Perlice Cream
✅ Effective against lice
✅ Kills eggs too
✅ Easy application
✅ Minimal side effects
✅ Fast relief
Perlice Cream contains Permethrin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Perlice Cream?
Perlice Cream is permethrin 1% lotion (120 ml bottle) for head lice. Apply to clean, towel-dried hair, leave on for 10 minutes, then rinse out. Repeat after 7 days to kill newly hatched lice. Wet-comb with a fine-toothed nit comb to confirm clearance. Safe in children from 2 months and during pregnancy / breastfeeding. The 5% formulation (Permiforce Cream) is the right choice for scabies, not this 1% lotion.
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What is Perlice Cream?
Perlice Cream is a permethrin 1% w/v hair lotion (‘cream rinse’) for the treatment of head lice (Pediculus humanus capitis) and their eggs. Despite the name, the formulation is a liquid lotion designed to be massaged into wet hair, not a thick cream. Each 120 ml bottle is sufficient for one or two applications on most heads. Permethrin 1% is a WHO Model Essential Medicine and the most-used pediculicide globally with decades of safety data in children.
How does it work?
Permethrin holds open the voltage-gated sodium channels in lice nerves, paralysing and killing the parasite. It has some residual ovicidal effect (kills eggs) but eggs that have just been laid may survive — that is why a second application 7 days later is essential. Mammalian skin recovers from permethrin binding within minutes, which gives the very wide safety margin.
Indications
- Head lice (Pediculus humanus capitis) — first-line topical treatment in adults and children ≥ 2 months
- Pubic lice (Pthirus pubis) — applied to affected areas (often the 5% formulation is used instead)
- Body lice — usually adjunct to clothing / bedding hygiene
For scabies, use the 5% cream formulation — see Permiforce Cream.
How to apply Perlice Cream
| Step | What to do |
|---|---|
| 1. Wash hair | Wash with a non-conditioning shampoo (conditioner can coat hair shafts and reduce permethrin contact). Towel-dry until just damp — not dripping. |
| 2. Apply lotion | Pour enough lotion to thoroughly saturate scalp and hair from roots to tips. Massage in. Cover behind ears and at the nape of the neck — favourite louse hideouts. |
| 3. Leave 10 minutes | Set a timer. Longer is not better — 10 minutes is the validated contact period. |
| 4. Rinse | Rinse out thoroughly with warm water; do not shampoo again for 24 hours. |
| 5. Wet-comb | While hair is still wet, comb section by section with a fine-toothed lice comb to remove dead lice and nits. Wipe the comb on a tissue between passes. |
| 6. Repeat at day 7 | A second application 7 days later kills newly hatched lice before they can lay another generation. |
Side effects
- Mild scalp itching, redness, or tingling
- Transient burning sensation at the start of contact (especially on broken skin from scratching)
- Rare: contact dermatitis; numbness; rash
Do not apply to broken or seriously inflamed scalp skin without medical advice. If lice persist after two correctly performed treatments and wet-combing, suspect permethrin resistance (now common in some regions) and switch to ivermectin lotion (Ivrea Shampoo) or oral ivermectin (Iverjohn).
Pregnancy, breastfeeding, and children
- Pregnancy: permethrin 1% is regarded as safe in any trimester.
- Breastfeeding: compatible. Avoid contact with infant skin during application.
- Children ≥ 2 months: safe and standard first-line therapy.
- Infants < 2 months: seek specialist guidance — wet-combing alone is often used.
Drug interactions and contraindications
No clinically significant systemic drug interactions because absorption from intact scalp is negligible. Contraindicated in known permethrin or pyrethroid allergy and in chrysanthemum allergy (potential cross-reactivity). Avoid in active scalp dermatitis, broken skin, or eczematous flares until the barrier improves.
Storage
Store below 25 °C; keep tightly capped; out of reach of children. Avoid contact with eyes, mouth, and mucous membranes during application.
Frequently Asked Questions
How quickly does Perlice Cream kill lice?
Active lice are killed within minutes of contact. Eggs (nits) need a second application at day 7 because permethrin’s ovicidal effect is incomplete.
Why do I have to wet-comb after treatment?
Even a successful course leaves dead lice and nits attached to the hair shaft. Wet-combing every 2–3 days for two weeks removes them, lets you confirm cure, and catches any newly hatched live lice before they can spread.
My child still has lice after two treatments — what now?
Two correctly performed treatments plus wet-combing should clear typical lice. Persistent lice usually means: incomplete contact (conditioner present, hair too dry), missed re-infection from contacts, or genuine permethrin resistance. Switch to topical ivermectin (Ivrea Shampoo) or oral ivermectin (Iverjohn) and check household members.
Can I use Perlice Cream prophylactically?
No. Treat only confirmed infestation — using pediculicides on lice-free children encourages resistance and offers no benefit. Wet-comb regularly during a school outbreak instead.
Do I need to treat the whole family?
Treat anyone with confirmed live lice (found on wet-combing). Don’t pre-emptively treat household members who are clear — wet-comb them weekly during the outbreak to catch any infestation early.
What about sheets, pillows and hats?
Lice can survive away from the scalp for ~24–48 hours. Wash bedding, hats, brushes, and items in close contact with the head in hot water or seal them in a plastic bag for 3 days. Vacuum upholstery; insecticidal sprays for furniture are not needed.
Is permethrin lotion safe in pregnancy?
Yes, the WHO and most national guidelines list permethrin as a preferred pediculicide in any trimester.
Can I shampoo my hair the day after treatment?
Avoid shampooing for the first 24 hours after the lotion is rinsed out — the residual permethrin on the hair contributes to the kill of any lice missed at first contact.
Why is the bottle called ‘Cream’?
Brand naming convention. The formulation is a liquid lotion / cream rinse — not a thick cream. The thicker 5% scabies cream is Permiforce Cream.
Does Perlice Cream kill nits (eggs)?
Partially. The 7-day repeat is essential because eggs that survive the first application hatch in 7–10 days; the second treatment kills the new generation before they mature.
Other Lice & Scabies Treatments
Patients in whom a single Perlice Cream (permethrin 1%) application proves insufficient — a limitation well-documented in resistance-prevalent regions — may achieve complete eradication with Ivrea Shampoo (ivermectin 1% shampoo), which acts via glutamate-gated chloride channels that entirely bypass the pyrethroid resistance pathway.
- Permiforce Cream — permethrin 5% cream for scabies
- Ivrea Shampoo — topical ivermectin 1% — alternative for resistant head lice
- Iverjohn — oral ivermectin 3 / 6 / 12 mg — for severe or treatment-failed head lice
- Verpin — ivermectin 6 mg tablets
- Ivrea Cream — topical ivermectin 1% — off-label option for small-area lice
Medical Disclaimer
This page is for educational purposes and is not a substitute for medical advice. Resistant or atypical infestations, persistent itch despite proper application, infested children < 2 years old, immunocompromised patients (crusted/Norwegian scabies risk), and pregnancy / breastfeeding cases need clinical assessment. Severe widespread skin infection, fever, or systemic symptoms after a course of treatment require urgent medical review. Always discuss treatment in pregnancy or breastfeeding with a clinician.
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| Quantity | 1 Bottle/s, 2 Bottle/s, 3 Bottle/s, 6 Bottle/s |
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