Ketorol DT
✅ Fast pain relief
✅ Dissolvable tablets
✅ Easy to administer
✅ Anti-inflammatory properties
✅ Effective analgesic
Ketorol DT contains Ketorolac.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Ketorol DT?
Ketorol DT is a ketorolac tromethamine 10 mg orally disintegrating tablet for short-term relief of moderate to severe acute pain. Ketorolac is unusually potent for an oral NSAID and is often used as a non-opioid analgesic after surgery, dental procedures, renal colic, or significant soft-tissue injury. Usual dose: 10 mg every 4–6 hours with food, for a maximum of 5 days. Because of GI and renal risk, ketorolac is never used chronically — this is a short-course medicine only.
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Ketorol DT is an orally disintegrating tablet (DT) containing ketorolac tromethamine 10 mg — the only NSAID in the world labelled solely for short-term, strong pain relief. Ketorolac’s analgesic potency is comparable to low-dose morphine for moderate pain, which has given it a particular role in post-operative, post-dental, and renal-colic care where strong analgesia is needed without the sedation, respiratory depression, or addiction risk of opioids.
The orally disintegrating format dissolves on the tongue within seconds, making it useful when swallowing tablets is difficult — post-operative nausea, recent dental surgery, or heavy vomiting.
What Is Ketorol DT Used For?
- Short-term management of moderate to severe acute pain — post-operative, post-partum, post-dental
- Renal colic (kidney stone pain) — ketorolac is as effective as parenteral opioids in many studies
- Biliary colic
- Acute musculoskeletal injury — severe soft-tissue trauma
- Primary dysmenorrhoea — severe period pain unresponsive to first-line NSAIDs
- Acute migraine — second-line; particularly when triptans are contraindicated
Ketorolac is not indicated for minor or chronic pain. Using it for conditions where paracetamol or ibuprofen would be adequate unnecessarily exposes the patient to GI and renal risk.
How Does Ketorolac Work?
Ketorolac is a non-selective NSAID — it blocks both COX-1 (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2 (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.
The therapeutic chain of events is the same for every NSAID:
- Tissue injury or inflammation releases phospholipids from cell membranes
- Phospholipase A₂ converts them to arachidonic acid
- Cyclooxygenase (COX-1/COX-2) converts arachidonic acid to prostaglandins — the molecules responsible for pain, swelling, and fever
- Ketorolac blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation
Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.
Ketorol DT Dosing
- Oral: 10 mg every 4–6 hours as needed, maximum 40 mg/day
- Maximum total duration (all routes combined): 5 days
- Elderly (> 65), body weight < 50 kg, or mild renal impairment: maximum 40 mg/day and total duration ideally ≤ 2–3 days
Do not exceed 5 days of continuous ketorolac therapy in any form. The risk of GI ulcer and kidney injury rises sharply beyond this window. Transition to an alternative analgesic (ibuprofen, diclofenac, or paracetamol) after day 5.
How to take: place the DT tablet on the tongue, allow it to disintegrate (5–15 seconds), swallow with saliva. No water needed. Take with food or milk when possible.
GI safety — read this before the first dose. Every NSAID, including Ketorol DT, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Ketorol DT with food, use the lowest effective dose for the shortest reasonable time, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.
Ketorolac-specific warnings: Because ketorolac is unusually potent per milligram, it carries a higher rate of GI ulcers, bleeds, and acute kidney injury than most other oral NSAIDs at comparable pain-relief doses. This is why the 5-day limit exists and must be observed.
Who Should Not Take Ketorol DT?
- Known hypersensitivity to Ketorolac or any NSAID
- Active or recurrent peptic ulcer, GI bleed, or GI perforation
- Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)
- Severe heart failure (NYHA class IV)
- Severe hepatic impairment (Child–Pugh C)
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)
- Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs
Ketorolac-specific:
- Suspected or actual cerebrovascular bleeding, haemorrhagic diathesis, incomplete haemostasis
- Current, recent, or high-risk GI ulcer or bleeding
- Concurrent use of other NSAIDs or aspirin
- Concurrent use of pentoxifylline or probenecid
- Volume depletion — correct first
- Labour and delivery (inhibits uterine contractions, may delay parturition)
- Paediatric use in most jurisdictions
Cardiovascular risk
All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.
