Seroflo Multihaler
✅ Long-term asthma control
✅ Reduces airway inflammation
✅ Relieves bronchospasm
✅ Improves lung function
✅ Prevents asthma symptoms
Seroflo Multihaler contains Salmeterol and Fluticasone Propionate.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
⚡ Quick Answer — What is Seroflo Multihaler?
Seroflo Multihaler είναι combination preventer (controller) inhaler for asthma and COPD, containing fluticasone propionate (an inhaled corticosteroid that reduces airway inflammation) plus σαλμετερόλη (a long-acting β2 agonist that holds the airways open for 12 hours). Each dose delivers fluticasone 100/250 mcg + salmeterol 50 mcg per dose, κατασκευασμένη από Cipla at WHO-GMP certified facilities — the same active drugs as international brand Seretide Multidose. Seroflo Multihaler is taken twice daily, every day, even when symptoms are absent. It is a preventer, not a rescue inhaler — keep a SABA reliever (Asthalin, Levolin) for acute attacks. Rinse mouth and gargle after every dose to prevent oral thrush and hoarseness.
📦 Κάθε παραγγελία καλύπτεται από την Πολιτική Εγγύησης Επαναποστολής — εάν το δέμα σας δεν φτάσει εντός 20 εργάσιμων ημερών, το επαναποστέλλουμε.
Γιατί να παραγγείλετε από τη MedsBase
Τα γενόσημα φάρμακά μας προέρχονται από κατασκευαστές που πιστοποιούνται από την WHO-GMP και αποστέλλονται παγκοσμίως σε διακριτική, απλή συσκευασία — χωρίς όνομα φαρμάκου στο εξωτερικό του δέματος. Οι πληρωμές με κάρτα δρομολογούνται μέσω ρυθμισμένου επεξεργαστή (οι περιγραφές εκκαθάρισης περιλαμβάνουν ρυθμισμένο επεξεργαστή πληρωμών με κάρτα — ποτέ “MedsBase” ή οποιοδήποτε όνομα φαρμάκου). Γίνονται δεκτές και πληρωμές με κρυπτονομίσματα και τραπεζική μεταφορά SEPA. Κάθε παραγγελία καλύπτεται από την Πολιτική Επαναποστολής Εξασφαλίσεώς μας.
What Is Seroflo Multihaler?
Seroflo Multihaler is an Indian-manufactured dry-powder multihaler που συνδυάζει fluticasone propionate + σαλμετερόλη. The international brand of this combination is Seretide Multidose. Combination ICS-LABA inhalers deliver superior asthma and COPD control compared to either component alone, with a single device improving adherence and reducing the risk of using LABA monotherapy (which carries a black-box warning for asthma death without concomitant ICS).
How Does Seroflo Multihaler Work?
The two active ingredients work on different mechanisms in parallel:
- fluticasone propionate (inhaled corticosteroid): suppresses inflammatory cytokines, reduces eosinophil and lymphocyte infiltration, stabilises airway mucosa, restores β2 receptor responsiveness. Effect builds over 1–2 weeks of consistent dosing.
- σαλμετερόλη (long-acting β2 agonist): activates bronchial smooth muscle β2 receptors, raising cyclic AMP and producing sustained bronchodilation lasting 12 hours (formoterol has 1–3 minute onset; salmeterol 15–30 minute onset).
- Synergy: the corticosteroid restores β2 receptor expression and prevents tachyphylaxis to LABA; the LABA improves smooth-muscle relaxation that ICS alone does not address. Combined, they reduce exacerbations more than either component alone at equivalent doses.
Χρήσεις και ενδείξεις
- Persistent asthma not controlled by ICS alone — first-line ICS-LABA combination
- Asthma maintenance therapy — twice daily, every day, regardless of symptoms
- COPD with frequent exacerbations, especially with elevated blood eosinophil count (≥300/µL) or asthma overlap
- Asthma-COPD overlap syndrome (ACOS)
- Step-up from ICS monotherapy when symptoms or exacerbations persist
Seroflo Multihaler Dosage
| Patient | Δόση | Συχνότητα |
|---|---|---|
| Adults — moderate | 1 inhalation 100/50 | Twice daily |
| Adults — severe | 1 inhalation 250/50 | Twice daily |
| Adults — COPD | 1 inhalation 250/50 | Twice daily |
How to Use Seroflo Multihaler Properly
- Hold the Multihaler upright. Slide the cover down to load a dose.
- Listen for the click — confirms dose readiness.
- Breathe out fully away from the device.
- Seal lips around the mouthpiece.
- Inhale forcefully and deeply.
- Remove, hold breath 10 seconds, breathe out gently.
- Slide the cover up to close.
- Rinse mouth and spit; check the dose counter.
Side Effects of Seroflo Multihaler
Common (mostly local from ICS, plus some β2 effects from LABA):
- Oral thrush (white candidal plaques in mouth or throat)
- Hoarse voice / dysphonia
- Mild tremor (LABA effect; less than with high-dose SABA)
- Palpitations or heart rate increase (≤10 bpm at standard dose)
- Κεφαλαλγία
- Throat irritation, mild cough on inhalation
Λιγότερο συχνές:
- Mild reduction in growth velocity in children at high doses
- Easy bruising at high cumulative ICS doses
- Hypokalaemia at high LABA doses (with diuretics, theophylline, oral steroids)
- Pneumonia in COPD users (slight ICS-related increase)
- Adrenal suppression with high doses or strong CYP3A4 inhibitor co-prescription
Serious (stop and seek emergency help):
- Severe allergic reaction / anaphylaxis
- Paradoxical bronchospasm
- Severe palpitations, chest pain, irregular heartbeat
- Adrenal crisis during illness or surgery
Προειδοποιήσεις και προφυλάξεις
- Use every day, even when you feel well. The benefit accumulates over 1–2 weeks; symptoms return within days of stopping.
