Susten Vaginal Gel
✅ Hormonal balance support
✅ Vaginal health maintenance
✅ Menopausal symptom relief
✅ Fertility enhancement
✅ Pregnancy support
Susten Vaginal Gel contains Progesterone.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
💡 Quick Answer
Susten Vaginal Gel is natural progesterone 8% vaginal gel, used for luteal phase support in IVF, endometrial preparation for frozen embryo transfer (FET), and threatened/recurrent miscarriage prevention (in specific subgroups per PRISM trial). Vaginal route provides high uterine bioavailability while bypassing hepatic first-pass, with less drowsiness and nausea than oral micronized progesterone.
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What Is Susten Vaginal Gel?
Susten Vaginal Gel is a natural progesterone vaginal gel at 8% concentration, delivered by single-use applicator sachet. The vaginal route achieves high local uterine concentration by preferential uterine uptake (the “first uterine pass” effect) while delivering less drug systemically — reducing drowsiness and GI side effects vs oral progesterone. Manufactured by Sun Pharma.
Clinical Uses
- Luteal phase support in IVF cycles: 90 mg gel daily starting at embryo transfer, continued through week 10–12 of confirmed pregnancy.
- Endometrial preparation for frozen embryo transfer (FET): programmed cycles using estradiol + vaginal progesterone.
- Threatened miscarriage in women with prior recurrent loss (PRISM trial subgroup with active bleeding and ≥3 prior miscarriages).
- Secondary amenorrhoea — off-label.
- Progesterone-deficient luteal phase in natural conception attempts — selected cases.
How to Apply
- Wash hands. Twist off the cap of the single-use applicator. Lie on your back.
- Insert the applicator into the vagina and squeeze the body to expel the gel. Discard the applicator.
- IVF/FET luteal support: 90 mg daily (one applicator) starting at embryo transfer; continue through week 10–12 of confirmed pregnancy.
- Best timing: same time daily, at bedtime is common — reduces leakage from upright activity.
- Some leakage is normal; use a panty liner. Do not douche.
- Avoid intercourse immediately after application; wait 6+ hours for best retention.
Vaginal vs Oral vs IM Progesterone
- Vaginal (this product): high uterine delivery, less drowsiness, convenient self-administration, some leakage.
- Oral micronized: convenient, sleep benefit, but low bioavailability and more GI effects.
- IM (susten-injection): highest and most reliable uterine levels, but painful injection site lumps.
Most IVF clinics use vaginal or IM progesterone for luteal support. Choice depends on convenience, cost, patient preference, and clinic protocol.
Side Effects
Common: vaginal discharge, leakage, mild burning at insertion, breast tenderness, breakthrough bleeding or spotting.
Less common: headache, fatigue (less than oral), abdominal cramping.
Rare: allergic reaction, cholestasis.
Who Should Not Use Susten Vaginal Gel
- Known hypersensitivity to progesterone or excipients
- Active VTE, DVT, PE
- History of breast or genital malignancy
- Active liver disease
- Undiagnosed vaginal bleeding
- Missed abortion / incomplete abortion (seek medical review)
Storage
Store at room temperature (below 25 °C). Do not freeze. Keep applicator sealed until ready to use. Keep out of reach of children.
Frequently Asked Questions
How long does leakage last?
Leakage for a few hours after application is normal. Use a panty liner. Applying at bedtime minimises visible leakage.
Can I use a tampon with Susten Vaginal Gel?
No — a tampon absorbs the drug. Use panty liners.
When do I stop during pregnancy?
Typically around week 10–12, when the placenta takes over progesterone production. Exact timing per your fertility specialist.
Is vaginal progesterone the same as oral?
Same molecule but different delivery. Vaginal achieves higher uterine concentration with less systemic exposure — better tolerated for daily use in luteal support.
Can I have intercourse while using Susten Vaginal Gel?
Yes, but avoid in the 6 hours after application to allow proper absorption.
Does vaginal progesterone work as well as IM?
Yes — modern IVF trials show comparable pregnancy rates with vaginal vs IM progesterone. Vaginal is generally better tolerated (no painful injections).
What if I miss a dose?
Apply as soon as you remember; continue normal schedule. Do not double-dose. Contact your fertility clinic for missed-dose protocol in IVF cycles — consistency matters for implantation.
Can my partner absorb progesterone from contact?
Minor exposure possible via vaginal secretions during intercourse. Not clinically significant at standard doses.
Related Women’s Health Products
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- Duphaston (Dydrogesterone 10 mg)
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- Naprosyn (Naproxen 250 mg)
⚕️ Medical Disclaimer: Information is educational and does not replace medical advice. Consult a clinician before starting, stopping, or changing any medication, particularly for cancer therapy, hormonal treatments, and prescription products.
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| Strength | 8% |
|---|---|
| Quantity | 1 Sachet/s, 2 Sachet/s, 3 Sachet/s, 6 Sachet/s |
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