Renal (kidney) safety
NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.
Side Effects of Ketorol DT
- Common: nausea, dyspepsia, abdominal pain, diarrhoea, headache, dizziness, drowsiness, sweating
- Uncommon but important: peptic ulcer, GI bleeding, acute kidney injury (especially in volume-depleted or elderly patients), hypertension, elevated liver enzymes
- Rare: severe hepatotoxicity, bronchospasm, Stevens-Johnson syndrome, anaphylaxis
Stop Ketorol DT immediately and seek medical care for: signs of GI bleeding (black tarry stools, coffee-ground vomit, severe abdominal pain), reduced urine output, facial swelling or breathing difficulty, or a widespread rash.
Ketorol DT vs Ketanov Injection
| Product | Route | Typical dose | Onset | Use |
|---|---|---|---|---|
| Ketorol DT 10 mg | Oral (DT) | 10 mg q4–6 h | 20–40 min | Moderate pain, home use, step-down from injection |
| Ketanov Injection 30 mg/ml | IM or IV | 30 mg q6 h (IM) | 10–30 min | Severe acute pain, in-hospital, ED, peri-operative |
Total ketorolac exposure from any combination of routes must not exceed 5 days.
Ordering & Delivery
MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred strength or pack size is out of stock, contact customer support for an ETA.
Medical disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.
Frequently Asked Questions
What is Ketorol DT used for?
Ketorol DT (ketorolac 10 mg orally disintegrating) is used for short-term relief of moderate to severe acute pain — post-operative, post-dental, renal colic, severe musculoskeletal injury, and severe dysmenorrhoea. Maximum 5 days.
Why is ketorolac limited to 5 days?
Ketorolac is unusually potent per milligram, which also means unusually high risk of GI ulcer, bleeding, and acute kidney injury with prolonged use. Regulatory labelling and clinical evidence both limit continuous therapy to 5 days.
Is Ketorol DT as strong as morphine?
At equivalent analgesic doses, ketorolac 10 mg orally is comparable to low-dose morphine for moderate pain in post-operative studies. It does not cause sedation, respiratory depression, or addiction, which is why it is useful as an opioid-sparing analgesic.
How fast does Ketorol DT work?
Onset of pain relief is usually 20–40 minutes after dissolving on the tongue. Peak effect at 1 hour. Duration of a single dose is about 4–6 hours.
Can I take Ketorol DT with paracetamol?
Yes. Ketorolac and paracetamol work on different pathways and are commonly combined for stronger acute pain relief. This is a standard post-operative strategy.
Can I take Ketorol DT with another NSAID?
No — this combination sharply raises GI bleed and kidney-injury risk. If you are on low-dose aspirin for cardioprotection, discuss with your doctor before starting ketorolac.
How do I take the orally disintegrating tablet?
Place the tablet on your tongue, let it dissolve in 5–15 seconds, and swallow with saliva. No water is needed. Take with food or milk when possible.
Can I drink alcohol while on Ketorol DT?
No. Alcohol with ketorolac greatly increases the risk of GI bleeding. Avoid alcohol throughout the course.
Is Ketorol DT safe in pregnancy?
No — particularly in the third trimester (risk of premature ductus arteriosus closure). In early pregnancy, paracetamol or morphine-equivalent analgesia is preferred over ketorolac.
What happens if I take Ketorol DT for more than 5 days?
Each additional day of continuous therapy raises the risk of GI ulcer, kidney injury, and hypertension. If pain persists, switch to ibuprofen, diclofenac, paracetamol, or a medical review — do not simply keep taking ketorolac.
What is the difference between Ketorol DT and Ketanov Injection?
Same molecule (ketorolac), different route. Ketorol DT is oral. Ketanov Injection is intramuscular or intravenous — faster onset, typically for inpatient or emergency use. Total ketorolac time (oral + injection combined) must not exceed 5 days.
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| Strength | 10 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
Ketorol DT
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