Anti-thrombotic medications prevent and treat blood clots — venous thromboembolism (deep-vein thrombosis, pulmonary embolism), atrial-fibrillation stroke prevention, mechanical heart valves, and arterial events such as myocardial infarction and ischaemic stroke. The MedsBase Anti-Coagulants catalogue groups three pharmacologically distinct families: vitamin-K antagonists (warfarin), direct oral anticoagulants (DOACs), and antiplatelet agents.
Vitamin-K antagonists. Warfarin remains the standard for mechanical heart valves and a valuable option in atrial fibrillation and venous thromboembolism where DOACs are contraindicated (severe renal impairment, antiphospholipid syndrome, advanced liver disease). It requires regular INR monitoring (target 2.0–3.0 for AF and VTE; 2.5–3.5 for mechanical mitral valves) and careful management of dietary vitamin K, antibiotics, NSAIDs, amiodarone, and many other interactors. We stock Warf (1, 2, 3, 5 mg) and Waf-5 (5 mg).
Direct oral anticoagulants (DOACs). DOACs are first-line for non-valvular atrial fibrillation stroke prevention and for VTE treatment in most patients, with the practical advantages of fixed dosing, no routine monitoring, and fewer food/drug interactions than warfarin. Rivaroxaban (factor Xa inhibitor, once-daily for AF and 15 mg twice-daily then 20 mg once-daily for VTE) is available as Xarelto 20. Apixaban (factor Xa inhibitor, twice-daily, lowest major-bleeding rate of the class in head-to-head AF trials) is available as Eliquis.
Antiplatelet agents. Antiplatelets prevent arterial thrombosis (post-MI, post-PCI, ischaemic stroke, peripheral arterial disease). Clopidogrel (P2Y12 inhibitor) is stocked as Clodict. Dual antiplatelet therapy (aspirin + clopidogrel) is the standard 6–12-month regimen after coronary stenting, then aspirin monotherapy for life unless contraindicated.
Heparin (parenteral). Unfractionated heparin (Stanhep 25, 5000 IU/mL) is used for hospital-initiated anticoagulation, peri-operative bridging, dialysis circuits, and acute VTE. Low-molecular-weight heparins (enoxaparin, dalteparin) are widely used for outpatient VTE prevention and treatment but are listed separately when in stock.
Antiparasitic agents. Note: this catalogue currently also contains a number of products from adjacent therapeutic areas — antiparasitics (Ivecop / Vermact ivermectin) are best browsed in our Threadworm Treatment category, and several blood-pressure agents (ramipril, olmesartan, losartan, propranolol, metoprolol) are properly listed in Heart & Blood Pressure Medication. We are reorganising this catalogue to keep anti-thrombotics together in one place.
Hoe te kiezen. For non-valvular AF stroke prevention and most VTE, a DOAC is preferred over warfarin (lower intracranial bleed rates, no monitoring) unless creatinine clearance is below 25–30 mL/min, the patient has triple-positive antiphospholipid syndrome, or a mechanical valve is present — in which case warfarin remains first-line. For arterial events, single antiplatelet (aspirin or clopidogrel) is the default secondary prevention; dual antiplatelet is time-limited and indication-driven.
Critical warnings. All anticoagulants carry bleeding risk; report unusual bruising, gum bleeding, blood in urine or stool, severe headache, or any trauma immediately. Do not combine with NSAIDs (ibuprofen, diclofenac, naproxen) without medical advice — significant bleed-risk amplification. Major surgery, dental extraction, or invasive procedures need planned interruption (5 days for warfarin, 24–48 hours for DOACs depending on renal function and bleed risk). Pregnancy: warfarin is teratogenic; DOACs are not recommended in pregnancy or breastfeeding — switch to LMWH under haematology guidance.
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