Cardivas
Cardivas is Sun Pharma’s carvedilol 3.125/6.25/12.5/25 mg tablets — non-cardioselective beta-blocker with additional alpha-1 antagonism, giving vasodilation in addition to rate and contractility reduction. Landmark HF evidence: COPERNICUS (severe HF-REF, 35% mortality reduction), CAPRICORN (post-MI), COMET (carvedilol superior to metoprolol tartrate in HF). Uses: HF with reduced ejection fraction (first-line alongside ACEi/ARNI + MR antagonist), hypertension, post-MI LV dysfunction, chronic stable angina. Dose-titrate every 2 weeks from 3.125 mg BD; target 25 mg BD.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
⚡ Quick Answer — What is Cardivas?
Cardivas είναι 3.125 / 6.25 / 12.5 / 25 mg carvedilol immediate-release tablet from Sun Pharma — non-selective beta-blocker with additional alpha-1 blockade. Primary use is hypertension; also used for angina, arrhythmia control, post-myocardial-infarction secondary prevention, and heart failure with reduced ejection fraction (HF-REF) (one of the three mortality-proven beta-blockers in HF-REF). Typical hypertension dose: 6.25-25 mg twice daily (12.5-50 mg/day). Contraindicated in asthma, severe bradycardia, second/third-degree heart block, acute decompensated heart failure, and phaeochromocytoma without prior alpha-blockade. Do NOT stop abruptly — taper over 1-2 weeks to avoid rebound tachycardia / angina / MI.
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What Is Cardivas?
Cardivas is an oral immediate-release tablet containing carvedilol 3.125 / 6.25 / 12.5 / 25 mg from Sun Pharma, supplied in 30-90 tablets. Carvedilol is a non-selective beta-blocker with additional alpha-1 blockade. Third-generation beta-blocker with vasodilator properties from alpha-1 blockade. Distinguished by landmark heart-failure evidence (COPERNICUS, CAPRICORN): one of only three beta-blockers (with metoprolol succinate and bisoprolol) proven to reduce mortality in HF-REF.
How Carvedilol Lowers Blood Pressure
Beta-blockers reduce blood pressure through four mechanisms:
- Reduction of cardiac output — beta-1 blockade in the sinoatrial node reduces heart rate, and blockade in ventricular myocardium reduces contractility. Lower cardiac output = lower blood pressure.
- Renin-angiotensin suppression — beta-1 blockade in juxtaglomerular cells reduces renin release, lowering angiotensin II and aldosterone over 2-4 weeks. This accounts for much of the long-term BP effect.
- Central sympathetic reduction — lipophilic beta-blockers cross the blood-brain barrier and reduce central sympathetic outflow.
- Alpha-1 blockade — direct peripheral vasodilation (carvedilol-specific), giving a faster BP reduction than pure beta-blockers.
Beta-blockers are lipophilic. Plasma half-life of carvedilol is 7-10 hours.
Approved and Evidence-Based Uses
- Hypertension (primary indication)
- Heart failure with reduced ejection fraction (HF-REF) — evidence-based, mortality-reducing; titrate from 3.125 mg BID to 25 mg BID (50 mg BID in patients >85 kg) over 8-12 weeks
- Post-MI secondary prevention — CAPRICORN trial
- Stable angina
- Left ventricular dysfunction post-MI
Cardivas Dosage
Adult hypertension dose: 6.25-25 mg twice daily (12.5-50 mg/day).
Start low, titrate upward over 2-4 weeks to target BP (typically <140/90 in uncomplicated hypertension; <130/80 in diabetes, chronic kidney disease, or established cardiovascular disease). Check resting pulse before each dose-increase — do not titrate if <55 bpm.
Παρακολούθηση:
- Resting pulse and BP at 2, 4, and 8 weeks after starting or dose change
- Baseline ECG if any cardiac history; periodic ECG if symptoms change
- For HF-REF use: echocardiogram at 3 and 6 months; titrate toward target dose if tolerated
Administration: swallow whole with water. Take at approximately the same time each day.
Discontinuation: NEVER stop abruptly. Taper over 1-2 weeks (reduce by 25-50% every 3-5 days). Abrupt discontinuation causes rebound tachycardia, worsened angina, and — in patients with coronary disease — can precipitate myocardial infarction. This is one of the most important safety points for beta-blockers.
