Acute and chronic pain is one of the most common reasons for seeking medication. The right choice depends on whether the pain is nociceptive (musculoskeletal injury, post-operative, dysmenorrhoea, dental), inflammatory (arthritis, gout flare, tendonitis), neuropathic (post-herpetic, diabetic, sciatica), visceral (renal colic, biliary), or vascular (migraine, cluster headache, claudication). MedsBase stocks WHO-GMP certified generics and well-known branded generics across every common analgesic class so you can match the drug to the pain mechanism rather than reaching for the same tablet for every complaint.
Non-selective oral NSAIDs — first-line for inflammatory and acute musculoskeletal pain in adults without GI/renal/CV contraindications. Brufen (ibuprofen 400) is the lowest-risk short-course choice; Voveran SR en Reactin SR (diclofenac 100 SR) deliver round-the-clock relief for chronic arthritis; Reactin (diclofenac 50 IR) suits short-course flares; Dynapar adds paracetamol to diclofenac for additive analgesia. Inmecin en Inmecin-R (indomethacin) remain the textbook drug for acute gout. Naprosyn (naproxen 250/500) is the longer-half-life NSAID favoured for sustained anti-inflammatory effect with the cleanest CV profile in the class. Pirox DT (piroxicam) suits chronic rheumatoid maintenance once daily. Ketorol DT en Ketanov Injection (ketorolac) are short-duration potent options for moderate-to-severe acute pain — maximum 5 days. Meftal en Meftal-P (mefenamic acid) are first-line for primary dysmenorrhoea.
COX-2-selective and preferential NSAIDs — lower GI risk in patients with prior peptic ulcer history. Celeheal (celecoxib) is the original celecoxib; Etoford en Etorlee (etoricoxib 60/90/120) are the high-potency COX-2 selective option for ankylosing spondylitis and gout. Etova (etodolac) shows 5–10-fold COX-2 preference. Melorise (meloxicam) sits between non-selective and selective. Nicip (nimesulide) is reserved for short courses with strict liver-monitoring rules.
NSAID + enzyme combinations reduce post-surgical and post-traumatic oedema. Nucoxia SP (etoricoxib + serratiopeptidase) and Intagesic MR (diclofenac + paracetamol + chlorzoxazone) are widely used after orthopaedic procedures.
Pure paracetamol (acetaminophen) — the safest first-line analgesic in pregnancy, paediatrics, NSAID-intolerant adults, and patients with peptic ulcer or renal disease. Calpol, Crocin Advance, Anacin (paracetamol — not the US aspirin+caffeine formula), and Paracip are interchangeable 500 mg / 650 mg paracetamol tablets from different manufacturers.
Topical NSAIDs and combination gels — effective for localised soft-tissue pain with dramatically lower systemic exposure. Voveran Emulgel (diclofenac 1%) and Pirox Gel (piroxicam) are the workhorse single-agent topicals; Nise Gel (nimesulide) and Flexabenz Gel (diclofenac + methyl salicylate + menthol + capsaicin) target bigger surface areas. Lidogab Gel (lidocaine + gabapentin) addresses peripheral neuropathic pain — KY/MI/TN/VA/WV state restriction applies. Prilox Cream (lidocaine + prilocaine, EMLA-equivalent) provides topical anaesthesia before minor procedures, tattoos, and venous access. Lox 10% Spray (lidocaine 10%) gives rapid topical anaesthesia of mucosal surfaces.
Centrally-acting muscle relaxants — for spasm-related musculoskeletal pain, often combined with an NSAID. Flexura (metaxalone) and Robinax (methocarbamol) are the lowest-sedation options. Flexabenz (cyclobenzaprine 5 IR) and Flexabenz ER (cyclobenzaprine 15 ER) are the most effective short-course relaxants but more sedating. Synaptol (tolperisone) targets central spasticity without sedation. Trinex (tizanidine) is preferred for spasticity in multiple sclerosis and spinal cord injury.
Triptans for acute migraine — selective 5-HT1B/1D agonists that abort the headache phase. Suminat (sumatriptan) is the original and most-studied; Rizact (rizatriptan) has the fastest onset; Zolmist Nasal Spray (zolmitriptan intranasal) bypasses GI absorption when nausea is prominent. Cotrip (amitriptyline) is not a triptan despite the name — it is a tricyclic used for chronic migraine prophylaxis and neuropathic pain.
Systemic corticosteroids — for severe inflammatory pain, gout flare unresponsive to NSAIDs, and acute autoimmune exacerbations. Dexona Tablet, Decdan, Decmax, en Dexona Injection are dexamethasone formulations of escalating potency; Hydrocort 100 Injection (hydrocortisone) and Cort-S Injection are short-acting steroid options. Mandatory taper after any course longer than 7–10 days to avoid adrenal crisis.
Proteolytic enzymes — Chymoral Forte (trypsin + chymotrypsin) and Emanzen Forte (serratiopeptidase) reduce post-operative oedema and inflammatory swelling.
Vascular-pain specialty — GTN Spray (sublingual nitroglycerin) for acute angina; Trental 400 (pentoxifylline) improves microcirculation in intermittent claudication.
All MedsBase products are sourced from WHO-GMP certified manufacturers and shipped worldwide with discreet packaging and secure checkout (credit card, crypto, bank transfer). Pain medication can be dangerous when self-managed beyond short courses or in the wrong patient — always discuss persistent pain, suspected gastric/renal/CV risk factors, pregnancy, and any chronic illness with a qualified clinician before starting a long-term regimen.