a Meniere’s attack?
It blunts the vertigo and nausea of an active episode but does not change the underlying disease. For chronic Meniere’s management, betahistine (Vertin tai Betavert), salt restriction, and hydration are the maintenance strategy. Meclizine is rescue only.
Is Diligan addictive?
No — meclizine is not a controlled substance and has no dependence potential. The main long-term concern is the anticholinergic burden in elderly users (dry mouth, constipation, cognitive effects).
Does Diligan help BPPV?
Only short-term during the most severe symptoms. BPPV is mechanical — a displaced otolith crystal in a semicircular canal — and the definitive treatment is a canalith-repositioning manoeuvre (Epley, Semont). Meclizine masks symptoms; it does not relocate the crystal. Use it for the first 24–48 hours, then have someone perform the Epley manoeuvre.
Can I drink alcohol on Diligan?
Avoid alcohol while taking meclizine. Combined CNS depression worsens drowsiness, balance, and reaction time — a real fall and accident risk, especially in older adults.
How long does Diligan take to start working?
30–60 minutes to perceptible effect; peak at 1–2 hours; duration 8–12 hours. Take it 1 hour before exposure for prevention — taking it after motion sickness is established is much less effective than preventing it before.
Meclizine in Diligan is a longer-acting, less-sedating option for daytime motion sickness, but when stronger sedation is wanted overnight on a ferry or coach a single Avimax (prometatsiini 25 mg) taken pre-travel delivers heavier antihistamine antiemetic cover with reliable drowsiness.
Other Vertigo & Motion Sickness Treatments
- Vertin (betahistine 8 mg) — chronic Meniere’s disease maintenance
- Betavert (betahistine 8 / 16 mg) — alternative betahistine brand
- Betavert Tab (betahistine 24 mg) — higher-strength once-daily option
- Avomine (promethazine 25 mg) — alternative motion-sickness antihistamine
- Stemetil MD (prochlorperazine 5 mg ODT) — acute vertigo & nausea rescue
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Luokiteltu MedsBase-tilausmäärän mukaan — mitä muut asiakkaat tässä kategoriassa valitsevat.
| Vahvuus | 25 mg |
|---|---|
| Määrä | 30 tablettia, 60 tablettia, 90 tablettia, 180 tablettia |
Diligan
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Diligan
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