Atlura
Atlura (Lurasidone 20/40/80 mg) — 5-HT7-active atypical for schizophrenia and bipolar depression. must be taken with food (≥350 kcal) or absorption halves.
✓ Lääketieteellinen tarkistus Morgan Ellis — Farmasian tutkija · 8 vuoden kokemus · Viimeisin arvio: toukokuu 2026
⚡ Pikaohje
Atlura (Lurasidone 20 / 40 / 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. Must be taken with food (≥ 350 kcal) — fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.
📦 Jokainen tilaus on katettuna meidän Reshipment Assurance Policy -politiikkamme piiriin — jos lähetyksesi ei saavu 20 arkipäivässä, lähetämme uuden.
Miksi tilata MedsBasesta
Atlura at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy -politiikkamme piiriin — 20 arkipäivän toimitusaika tai toimitus uudelleen ilman lisäkustannuksia — ja oikeuttaa asiakasuskollisuusohjelmaan. Maailmanlaajuinen toimitus saatavilla useimpiin kohteisiin.
What Atlura is and how it works
Atlura is a lurasidone tablet supplied by Healing Pharma. Available strengths: 20 / 40 / 80 mg. Lurasidone is a D2/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers — minimal weight gain, minimal lipid effect, minimal glucose effect.
Fasting bioavailability of lurasidone is approximately half the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to “fail” therapy. Take with the largest meal of the day, every day, at the same time. A glass of milk or a small biscuit is not enough — aim for at least 350 kcal of mixed-macronutrient food.
Käyttöaiheet ja annostelu
| Käyttöaihe | Aloitusannos | Tavoiteannos | Enimmäisannos |
|---|---|---|---|
| Skitsofrenia (aikuiset) | 40 mg OD with food | 40–80 mg OD | 160 mg |
| Skitsofrenia (nuoret ≥ 13 v) | 40 mg OD with food | 40–80 mg OD | 80 mg |
| Bipolar depression (adult, monotherapy or adjunct) | 20 mg OD with food | 20–60 mg OD | 120 mg |
| Bipolar depression (paediatric ≥ 10 y) | 20 mg OD with food | 20–80 mg OD | 80 mg |
| Munuaisten vajaatoiminta (CrCl < 50) | 20 mg OD with food | up to 80 mg | 80 mg |
Tärkeät turvallisuushuomiot
Kaikissa epätyypillisissä antipsykooteissa on FDA:n musta laatikko -varoitus kohonneesta kuolleisuudesta (enimmäkseen sydän- ja verisuonitapahtumat ja infektiot), kun niitä käytetään dementiaa sairastavien vanhusten käyttäytymishäiriöiden hoitoon. Epätyypillisiä antipsykootteja ei ole hyväksytty dementiaan liittyvän psykoottisen häiriön tai levottomuuden hoitoon.. Käyttö tässä potilasryhmässä on luvaton, viimeinen keino, ajallisesti rajoitettu ja edellyttää selkeää riski-hyöty-keskustelua.
Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.
Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) — they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) — they reduce levels into the ineffective range.
All antidepressant-class indications carry the under-25 suicidality warning.
Yleiset haittavaikutukset
- Somnolence and sedation — common; usually settles.
- Akatisia — annosriippuvainen.
- Pahoinvointi — first 1–2 weeks; mitigated by food (which is mandatory anyway).
- EPS — uncommon but possible.
- Painonnousu — modest, generally less than olanzapine/quetiapine.
- Prolaktiini — small dose-dependent rise.
- Erottuvat negatiiviset puolet: minimal effect on lipids, glucose, QT.
Lääkevuorovaikutukset
- Voimakkaat CYP3A4-estäjät — contraindicated.
- Voimakkaat CYP3A4-induktorit — contraindicated.
- Moderate CYP3A4 inhibitors (diltiazem, verapamil, fluconazole, erythromycin) — halve lurasidone dose; max 40 mg.
