Valclovir

✅ Treats herpes infections
✅ Reduces outbreak severity
✅ Lyhentää parantumisaikaa
✅ Suppresses viral replication
✅ Eases shingles symptoms

Valclovir contains Valacyclovir.

Tuotekoodi: Ei saatavilla Kategoria: Kategorian yleiskatsaus, Sukuelinherpes (HSV), Seksuaaliterveys Avainsana: Valasikloviiri, Valclovir

✓ Lääketieteellinen tarkistus Morgan Ellis — Farmasian tutkija · 8 vuoden kokemus · Viimeisin arvio: toukokuu 2026

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Vahvuus

500 mg
1000 mg

Määrä

30 tablettia
60 tablettia
90 tablettia
180 tablettia

Tyhjennä

💡 Pikaohje

Valclovir on valacyclovir, a prescription antiviral used for genital herpes (HSV-2), cold sores (HSV-1), and shingles (VZV). Daily dosing can reduce outbreak frequency by up to 75% and lowers partner transmission risk. Take with or without food; start within 24 hours of symptom onset for episodic treatment.

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What Is Valclovir?

Valclovir is a branded generic of valacyclovir, the L-valyl ester prodrug of aciclovir. After oral dosing, valacyclovir is rapidly converted to aciclovir, delivering 3–5× higher plasma levels than oral aciclovir at the same dose frequency. This lets most adults dose twice daily instead of five times daily, improving adherence without sacrificing efficacy.

Valacyclovir treats three main conditions: genital herpes (HSV-2), oral herpes / cold sores (HSV-1), and shingles (varicella-zoster virus). It is available in strengths of 500 mg, 1000 mg.

Kliiniset käyttöalueet

Sukuelinherpes (ensimmäinen episodi): 1000 mg twice daily for 10 days
Sukuelinherpes (toistuva episodi): 500 mg twice daily for 3 days — start within 24 hours of prodrome
Sukuelinherpes (ehkäisevä hoito): 500 mg once daily (up to 1000 mg daily for ≥10 outbreaks/year)
Reducing partner transmission: 500 mg once daily — shown to reduce transmission by ~48% in heterosexual serodiscordant couples (Corey et al., 2004)
Huuliherpes (herpes labialis): 2000 mg twice daily for one day (two doses 12 hours apart)
Vyöruusu (herpes zoster): 1000 mg three times daily for 7 days — start within 72 hours of rash onset

Käyttöohje

Swallow the tablet whole with a full glass of water. With or without food — either is fine.
Stay well hydrated. Valacyclovir is cleared renally; dehydration plus high doses can crystallise in tubules (rare but reversible).
For episodic genital or oral herpes, start dosing at the first sign (tingling, itching, burning) — every hour of delay reduces benefit.
For daily suppressive therapy, take at the same time each day; missing doses reduces suppression effectiveness.
Suorita täysi hoitokausi, vaikka oireet helpottaisivat.

Renal Dosing Adjustment

Valacyclovir is almost entirely cleared by the kidneys. Standard doses may require reduction in renal impairment:

Creatinine clearance (mL/min)	Dose adjustment
≥50	No adjustment
30–49	Reduce dose or extend interval (e.g. 1000 mg every 12 h → every 24 h)
10–29	Significant reduction; consult clinician
<10	Specialist dosing required

Haittavaikutukset

Yleiset (≥1%): headache, nausea, abdominal pain, fatigue. Usually mild and self-limiting.

Vähemmän yleisiä: dizziness, rash, photosensitivity.

Vakavat (harvinaiset): thrombotic thrombocytopenic purpura / hemolytic uremic syndrome (TTP/HUS) has been reported at very high doses in severely immunocompromised patients. Acute kidney injury in dehydrated patients at high doses. Neurotoxicity (confusion, hallucinations) rare and usually associated with renal impairment + high dose.