Παρενέργειες
Common (>5%):
- Fatigue, lethargy — often adapts over 2-4 weeks
- Cold hands and feet (peripheral vasoconstriction)
- Bradycardia (check pulse; stop if <50 bpm)
- Exercise intolerance — maximum heart rate is blunted by beta blockade
- Dizziness, postural hypotension
- CNS effects possible but less common than with propranolol
- Postural dizziness (more common due to vasodilator component)
Λιγότερο συχνές: depression, reduced libido / erectile dysfunction, gastrointestinal upset, Raynaud-like cold intolerance, bronchospasm (more common with non-selective agents).
Important but uncommon:
- Masked hypoglycaemia in diabetics — beta-blockers blunt the tachycardia / tremor warning signs of low blood sugar. Monitor glucose more carefully; prefer nebivolol ή bisoprolol in insulin-treated diabetes.
- Bronchospasm — can be severe in asthma / COPD. Absolute contraindication for non-selective agents; relative for cardioselective.
- Heart block or worsening heart failure — in susceptible patients. Start low, titrate slowly.
Contraindications & Cautions
- Asthma / severe COPD / any bronchospastic disorder — absolute contraindication (non-selective beta blockade)
- Second or third-degree atrioventricular block (without pacemaker)
- Sinus bradycardia <50 bpm
- Cardiogenic shock, decompensated heart failure requiring inotropes
- Severe peripheral arterial disease, Raynaud’s syndrome (relative)
- Phaeochromocytoma without prior alpha-blockade — paradoxical hypertensive crisis (Carvedilol has alpha-1 blocker component, which softens but does not eliminate this risk)
- Severe hepatic impairment (for extensively hepatic-metabolised agents: propranolol, metoprolol, carvedilol, labetalol)
- Severe renal impairment — dose adjustment needed for renal-excreted agents (atenolol, nadolol)
- Hypersensitivity to carvedilol
Pregnancy: Category C; cross the placenta; small risk of intrauterine growth restriction, neonatal bradycardia, and hypoglycaemia. Use only if benefit clearly outweighs risk; labetalol is the pregnancy-preferred beta-blocker.
Breastfeeding: small amounts in breast milk; generally considered compatible with monitoring.
Αλληλεπιδράσεις Φαρμάκων
- Verapamil, diltiazem (non-dihydropyridine CCBs) — additive bradycardia, heart block, and negative inotropy; generally avoid combination. Dihydropyridine CCBs (amlodipine, nifedipine) are safer to combine with beta-blockers.
- Other beta-blockers — do not combine; additive bradycardia
- Clonidine — if stopping clonidine, stop the beta-blocker first (several days before) to avoid rebound hypertensive crisis
- Insulin and sulphonylureas — mask hypoglycaemia warning signs; monitor glucose closely
- Μη στεροειδή αντιφλεγμονώδη φάρμακα (NSAIDs) — reduce the antihypertensive effect of beta-blockers; avoid chronic combination
- CYP2D6 inhibitors (fluoxetine, paroxetine, quinidine, bupropion) — raise carvedilol levels; reduce dose or monitor closely
- Αλκοόλ — additive hypotension and CNS depression (particularly for lipophilic agents)
Beta-Blocker Class at a Glance
| Beta-blocker | Selectivity | Καλύτερο για |
|---|---|---|
| Propranolol (Inderal, Ciplar, Beloc) | Non-selective | Migraine, tremor, thyrotoxicosis, performance anxiety, HTN |
| Metoprolol | Cardioselective | Post-MI, HF-REF (succinate ER), angina, AF rate control |
| Carvedilol | Non-selective + α-1 | HF-REF (mortality evidence), post-MI |
| Bisoprolol | Highly cardioselective | HF-REF, HTN, angina, AF rate control |
| Nebivolol | Ultra-selective + NO | Elderly, metabolic syndrome, erectile dysfunction |
| Atenolol | Cardioselective (hydrophilic) | Angina, AF rate control (second-line for HTN) |
| Labetalol | Non-selective + α-1 | Pregnancy hypertension, hypertensive crisis |
Το 3.125 mg starter strength (Carloc) and 6.25 mg step-up (Carvego) are designed for the gradual HF-REF titration ladder. Non-selective; contraindicated in asthma.
