Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, characterised by oligo-/anovulation, hyperandrogenism (acne, hirsutism), and polycystic ovarian morphology on ultrasound. Modern management targets the dominant clinical concern — cycle regulation, fertility, hirsutism / acne, insulin resistance / metabolic risk — with different agents for different goals.
Stocked option. Medroxyprogesterone (oral progestogen for cycle regulation in women not seeking contraception or pregnancy — typically 10 mg daily for 10–14 days at the start of each cycle to induce withdrawal bleed every 1–3 months and protect endometrium from unopposed oestrogen) is stocked as Deviry.
For other PCOS goals — see related categories. Combined oral contraceptive pills (COCPs) for cycle regulation + acne / hirsutism + contraception → Contraceptive Pill (drospirenone-based pills like Yaz or Yasmin first-line; cyproterone-acetate-containing Diane 35 for moderate-severe acne / hirsutism). Metformin for insulin resistance + cycle regulation + modest weight effect → Diabetesmedicatie. Anti-androgens (spironolactone, cyproterone) for hirsutism — consult prescriber. Ovulation induction for PCOS infertility (clomiphene, letrozole, gonadotropins) → Vruchtbaarheidssupplementen voor vrouwen. Acne treatment topicals → Behandeling van acne.
Important. PCOS is a clinical diagnosis (Rotterdam criteria — 2 of 3: oligo-/anovulation, hyperandrogenism, polycystic ovaries) — exclude pregnancy, thyroid dysfunction, hyperprolactinaemia, congenital adrenal hyperplasia, Cushing’s syndrome before diagnosis. Long-term cardiovascular and metabolic risk (type 2 diabetes, hypertension, sleep apnoea, NAFLD, endometrial cancer) is increased — annual review of weight, BP, lipids, HbA1c recommended. Weight loss of 5–10% (where applicable) restores ovulation in many women. Endometrial protection (regular withdrawal bleeds at least every 3 months) matters in women with prolonged amenorrhoea. All MedsBase products ship from WHO-GMP gecertificeerde fabrikanten with discreet packaging and are covered by our Reshipment Assurance Policy.