Nemocid
Nemocid (pyrantel pamoate 250 mg, Cipla) — depolarising-blocker anthelmintic for pinworm, roundworm, and hookworm. Pregnancy-acceptable single-dose 11 mg/kg therapy with minimal systemic exposure.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer — What is Nemocid?
Nemocid is an oral pyrantel pamoate 250 mg tablet from Cipla. Pyrantel is the over-the-counter pinworm and roundworm agent in many countries (US, UK Combantrin) and works by depolarising parasite neuromuscular junctions — the worm is paralysed and passed in stool. Standard adult dose: 11 mg/kg as a single dose (max 1 g), repeated in 2 weeks for pinworm.
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What is Nemocid?
Nemocid is pyrantel pamoate 250 mg from Cipla. Pyrantel pamoate is a depolarising neuromuscular blocking agent specifically designed for parasites, with negligible absorption from the gut so systemic side effects are uncommon. Available over the counter in many regulated markets, pyrantel is a longstanding alternative to the benzimidazoles (albendazole, mebendazole) for pinworm and roundworm.
Mechanism of action
Pyrantel pamoate is a depolarising neuromuscular blocker: it binds nicotinic acetylcholine receptors on parasite muscle, causing sustained depolarisation and spastic paralysis. The paralysed worm releases its grip on the gut wall and is passed in faeces. The mechanism is the opposite of piperazine, which causes flaccid paralysis — piperazine and pyrantel should not be combined as they antagonise each other.
Less than 15% of an oral dose is absorbed; peak plasma is at 1–3 hours; both unchanged drug and metabolites are excreted predominantly in faeces. Low systemic exposure means very few off-target effects.
Nemocid indications and dose
| Indication | Dose | Schedule |
|---|---|---|
| Pinworm (Enterobius) | 11 mg/kg (max 1 g) | Single dose, repeat at 2 weeks |
| Roundworm (Ascaris) | 11 mg/kg | Single dose |
| Hookworm (Ancylostoma, Necator) | 11 mg/kg daily | For 3 days for heavy infection |
| Trichostrongylus | 11 mg/kg | Single dose |
Approximate adult dose: 1–4 tablets depending on body weight (1 tablet = 250 mg pyrantel pamoate base). Take with or without food. Most preparations also exist as suspensions for paediatric weight-based dosing — ask if you need the suspension format.
Side effects
- Common: mild GI upset, nausea, abdominal cramps, transient diarrhoea
- Less common: headache, dizziness, drowsiness, rash, transient transaminase rise
- Rare: hepatic dysfunction (limited reports)
Drug interactions
- Piperazine — antagonises pyrantel (opposite mechanism); never combine
- Theophylline — pyrantel may modestly raise theophylline levels; monitor in long courses
- No clinically significant CYP interactions because systemic exposure is low
Contraindications
- Hypersensitivity to pyrantel pamoate
- Children < 2 years (consult paediatrician for off-label use)
- Significant hepatic impairment
- Pregnancy — first trimester avoidance recommended; later trimesters acceptable for moderate-to-heavy worm burden
Storage
Store Nemocid below 25°C, away from light and moisture. Keep out of reach of children.
Why order from MedsBase
Nemocid is supplied from a WHO-GMP certified manufacturer, packaged discreetly, and shipped worldwide. Every order is covered by our Reshipment Assurance Policy — you never wear the cost of a lost parcel.
Frequently Asked Questions
Why choose pyrantel over albendazole?
Pyrantel is over-the-counter in many countries, has a long pregnancy-safety record, has minimal CYP interactions, and almost no systemic exposure. Albendazole and mebendazole work for the same indications and cover whipworm too — pyrantel does NOT cover whipworm.
How quickly does Nemocid work?
Worms are paralysed within hours and passed in faeces over the next 24–72 hours. Pinworm symptoms (perianal itching) usually resolve within a week.
Should I treat the rest of the family?
Yes for pinworm. Treat all household members on the same day and repeat in 2 weeks. Otherwise reinfection is almost guaranteed.
Can I take Nemocid with food?
Yes — food does not impair efficacy because pyrantel works in the gut lumen.
Does Nemocid treat tapeworm?
No. Pyrantel is active against nematodes (roundworms) only — not tapeworm and not flukes. Use niclosamide or praziquantel for tapeworm.
Is Nemocid safe in pregnancy?
Pyrantel has one of the better pregnancy-safety records among anthelmintics. The first trimester is still typically avoided where possible. Discuss with a clinician.
What about whipworm?
Pyrantel does NOT treat whipworm reliably. For whipworm use albendazole 400 mg daily for 3 days.
How does pyrantel compare to mebendazole?
Both are first-line over-the-counter pinworm/roundworm agents. Mebendazole also covers whipworm; pyrantel does not. Mebendazole is a benzimidazole; pyrantel is a depolarising blocker. Cross-resistance is uncommon.
What if I miss the second dose?
Take it as soon as you remember. The 2-week timing exists to catch the next pinworm life cycle — if you delay by a few days the protocol still works, but a longer gap risks reinfection.
While Nemocid (pyrantel pamoate 250 mg) targets pinworm and roundworm via a neuromuscular mechanism, Wormentel (fenbendazole 222 / 500 mg) provides a complementary benzimidazole option covering Giardia and tapeworms for cases where pyrantel alone may be insufficient.
Patients taking Nemocid (pyrantel pamoate 250 mg) for pinworm or roundworm infection who subsequently test positive for strongyloidiasis are typically transitioned to Iverheal (ivermectin 3 / 6 / 12 mg), which acts by a distinct neuronal mechanism on susceptible nematode species.
Other Antiparasitic Medications
- Nemocid (pyrantel pamoate 250 mg)
- ABD 400 (albendazole 400 mg)
- Mebex (mebendazole 100 mg)
- Iverheal (ivermectin)
- Bendex Suspension (paediatric albendazole)
More options in Threadworm Treatment
Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 250 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet/s |
Nemocid
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