Asthalin Respules
✅ Effective asthma management
✅ Convenient respule format
✅ Easy inhalation method
✅ Enhanced respiratory comfort
Contains Salbutamol
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Asthalin Respules?
Asthalin Respules are single-dose salbutamol (albuterol) 2.5 mg / 2.5 ml nebuliser solution ampoules from Cipla, delivered by a nebuliser machine and face mask or mouthpiece. Salbutamol is a short-acting beta-2 agonist (SABA) that relaxes bronchial smooth muscle within 1–5 minutes, lasting 4–6 hours. Used for acute asthma exacerbations, bronchospasm in COPD, and for patients who cannot use a handheld inhaler (small children, elderly, severe acute illness). Typical dose: 1 respule nebulised every 4–6 hours; in severe attacks, back-to-back doses can be given under medical supervision. Respules are preservative-free — once opened, use immediately. Not a controller — frequent use signals poor asthma control and requires escalation.
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What Are Asthalin Respules?
Asthalin Respules are single-use plastic ampoules of salbutamol (albuterol) nebuliser solution, each containing 2.5 mg of salbutamol sulphate in 2.5 ml of isotonic sterile saline, geproduceerd door Cipla. They are designed for use with a jet or ultrasonic nebuliser machine fitted with a face mask (infants, young children, acutely unwell adults) or mouthpiece (cooperative children and adults).
Salbutamol — known as albuterol in the United States — is a short-acting beta-2 agonist (SABA) and the workhorse reliever medication for asthma and reversible airflow obstruction worldwide. It is on the WHO List of Essential Medicines. Asthalin Respules are the nebulised form; the handheld metered-dose inhaler version is sold as Asthalin Inhaler (100 mcg / actuation). Abroad the same drug is sold as Ventolin Nebules (GSK), ProAir, en AccuNeb.
Asthalin Respules are preservative-free and packed as a twist-open ampoule designed to be emptied into the nebuliser cup immediately. Once open, any unused solution is discarded — the preservative-free formulation is safer for children and for patients with sulphite or benzalkonium chloride sensitivity.
How Do Asthalin Respules Work?
Salbutamol selectively activates beta-2 adrenergic receptors on the smooth muscle that rings the bronchial airways. When these receptors are activated, intracellular cyclic AMP rises, smooth muscle relaxes, and the airway lumen widens — this is bronchodilation. The effect starts within 1–5 minutes of nebulisation, peaks at around 30–90 minutes, and lasts 4–6 hours. Salbutamol also modestly inhibits mast-cell mediator release and reduces plasma exudation from postcapillary venules.
The nebulised route is chosen over a handheld inhaler when the patient is too breathless, too young or too tired to inhale forcefully from a metered-dose inhaler (even with a spacer), when large doses are needed, or when the delivery of additional wet oxygen alongside the drug is desirable. Nebulisation takes 5–10 minutes per dose vs. 5–10 seconds for an inhaler — the trade-off is ease of use in acute illness.
Toepassingen en Indicaties
- Acute asthma exacerbations — both adult and paediatric, when inhaler + spacer is not sufficient or feasible
- COPD exacerbations with acute bronchospasm
- Bronchospasm in bronchiolitis, RSV, post-viral wheeze (infants and toddlers)
- Exercise-induced bronchoconstriction unresponsive to inhaler use
- Pre-operative bronchodilation in asthmatic patients
- Nebulised relief for patients who cannot coordinate an inhaler — very young children, elderly, dementia, severe dyspnoea
Asthalin Respules are niet a controller or preventer — they do not reduce underlying airway inflammation. Patients using more than the equivalent of one SABA canister per month (or needing nebulised salbutamol more than 3× per week) have poorly-controlled asthma and need an ICS-based controller stepped up.
Asthalin Respules Dosage
| Age / Setting | Dosering | Frequentie |
|---|---|---|
| Adults and children ≥12 years | 2.5–5 mg (1–2 respules) | Every 4–6 hours as needed |
| Children 4–11 years | 2,5 mg (1 respule) | Every 4–6 hours as needed |
| Children 2–4 years | 1.25–2.5 mg (half to 1 respule) | Every 4–6 hours under medical supervision |
| Severe acute asthma (adult) | 5 mg back-to-back | Every 15–20 minutes × 3 doses under monitoring, then reassess |
| Severe acute asthma (child) | 2.5–5 mg back-to-back | Every 15–20 minutes × 3 doses under monitoring |
How to Use Asthalin Respules Properly
- Wash your hands and assemble a clean, dry nebuliser machine, cup, and mask or mouthpiece.
