Nausea and vomiting have many causes — chemotherapy-induced (CINV), post-operative (PONV), motion sickness, gastroenteritis, vestibular disease, migraine, pregnancy, and gastroparesis. Modern antiemetics target different receptors (5-HT3, D2, H1, NK1) and matching the agent to the cause delivers the best response. The MedsBase Nausea Treatment catalogue carries all major drug classes, supplied by WHO-GMP gecertificeerde fabrikanten.
5-HT3 antagonists — first-line for CINV and PONV. Ondansetron is the gold standard for chemotherapy-induced and post-operative nausea, and a useful option for severe gastroenteritis-related vomiting. Stocked as Ondem tablets, Ondem MD orodispersible (for vomiting patients), Ondem Injection for IV/IM use, and the brand alternatives Onford en Emeset 4 ODT. Granisetron (longer half-life, single-dose CINV cover) as Granicip. Side-effects: headache, constipation, QT prolongation at high doses (avoid in long-QT patients).
D2 antagonists — useful for migraine, gastroparesis, and post-op. Metoclopramide (D2 antagonist with prokinetic effect — speeds gastric emptying, particularly useful for migraine-associated nausea, diabetic gastroparesis, post-op ileus) as Metopar. Prochlorperazine (phenothiazine D2 antagonist — particularly useful for vertigo, migraine, hyperemesis gravidarum) as Stemetil MD orodispersible. Domperidone (peripheral D2 antagonist — for functional dyspepsia and gastroparesis) as Dompewal Tablet and the antimotility-combined Vomistop. Both metoclopramide and domperidone are now time-restricted (5 days metoclopramide, 7 days domperidone in adults) per EMA / FDA guidance — tardive dyskinesia and QT-prolongation respectively.
Antihistamines — for motion sickness and vestibular nausea. Promethazine (H1 antagonist with strong anticholinergic and sedative effects — useful for motion sickness and pregnancy nausea) as Avomine. Doxylamine + pyridoxine (the FDA-approved first-line combination for nausea and vomiting of pregnancy) as Doxinate en Pregnidoxin NU.
Combinatiepakketten. The Medische noodkit bundles common acute-care medications including antiemetics for travel and unexpected illness.
Hoe te kiezen. Chemotherapy / post-operative / severe gastroenteritis nausea → ondansetron 4–8 mg orally or ODT, repeat after 8 hours. Pregnancy nausea → doxylamine + pyridoxine first-line; promethazine or ondansetron for refractory cases (specialist guidance). Motion sickness → cinnarizine, promethazine, or hyoscine patch (see Reisziektetabletten). Migraine-related nausea → metoclopramide or prochlorperazine alongside triptan / NSAID. Gastroparesis → metoclopramide short-course or domperidone time-limited. Vertigo → prochlorperazine, betahistine.
Belangrijk. Persistent nausea/vomiting (more than 48 hours), inability to keep fluids down, signs of dehydration (reduced urine, dizziness on standing), bloody vomitus, severe abdominal pain, severe headache, or new neurological symptoms warrant urgent medical assessment rather than self-medication. First-trimester pregnancy nausea is common and usually mild — but hyperemesis gravidarum (persistent vomiting with weight loss, ketosis, dehydration) needs hospital management. Long-QT patients, cardiac disease, severe electrolyte abnormalities, and concomitant QT-prolonging drugs change the safest antiemetic choice.
All MedsBase Nausea Treatment products ship from WHO-GMP gecertificeerde fabrikanten met discrete verpakking en vallen onder onze Reshipment Assurance Policy.