- Muut keskushermostoa lamaavat aineet — additiivinen sedaatio.
- Other antipsychotics — additive EPS, prolactin, NMS risk.
Raskaus, imetys, lasten käyttö
Pregnancy: limited data; weigh against untreated illness. Breastfeeding: insufficient data; generally avoided. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar depression).
Säilytys
Säilytä alkuperäispakkauksessa 15–30 °C lämpötilassa.
Usein Kysytyt Kysymykset
Why does Atlura need to be taken with food?
Fasting absorption is approximately half of fed absorption. The food requirement is not optional — patients who take Atlura on an empty stomach often appear to fail therapy when in fact they are simply under-dosed. The minimum threshold for adequate absorption is approximately 350 kcal of mixed food (a normal meal, not a snack).
Why is Atlura preferred for bipolar depression?
Lurasidone has FDA approval for bipolar depression as monotherapy or adjunct (PREVAIL-2 trial) — one of only three atypicals with this indication (others are quetiapine and olanzapine-fluoxetine). The 5-HT7 antagonism is thought to underlie the antidepressant effect. Lurasidone is a metabolically cleaner choice than quetiapine or olanzapine for bipolar depression.
Will Atlura make me gain weight?
Less than olanzapine, clozapine, quetiapine, or risperidone — typically 1–2 kg over 6 months in monotherapy. One of the better metabolic profiles among atypicals.
How long until Atlura works?
Schizophrenia: positive symptoms typically improve over 2–4 weeks; full effect at 4–6 weeks. Bipolar depression: 2–6 weeks for full effect. Compliance with the food requirement matters — if response is poor, check that doses are being taken with adequate meals.
Can Atlura be combined with mood stabilisers?
Yes — lurasidone is FDA-approved as an adjunct to lithium or valproate in bipolar depression. Combination is common and well-tolerated.
What about driving on Atlura?
Sedation is dose-dependent. Most patients on stable doses drive normally; the first 1–2 weeks of titration can impair reaction time.
How is Atlura different from olanzapine?
Lurasidone has a substantially better metabolic profile (less weight gain, less glucose disturbance, less lipid disturbance) but a slightly higher rate of akathisia and somnolence. Olanzapine is more sedating and has stronger acute antipsychotic effect; lurasidone is preferred for long-term metabolic safety.
Can Atlura be stopped abruptly?
Generally taper over 1–2 weeks, although withdrawal is mild. The relapse risk in schizophrenia and bipolar disease is the main reason for caution — never stop without prescriber agreement.
Why is grapefruit juice a problem?
Grapefruit juice is a strong CYP3A4 inhibitor. Lurasidone is a CYP3A4 substrate; grapefruit raises levels several-fold, increasing sedation, akathisia, and EPS risk. Avoid grapefruit and grapefruit juice during Atlura therapy.
Does Atlura prolong the QT interval?
Less than ziprasidone, less than thioridazine. Lurasidone has a small QT signal but is generally regarded as one of the cleaner atypicals for QT. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.
Muut mielenterveyslääkkeet
- Aripicon (Aripipratsoli — D2-osittainen agonist)
- Olanzap (Olantsapiini — vankka antipsykoottinen)
- Risdone (Risperidone)
- Seroquit (Quetiapine — kaksisuuntainen mielialahäiriö)
- Atlura (Lurasidone — metabolisesti neutraali)
Lisää vaihtoehtoja mielenterveys- ja psykiatrisissa lääkkeissä
Luokiteltu MedsBase-tilausmäärän mukaan — mitä muut asiakkaat tässä kategoriassa valitsevat.
| Vahvuus | 40 mg |
|---|---|
| Määrä | 30 tablettia, 60 tablettia, 90 tablettia, 180 tablettia |
Atlura
Kysymykset ja vastaukset
Atlura
Liittyvät tuotteet
Arvostelut
Ei vielä arvosteluja