HUCOG 10000IU Injection
✅ Supports fertility
✅ Stimulates ovulation
✅ Increases sperm count
✅ Enhances testosterone production
✅ Aids in weight loss
HUCOG 10000IU Injection contains Human chorionic gonadotropin.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer
HUCOG 10000IU Injection — HUCOG 10000 IU Injection is a human chorionic gonadotropin (hCG) preparation used in fertility treatment for women (ovulation trigger and luteal support) and in selected hypogonadism / cryptorchidism protocols in men. Hospital or specialist administration recommended.
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What Is HUCOG 10000IU?
HUCOG 10000IU is a highly purified Human Chorionic Gonadotropin (HCG) injection manufactured by Bharat Serums & Vaccines Ltd., one of India’s largest and most established biopharmaceutical companies with over six decades of experience in serum-based biologics. Each vial contains 10,000 International Units of urinary-derived HCG in lyophilized (freeze-dried) powder form, supplied with a sterile solvent ampoule for reconstitution.
HCG is a glycoprotein hormone naturally produced during pregnancy. Its molecular structure closely resembles luteinizing hormone (LH), which allows it to bind to LH receptors and stimulate the same downstream effects — ovulation in women and testosterone production in men. This dual mechanism makes HUCOG 10000IU one of the most versatile injectable hormones used in reproductive medicine and endocrinology.
Bharat Serums manufactures HUCOG under strict WHO-GMP conditions. The urinary extraction process uses multiple chromatographic purification steps to isolate HCG while removing impurities, resulting in a product with high bioactivity and low immunogenicity.
Uses of HUCOG 10000IU
HUCOG 10000IU is prescribed across a range of clinical indications in both women and men. For a comprehensive overview, see our guide on HCG injection uses, dosage, and side effects.
Female Fertility: Ovulation Trigger
The most common use of HUCOG 10000IU is as a “trigger shot” in assisted reproduction. After controlled ovarian stimulation with FSH-based medications (such as Gonal-F or Menopur), a single injection of 5,000 to 10,000 IU of HCG is administered to induce final follicular maturation and ovulation. This is standard protocol in both IUI (intrauterine insemination) and IVF (in vitro fertilization) cycles. Ovulation typically occurs 36 to 40 hours after the trigger injection, allowing precise timing of insemination or egg retrieval.
HCG is also used for luteal phase support after embryo transfer, where repeated lower doses help maintain progesterone levels during the critical implantation window.
Male Hypogonadism
In men with hypogonadotropic hypogonadism — where the pituitary gland fails to produce adequate LH — HCG acts as a direct LH substitute. It stimulates Leydig cells in the testes to produce testosterone endogenously, often restoring both testosterone levels and spermatogenesis without the fertility-suppressing effects of exogenous testosterone.
TRT Adjunct (Testosterone Replacement Therapy)
Men on testosterone replacement therapy commonly experience testicular atrophy and suppressed sperm production because exogenous testosterone shuts down the hypothalamic-pituitary-gonadal axis. Co-administering low-dose HCG (typically 250 to 500 IU two to three times per week) maintains intratesticular testosterone production, preserves testicular volume, and supports ongoing fertility — a significant concern for younger men on TRT.
Cryptorchidism
In prepubertal boys with undescended testes, HCG therapy can stimulate testicular descent by promoting testosterone production within the testes. This non-surgical approach is typically attempted before orchiopexy and is most effective when the testes are palpable in the inguinal canal.
Post-Cycle Therapy (PCT)
After a cycle of anabolic steroids, endogenous testosterone production is suppressed. HCG is used during the early phase of post-cycle therapy to rapidly restore testicular function and testosterone output before transitioning to selective estrogen receptor modulators (SERMs) such as clomiphene or tamoxifen for full hypothalamic-pituitary recovery.