- Twist off the top of the respule and squeeze the full contents into the nebuliser medicine cup. Do not dilute unless instructed — the respule is already in isotonic saline.
- Attach the mouthpiece or mask and switch on the compressor. A fine mist should appear within seconds.
- Breathe normally through the mouthpiece with occasional deep breaths. If using a mask, ensure a tight seal over mouth and nose.
- Continue for 5–10 minutes until the cup sputters and no more mist is produced. Tap the cup gently to dislodge last drops.
- Rinse the cup and mouthpiece with clean water, shake dry, and air-dry on a clean paper towel. Do not use a cloth (lint).
- For children using a mask: hold the mask firmly to the face; “blow-by” from 1–2 cm off the face delivers only about 50% of the dose.
- Discard any unused respule solution — it is preservative-free.
Side Effects of Asthalin Respules
Common (dose-related, settle within 30–60 minutes):
- Fine tremor, especially of the hands
- Palpitations, increased heart rate (10–20 bpm rise)
- Hoofdpijn
- Dry mouth, throat irritation
- Muscle cramps
- Hyperactivity / agitation in young children
Minder vaak:
- Hypokalaemia — especially with high repeated doses, worsened by theophylline, steroids or loop diuretics
- Hyperglycaemia
- Lactic acidosis (rare, with continuous high-dose nebulisation)
- Insomnia when dosed late evening
Serious (stop and call emergency services):
- Severe allergic reaction / angio-oedema / anaphylaxis
- Paradoxical bronchospasm (worsening wheeze immediately after nebulisation)
- Cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia)
- Severe hypokalaemia with arrhythmia or muscle weakness
Waarschuwingen en voorzorgsmaatregelen
- Frequent Asthalin Respules use = poor asthma control. Needing nebulised salbutamol more than 3× per week means the underlying disease is not managed. Step up ICS-based controller therapy (Seretide, Foracort, Budecort).
- Always carry or be near a nebuliser — respules require a machine; they cannot be used as handheld-inhaler substitutes.
- Monitor potassium with repeated high doses, especially in combination with systemic corticosteroids, theophylline or loop diuretics.
- Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, severe heart failure.
- Diabetes: monitor glucose with repeated high doses.
- Children under 2 years: specialist decision — evidence for benefit in viral bronchiolitis is limited.
- Severe asthma attack: seek emergency help if (a) reliever does not relieve breathlessness within 10 minutes of first dose, (b) peak flow below 50% personal best, (c) difficulty speaking in full sentences, or (d) cyanosis / drowsiness.
- Zwangerschap en borstvoeding: use at the lowest effective dose. Inhaled salbutamol is preferred over nebulised for long-term maintenance during pregnancy.
Contra-indicaties
- Known hypersensitivity to salbutamol or any formulation excipient
- Tachyarrhythmias (uncontrolled) — relative
- Phaeochromocytoma — relative
- Pre-term labour — salbutamol is used parenterally as a tocolytic but not the nebule form; different indication
Geneesmiddelinteracties
| Interacting drug | Effect | Wat te doen |
|---|---|---|
| Non-selective beta-blockers (propranolol, timolol drops) | Block salbutamol action — can precipitate severe bronchospasm | Avoid; switch to cardioselective beta-blocker if essential |
| Loop or thiazide diuretics | Additive hypokalaemia | Monitor serum potassium |
| Systemic corticosteroids (prednisolone) | Additive hypokalaemia + hyperglycaemia — but commonly co-prescribed in acute asthma | Monitor electrolytes and glucose with repeat high doses |
| Theophylline / aminophylline | Additive tachycardia and hypokalaemia | Monitor heart rate and potassium |
| MAOIs and tricyclic antidepressants | Potentiate cardiovascular effects | Caution — monitor BP/HR |
| Digoxine | Hypokalaemia from high-dose salbutamol increases digoxin toxicity risk | Monitor potassium; check digoxin level if symptomatic |
Opslag
- Store below 25°C, protected from direct light.
- Keep respules in their original foil overwrap until immediately before use — once unwrapped, use within 3 months.
- Once a respule is opened, use immediately; discard any remainder — preservative-free.
- Do not refrigerate. Do not freeze.
- Keep out of reach of children.