Αποθήκευση
Store Cardivas below 25°C. Keep out of reach of children — accidental paediatric beta-blocker ingestion can cause life-threatening bradycardia and hypoglycaemia.
Συχνές Ερωτήσεις
How long does Cardivas take to lower blood pressure?
You should see some BP reduction within 1-2 days of starting; the full antihypertensive effect takes 2-4 weeks (driven by the gradual renin-angiotensin suppression, not the immediate heart-rate effect). Measure BP at home at the same time each day to track response.
Can I take Cardivas if I have asthma?
No — Carvedilol is non-selective and can cause severe bronchospasm in asthmatics. Absolute contraindication. For asthmatic patients needing a beta-blocker, nebivolol ή bisoprolol (highly cardioselective) are safer alternatives — though no beta-blocker is completely safe in asthma.
Why should I never stop Cardivas abruptly?
Abrupt discontinuation causes rebound tachycardia and worsened angina within 24-48 hours, driven by up-regulation of beta receptors during chronic blockade. In patients with coronary artery disease, this can precipitate myocardial infarction or unstable angina. Always taper over 1-2 weeks when stopping.
Will Cardivas affect my exercise performance?
Yes — beta blockade blunts the heart-rate response to exercise, so your maximum pulse is lower and you fatigue faster at high intensities. For recreational exercise most people adapt; for competitive endurance athletes, beta-blockers can meaningfully impair performance and are banned in precision sports (shooting, archery — where they reduce physiological tremor).
Will Cardivas affect my blood sugar if I have diabetes?
Βήτα-αναστολείς mask the tachycardia / tremor / palpitation warning signs of hypoglycaemia, making low blood sugar harder to detect. They can also blunt the counter-regulatory glucose response. Monitor glucose more frequently on a beta-blocker, particularly if on insulin or sulphonylureas. Nebivolol και bisoprolol have the best metabolic profile.
Can I drink alcohol on Cardivas?
Moderate alcohol is generally acceptable but alcohol potentiates the hypotensive and CNS-depressant effects. Stand up slowly after drinking. Alcohol is also an independent BP-raiser; reducing intake can improve BP control independent of Cardivas.
Does Cardivas cause weight gain?
Older beta-blockers (propranolol, atenolol, metoprolol) are associated with modest weight gain (1-3 kg) and worsening of insulin sensitivity over time. Nebivolol and carvedilol are weight-neutral or slightly weight-favourable due to their vasodilator components. For patients with metabolic syndrome, nebivolol is the preferred beta-blocker when one is needed.
Is Cardivas safe in pregnancy?
Category C. Use only if benefit clearly outweighs risk. For antihypertensive use in pregnancy, labetalol is the preferred beta-blocker; methyldopa and nifedipine are the two other pregnancy-safe options.
Can I take Cardivas with other BP medications?
Yes — beta-blockers combine well with dihydropyridine calcium-channel blockers (amlodipine), Αναστολείς ACE (ramipril, lisinopril), ARBs (losartan, telmisartan, olmesartan), and thiazide diuretics (HCTZ). Avoid combination with non-dihydropyridine CCBs (verapamil, diltiazem) — additive bradycardia and heart-block risk.
Where can I buy Cardivas online?
You can buy Cardivas (carvedilol 3.125 / 6.25 / 12.5 / 25 mg immediate-release tablet, 30-90 tablets) from MedsBase with discreet packaging and worldwide shipping.
Related Beta-Blockers & Antihypertensives
- Carloc — Carvedilol 3.125 mg (HF starter)
- Carvego — Carvedilol 6.25 mg
- Metomac — Metoprolol 25 mg
- P-Nolol — Propranolol 20/40 mg
- P-Nolol SR — Propranolol 80 mg sustained-release
- Topme XL — Metoprolol ER 100 mg
- Browse all High Blood Pressure Medications
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| Ισχύς | 3.125 Mg, 6.25 Mg, 12.5 mg, 25 mg |
|---|---|
| Ποσότητα | 30 Δισκία, 60 Δισκία, 90 Δισκία |
| Φαρμακευτική Μορφή | Δισκία |
| Κατασκευαστής | Sun Pharma |
| Θεραπεία | High blood pressure, Heart failure, Chest pain (Angina) |
| Γενόσημη μάρκα | Carvedilol |
Cardivas
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