Dosage by Indication
The following table summarizes standard HUCOG dosing protocols. All doses should be individualized under medical supervision.
| Indication | Dose | Frequency | Duration |
|---|---|---|---|
| Female ovulation trigger | 5,000 – 10,000 IU | Single injection | One-time (per cycle) |
| Luteal phase support | 5,000 IU | Every 3 – 4 days | Up to 3 injections |
| Male hypogonadism | 1,000 – 2,000 IU | 2 – 3x per week | 3 – 6 months |
| TRT adjunct | 250 – 500 IU | 2 – 3x per week | Ongoing (with TRT) |
| Cryptorchidism | 500 – 1,000 IU | 2 – 3x per week | 4 – 6 weeks |
| Post-cycle therapy (PCT) | 1,000 – 2,000 IU | Every other day | 2 – 3 weeks |
How to Administer HUCOG 10000IU
HUCOG 10000IU is supplied as a lyophilized powder in a glass vial with a separate ampoule of bacteriostatic water or sterile sodium chloride solution. For detailed step-by-step mixing instructions, see our guide on how to mix HCG (Human Gonadotropin).
Reconstitution
- Wash hands thoroughly and clean the vial stopper and ampoule neck with an alcohol swab.
- Snap open the solvent ampoule and draw the entire contents into a syringe.
- Inject the solvent slowly into the HUCOG powder vial, directing the stream against the glass wall (not directly onto the powder) to avoid excessive foaming.
- Swirl gently until the powder dissolves completely. Do not shake. The resulting solution should be clear and colorless.
Injection Route
HUCOG 10000IU may be administered by intramuscular (IM) or subcutaneous (SC) injection. IM injection is the traditional route, typically into the upper outer quadrant of the gluteal muscle or the lateral thigh (vastus lateralis). SC injection into abdominal fat is increasingly common, particularly for lower-dose protocols such as TRT adjunct dosing, and studies show comparable bioavailability between the two routes.
Storage After Reconstitution
- Before mixing: Store the unreconstituted powder at room temperature (below 25°C / 77°F), protected from light.
- After mixing: Refrigerate at 2 – 8°C (36 – 46°F). Use within 30 days of reconstitution.
- Do not freeze. Discard any unused solution after 30 days or if it appears cloudy or discolored.
Side Effects
| Frequency | Side Effect | Notes |
|---|---|---|
| Common | Injection site pain, redness, or swelling | Usually resolves within 1 – 2 days |
| Common | Headache | Mild; manageable with OTC analgesics |
| Common | Fatigue and irritability | Transient, typically subsides with continued use |
| Common | Mood swings | Related to hormonal fluctuations |
| Common | Bloating and water retention | More pronounced at higher doses |
| Uncommon | Gynecomastia (in men) | HCG raises estradiol via increased testosterone aromatization; monitor E2 levels |
| Uncommon | Ovarian hyperstimulation syndrome (OHSS) in women | Risk increases with high follicle counts; requires medical monitoring |
| Rare | Thromboembolic events (blood clots) | Seek emergency care for sudden leg swelling, chest pain, or shortness of breath |
HCG Products Comparison at MedsBase
MedsBase carries several HCG products at different strengths and price points. The table below compares all available options.
| Product | Strength | Manufacturer | Type | Price (1 Vial) |
|---|---|---|---|---|
| HUCOG 5000IU | 5,000 IU | Bharat Serums | Urinary-derived | $15.00 |
| Puretrig 5000IU | 5,000 IU | Intas Pharmaceuticals | Recombinant (r-hCG) | $15.90 |
| Eutrig HP 5000IU | 5,000 IU | Samarth Life Sciences | Urinary-derived (HP) | $15.90 |
| ZyHCG HP 10000IU | 10,000 IU | German Remedies (Zydus) | Urinary-derived (HP) | $29.00 |
| HUCOG 10000IU | 10,000 IU | Bharat Serums | Urinary-derived | $32.00 |
Volume Pricing for HUCOG 10000IU
| Quantity | Total Price | Per Vial |
|---|---|---|
| 1 Vial | $32.00 | $32.00 |
| 2 Vials | $62.00 | $31.00 |
| 3 Vials | $90.00 | $30.00 |
| 10 Vials | $285.00 | $28.50 |
| 30 Vials | $810.00 | $27.00 |
Frequently Asked Questions
What is the difference between HUCOG 5000 and 10000?