Gerelateerde alternatieven op MedsBase
- Seretide Accuhaler (fluticasone + salmeterol DPI) — controller inhaler for asthma and COPD
- Asthalin Inhaler (salbutamol HFA 100 mcg) — reliever MDI
- Duolin Inhaler (salbutamol + ipratropium HFA) — COPD combination reliever
- Budecort Respules (budesonide nebuliser suspension) — nebulised preventer
- Foracort Inhaler (formoterol + budesonide DPI/HFA) — ICS-LABA combo
Veelgestelde vragen
Is Asthalin Respules the same as Ventolin Nebules?
Yes — the same salbutamol 2.5 mg / 2.5 ml formulation is sold as Ventolin Nebules (GSK) in the UK and Europe, as AccuNeb in the US, and as Asthalin Respules (Cipla) in India and much of Asia and Africa. Clinically interchangeable.
Can I use Asthalin Respules in a handheld inhaler?
Nee. Respules are liquid ampoules for a nebuliser machine. The handheld-inhaler version of salbutamol is Asthalin Inhaler (100 mcg per actuation in an HFA pressurised canister) — a different product with a different delivery device.
How often can I use a Asthalin Respules respule?
Up to every 4–6 hours as needed for maintenance. In a severe attack, back-to-back every 15–20 minutes for three doses under medical supervision. Using respules more than 3 times per week — outside an acute attack — means your asthma is not controlled and you need a preventer (ICS or ICS-LABA) stepped up.
Can I give Asthalin Respules to my baby?
In infants under 2, the evidence for benefit in viral bronchiolitis is mixed — many trials show no improvement in admission rates. For confirmed asthma or exercise-induced wheeze in toddlers 2–4 years, 1.25–2.5 mg via a tight-fitting paediatric face mask is the usual dose under specialist guidance. Always confirm the diagnosis and dose with a paediatrician.
What nebuliser machine should I use?
Any jet (compressor) nebuliser rated for 6–8 L/min airflow will deliver salbutamol effectively — common brands include Omron, Philips, Pari and Flaem. Ultrasonic nebulisers also work for salbutamol but are more expensive and noisier. Mesh nebulisers are quietest but require careful cleaning. Replace the nebuliser kit (cup, mask, tubing) every 6–12 months depending on use.
How long before Asthalin Respules starts to work?
Bronchodilation begins within 1–5 minutes of starting the nebulisation. Peak effect is at 30–90 minutes. Duration is 4–6 hours. If you feel no better 15 minutes after a full dose, seek urgent medical help — this may indicate a severe attack that needs systemic steroids, oxygen and possibly magnesium sulphate IV.
Can I mix Asthalin Respules with other nebulised drugs?
Ipratropium bromide (Duolin respules or standalone) is commonly co-nebulised with salbutamol in acute severe asthma and COPD. Budesonide (Budecort respules) can be added. Do not mix with antibiotics, DNase, colistin or hypertonic saline in the same cup — these go in separate nebulisation sessions.
Why am I shaky and racing after a dose?
Fine tremor and tachycardia are the normal beta-2 adrenergic effects of salbutamol and resolve within 30–60 minutes. They are dose-dependent — you will feel them more after a 5 mg back-to-back dose than a routine 2.5 mg single. Severe or persistent palpitations, chest pain, or a feeling of irregular heartbeat warrant immediate medical review.
Do I need to rinse my mouth like with Seretide?
Rinsing is most important for inhaled corticosteroid products (to prevent thrush and hoarseness). For pure salbutamol nebules, rinsing is optional — but still a good habit, especially when a face mask is used (a tiny amount of drug settles on facial skin too — wipe the face after).
Can I use Asthalin Respules during pregnancy?
Ja — uncontrolled asthma in pregnancy is more dangerous than salbutamol to both mother and fetus. Inhaled and nebulised salbutamol are Category C (animal data) but the millions of patient-years of use have shown no consistent teratogenic signal. During labour, IV salbutamol can affect fetal heart rate and maternal glucose, but the nebulised dose used for asthma is very small.
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Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 2,5 mg |
|---|---|
| Hoeveelheid | 30 Respules/s, 60 Respules/s, 90 Respules/s |
| Farmaceutische vorm | Respules |
| Fabrikant | Cipla Inc |
| Behandeling | Asthma, Chronic obstructive pulmonary disorder (COPD) |
| Generiek merk | Salbutamol |
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