- Never use the LABA component alone in asthma — LABA without ICS carries a higher risk of severe asthma death. {$brand} contains both components, so this is not an issue with this product.
- {$brand} is not a rescue inhaler (use Asthalin or Levolin for acute attacks).
- Rinse mouth, gargle, and spit out after every dose; brush teeth before bed.
- COPD users: ICS slightly raises pneumonia risk — ensure ICS adds value (eosinophilic phenotype, frequent exacerbations).
- Ισχυροί αναστολείς CYP3A4 (ritonavir, ketoconazole, itraconazole, clarithromycin) raise systemic exposure of both components — avoid prolonged co-prescription.
- Εγκυμοσύνη και θηλασμός: Budesonide-formoterol has the most pregnancy data; uncontrolled asthma is far more dangerous than the medication.
- Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, severe heart failure.
Αντενδείξεις
- Known hypersensitivity to fluticasone propionate, salmeterol, or any formulation excipient
- Untreated active fungal, bacterial, mycobacterial (TB), or viral respiratory infection
- Severe hypersensitivity to lactose or milk proteins (DPI formulations contain lactose)
- Acute asthma attack — use a SABA reliever instead
Αλληλεπιδράσεις Φαρμάκων
| Interacting drug | Αποτέλεσμα | Τι να κάνετε |
|---|---|---|
| Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin) | Raise systemic ICS exposure → adrenal suppression / Cushing risk | Avoid; monitor cortisol if essential |
| Non-selective beta-blockers (propranolol, timolol drops) | Block LABA effect — risk of severe bronchospasm | Avoid; switch to cardioselective if essential |
| Loop or thiazide diuretics | Additive hypokalaemia from LABA | Monitor potassium with high doses |
| Theophylline / aminophylline | Additive tachycardia and hypokalaemia | Monitor heart rate and potassium |
| MAOIs and tricyclic antidepressants | Potentiate LABA cardiovascular effects | Caution — monitor BP/HR |
Αποθήκευση
- Store below 25°C in a dry place. Keep desiccant in the bottle.
- Do not store in the bathroom — humidity makes the powder clump and reduces dose delivery.
- Once the strip/blister is opened, use within the period stated on the leaflet (typically 2–3 months).
- Keep out of reach of children.
Σχετικές Εναλλακτικές Λύσεις στο MedsBase
- Budecort Inhaler — budesonide ICS preventer
- Asthalin Inhaler — salbutamol reliever
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA add-on
- Duolin Inhaler — salbutamol + ipratropium combo reliever
Συχνές Ερωτήσεις
Is Seroflo the same as Seretide or Advair?
Yes — all three contain fluticasone propionate + salmeterol. Seretide (GSK, EU/UK), Advair (GSK, US), Seroflo (Cipla, India). Clinically interchangeable at equivalent strength pairs.
Why is Seroflo a preventer and not a rescue inhaler?
The salmeterol component has slow onset (15–30 minutes) — it does not relieve acute breathlessness. For acute attacks, use a separate SABA reliever (Asthalin, Levolin). Take Seroflo every day to prevent attacks.
How long until Seroflo starts to work?
Some lung function gain by day 1; symptom improvement by week 1; full preventer effect by 2–4 weeks of consistent twice-daily use.
Why must I rinse my mouth after Seroflo?
Local steroid deposition can cause oral thrush and hoarseness. Rinsing, gargling, and spitting after every dose largely prevents both.
Can children use Seroflo?
Yes from age 4 — typically at 50/25 or 100/25 strength via inhaler with spacer + mask. Higher strengths reserved for older children and adults.
Is Seroflo safe in pregnancy?
Fluticasone has reassuring observational data in pregnancy. Budesonide-formoterol (Foracort) has more data; some prescribers prefer that combination during pregnancy. Uncontrolled asthma is more dangerous than either drug.
Can I use Seroflo as a SMART/MART reliever?
No — salmeterol has slow onset and is not licensed for as-needed use. Only formoterol-containing combinations (Foracort, Symbicort) can be used as SMART/MART.
How long does a Seroflo Inhaler last?
A 120-actuation canister lasts 60 days at twice-daily dosing. Rotacaps come in blister packs; check the leaflet for actuations per pack.
What’s the difference between Seroflo Inhaler, Rotacaps, Multihaler, Autohaler, Accuhaler?
All deliver fluticasone + salmeterol but use different devices and dose strengths. Inhaler = pressurised aerosol with spacer-friendly dosing. Rotacaps = single-dose dry powder via Rotahaler. Multihaler = multi-dose dry powder. Autohaler = breath-activated MDI (no need to coordinate). Accuhaler = multi-dose blister-strip dry powder. Choose based on your inspiratory ability and coordination.
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| Ποσότητα | 1 Inhaler/s, 2 Inhaler/s, 3 Inhaler/s, 6 Inhaler/s |
Seroflo Multihaler
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