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Stemetil

Stemetil (Prochlorperazine 5 mg) — phenothiazine antiemetic and vestibular suppressant for severe nausea, vomiting, vertigo, Meniere’s disease, and migraine-associated vomiting. WHO-GMP certified manufacturer. Worldwide shipping from MedsBase.

⚡ Quick Answer — What is Stemetil?

Stemetil is prochlorperazine maleate 5 mg — a phenothiazine first-generation antipsychotic widely used at low doses for severe nausea and vomiting, vertigo, Meniere’s disease, and the labyrinthine vertigo of inner-ear dysfunction. It blocks central D2 dopamine receptors in the chemoreceptor trigger zone (antiemetic) and in the labyrinth (anti-vertigo), and to a lesser extent histamine H1 and muscarinic receptors. Standard dose: 5–10 mg three times daily orally for nausea or vertigo, max 30 mg/day; bipolar/schizophrenia at higher doses is rarely used today given atypical antipsychotic alternatives. WHO-GMP certified manufacturer.

Miksi tilata MedsBasesta:WHO-GMP sertifioitu valmistaja ✔ Discreet packaging ✔ Worldwide shipping ✔ Verified customer reviews (1,400+ customers)

📦 Jokainen tilaus on katettuna meidän Reshipment Assurance Policy -politiikkamme piiriin — jos lähetyksesi ei saavu 20 arkipäivässä, lähetämme uuden.

Miksi tilata MedsBasesta

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⚠️ FGA antipsychotic warnings. Prochlorperazine is a typical (first-generation) antipsychotic and shares the class warnings of acute dystonia, akathisia, parkinsonism, neuroleptic malignant syndrome, and tardive dyskinesia. Risk is dose-and-duration dependent; the antiemetic doses used for nausea/vertigo are lower than antipsychotic doses but extrapyramidal effects still occur (notably in young men and elderly women). Increased mortality has been observed in elderly dementia patients on antipsychotics — avoid in this population. Avoid in Parkinson’s disease.

Miksi tilata MedsBasesta

Stemetil is supplied from a WHO-GMP sertifioitu valmistaja. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy -politiikkamme piiriin — if it does not arrive within 20 business days, we reship at no cost. Stemetil is a long-established antiemetic and vestibular suppressant used worldwide for severe nausea, vertigo, and Meniere's symptom flares.

Mechanism

Prochlorperazine antagonises central D2 dopamine receptors. In the chemoreceptor trigger zone this produces a strong antiemetic effect (more potent than metoclopramide for severe vomiting). In the inner ear and brainstem vestibular nuclei it suppresses vertigo. H1 antagonism explains the sedation; muscarinic antagonism explains dry mouth. At higher doses it has the typical FGA pharmacology (positive-symptom psychosis suppression).

Indikaatiot

  • Severe nausea and vomiting (chemo, post-op, migraine, gastroenteritis)
  • Vertigo (vestibular neuronitis, BPPV with severe symptoms, Meniere's flare)
  • Meniere’s disease symptom relief (combined with diuretic / dietary salt restriction)
  • Labyrinthitis
  • Schizophrenia (rarely — superseded by atypicals)

Annos

Adults: 5–10 mg three times daily orally for nausea/vertigo. Acute migraine-associated nausea: 5–10 mg single dose. Meniere’s: 5 mg three times daily, titrate to symptom control (max 30 mg/day). Children: avoid < 10 kg. Hepatic impairment: reduce dose. Elderly: start at half-dose — very high EPS risk.

Sivuvaikutukset

  • Common: drowsiness, dry mouth, constipation, blurred vision, postural hypotension
  • Extrapyramidal: acute dystonia (oculogyric crisis, torticollis), akathisia, parkinsonism, tardive dyskinesia
  • Hyperprolactinaemia: galactorrhoea, menstrual changes
  • QT prolongation, torsades de pointes (rare)
  • Photosensitivity skin rash, cholestatic jaundice (idiosyncratic)
  • Neuroleptic malignant syndrome (rare, life-threatening)

Lääkevuorovaikutukset

  • Other dopamine antagonists (metoclopramide, haloperidol, atypicals): additive EPS — avoid stacking.
  • QT-prolonging drugs (azithromycin, fluoroquinolones, ondansetron, citalopram, methadone): avoid combination.
  • CNS depressants (alcohol, opioids, benzodiazepines): additive sedation, hypotension.
  • Levodopa, dopamine agonists: each blocks the other's effect — avoid in Parkinson’s.
  • Anticholinergics: additive dry mouth, urinary retention, constipation.

Usein Kysytyt Kysymykset

What is Stemetil mainly used for?

Severe nausea, vomiting, and vertigo. It is more potent than metoclopramide for severe vomiting and is the standard for vestibular vertigo flares.

How quickly will it work?

Antiemetic effect within 30–60 minutes orally. The IM and rectal routes (5 mg or 25 mg suppositories) act within 30 minutes when the patient cannot keep tablets down.

Is it safe to drive on this?

Drowsiness is common. Do not drive until you know how it affects you. The first 1–2 weeks are usually most sedating.

Can I take it with my migraine medication?

Yes — prochlorperazine is often combined with triptans and analgesics during a migraine attack to control nausea. Avoid with QT-prolonging triptan combinations and tell the prescriber.

Is it the same as metoclopramide?

Both are D2 antagonists. Prochlorperazine is more potent for severe vomiting and is preferred for vertigo. Metoclopramide is more prokinetic. Both share extrapyramidal side-effect risk.

Why am I getting muscle spasms?

Acute dystonia is a recognised early side effect — uncontrolled muscle pulling in the neck, jaw, eyes, or trunk. Stop the drug and seek medical help. Treated with IV anticholinergic (procyclidine).

Can I take it long-term for Meniere’s?

Short-to-medium courses for symptom flares are typical. Long-term use (months) raises tardive dyskinesia risk — specialist ENT/neurology supervision recommended.

Is it safe in pregnancy?

Category C. Sometimes used for severe hyperemesis gravidarum when first-line fails. Discuss with obstetric prescriber.

Säilytys

Below 25°C, away from light. Keep out of reach of children.

Mitä teen, jos unohdan ottaa annoksen?

Take it as soon as you remember. If close to the next dose, skip it. Do not double up.

Other Gastro Health Medications

⚕ Lääketieteellinen vastuuvapauslauseke. This page is for informational purposes only and does not replace medical advice from a qualified healthcare professional. Persistent vertigo or vomiting needs assessment for vestibular, cardiac, and neurological causes.

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