The only difference is the amount of HCG per vial. HUCOG 5000IU contains 5,000 International Units, while HUCOG 10000IU contains 10,000 International Units. Both are manufactured by Bharat Serums using the same purification process. The 10,000 IU strength is typically used when a full 10,000 IU trigger dose is prescribed, or when patients prefer to draw multiple smaller doses from a single higher-concentration vial.
Does HUCOG need to be refrigerated?
Before reconstitution, HUCOG can be stored at controlled room temperature (below 25°C / 77°F) away from direct light. After mixing with the supplied solvent, the solution must be refrigerated at 2 – 8°C (36 – 46°F) and used within 30 days. Never freeze reconstituted HCG.
How do I mix HUCOG 10000IU?
Draw the entire contents of the supplied solvent ampoule into a syringe, then inject it into the vial containing the lyophilized powder. Direct the stream against the glass wall of the vial and swirl gently until dissolved. Do not shake vigorously. For a detailed walkthrough with images, see our HCG mixing guide.
Can men use HUCOG?
Yes. HCG is widely prescribed for men with hypogonadism, as an adjunct to testosterone replacement therapy to preserve testicular function and fertility, and during post-cycle therapy. In men, HCG mimics luteinizing hormone and stimulates the testes to produce testosterone endogenously.
How quickly does HUCOG work?
When used as an ovulation trigger, HUCOG induces ovulation within approximately 36 to 40 hours after injection. In men using HCG for hypogonadism or as a TRT adjunct, testosterone levels typically begin rising within 24 to 72 hours, though full clinical effects (improved energy, libido, and spermatogenesis) may take several weeks of consistent dosing.
Is HUCOG the same as Pregnyl?
HUCOG and Pregnyl (manufactured by Organon/MSD) are both urinary-derived HCG products containing the same active ingredient. They are therapeutically equivalent and used interchangeably in clinical practice. The primary differences are manufacturer, pricing, and regional availability. HUCOG is manufactured in India by Bharat Serums and is typically available at a significantly lower cost than Pregnyl.
Do I need a prescription?
HCG is classified as a prescription medication in most countries, including the United States, Canada, the United Kingdom, and the European Union. Regulations vary by jurisdiction. MedsBase ships internationally from India, where HUCOG is manufactured and regulated. Customers are responsible for understanding and complying with the import regulations of their own country.
What is the cheapest way to buy HUCOG?
The per-vial cost decreases significantly with larger quantities. A single vial of HUCOG 10000IU is $32.00, while the 30-vial pack brings the cost down to $27.00 per vial — a 16% discount. For patients needing the 5,000 IU strength instead, HUCOG 5000IU starts at just $15.00 per vial. If you specifically need 10,000 IU per vial, ZyHCG HP 10000IU at $29.00 per vial is the most affordable single-vial option at that strength.
Disclaimer
Clinics using HUCOG 10000IU Injection (hCG 10,000IU) for superovulation protocols sometimes prescribe the lower-dose Puretrig 5000IU Injection (hCG 5000IU) as the standard single trigger shot for IUI cycles where a full 10,000IU dose is not required.
HUCOG 10000IU Injection delivers a higher single-dose hCG load; for protocols that call for 5000 IU per shot — ovulation trigger, twice-weekly TRT support, or split fertility dosing — Eutrig HP 5000IU (highly purified human chorionic gonadotropin) matches the lower-strength requirement directly.
Related Alternatives
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- Qualifol 75IU Injection
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