Who Should Not Take Valclovir

Known hypersensitivity to valacyclovir or aciclovir
Severe immunodeficiency without specialist supervision (TTP/HUS risk)
Caution in renal impairment — dose adjustment required
Caution in pregnancy / breastfeeding — discuss with clinician (category B in most jurisdictions; widely used but individual risk-benefit assessment required)

Lääkeaineenvaihdunta

Probenecid + cimetidine: reduce renal clearance of aciclovir — may raise plasma levels. Clinically significant only at high doses.
Mykofenolaattimofetili: may increase valacyclovir plasma concentration.
Muut nefrotoksiset lääkeaineet (aminoglycosides, high-dose NSAIDs, amphotericin B): combined use requires careful hydration and renal monitoring.
Sidovudiini: may increase neurotoxicity risk in combination.

Säilytys

Store at room temperature (15–30 °C / 59–86 °F) away from direct sunlight and moisture. Keep tablets in the original foil blister. Keep out of reach of children. Do not use after the printed expiry date.

Valclovir vs Aciclovir

Valacyclovir is a prodrug of aciclovir with much better bioavailability (~55% vs ~15–20%). Practical implication: twice-daily valacyclovir produces the same antiviral effect as five-times-daily aciclovir, making it far easier to stick with. Most modern herpes guidelines (CDC, BASHH, WHO) list valacyclovir as first-line for outpatient use. Aciclovir remains standard when cost is the primary constraint or for IV administration.

See our detailed comparison: Valacyclovir vs Acyclovir.

Usein Kysytyt Kysymykset

Does Valclovir cure herpes?

No. There is no cure for herpes — the virus remains latent in nerve ganglia for life. Valclovir suppresses viral replication, shortens outbreaks, reduces outbreak frequency, and lowers partner transmission risk, but cannot eliminate the virus from the body.

How quickly does Valclovir work?

For episodic treatment, most patients report symptom improvement within 24–48 hours of starting. Lesions heal ~1–2 days faster than untreated. For suppressive daily dosing, full effect (reduced outbreak frequency) builds over the first month.

Can I drink alcohol while taking Valclovir?

Alcohol does not directly interact with valacyclovir, but dehydration from heavy drinking can stress the kidneys (valacyclovir clears renally). Moderate intake is generally fine; hydrate well.

Can I take Valclovir during pregnancy?

Valacyclovir is Category B in most jurisdictions and is widely used in pregnancy, particularly near term to reduce neonatal herpes risk in women with active genital herpes. Always discuss with your obstetrician.

Will Valclovir protect my partner?

Daily suppressive valacyclovir reduces heterosexual transmission by ~48% (Corey et al., 2004). It is not 100% protective — consistent condom use and avoiding sex during outbreaks remain important.

How long can I stay on suppressive therapy?

Years, safely. Long-term studies show valacyclovir is well tolerated for suppressive use over 5+ years with no cumulative toxicity at standard doses in people with normal kidney function.

Mitä teen, jos unohdan ottaa annoksen?

Take it as soon as you remember, unless it is almost time for the next dose — in that case skip and continue. Do not double-dose.

Can I take Valclovir for shingles?

Yes — 1000 mg three times daily for 7 days, started within 72 hours of rash onset. Earlier treatment reduces pain, speeds healing, and lowers post-herpetic neuralgia risk.

Aiheeseen liittyvät tuotteet ja oppaat

⚕️ Lääketieteellinen vastuuvapauslauseke: Tällä sivulla olevat tiedot ovat vain koulutusmielessä eivätkä korvaa lääketieteellistä neuvontaa. Kysy aina pätevän lääketieteen ammattilaisen neuvoja ennen minkään lääkkeen aloittamista, lopettamista tai muuttamista. Reseptilääkkeitä tulisi käyttää vain lääketieteellisen valvonnan alaisena.

Valclovir (valacyclovir 500 / 1000 mg) ja Centrex (valasikloviri 500 / 1000 mg) are equivalent valacyclovir tablets from different Indian manufacturers — pick on stock and pack size; clinical effect, indications (HSV-1 / HSV-2 / VZV), and dosing schedules are identical.