Clocip B Cream

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Clocip B Cream is een topical combination cream containing two complementary active ingredients: clotrimazole 1% w/w, a broad-spectrum imidazole antifungal, and beclomethasone dipropionate 0.025% w/w, a moderate-potency topical corticosteroid. Supplied in a convenient tube for external use, it is designed for fungal skin conditions where itch, redness, and inflammation are significant alongside the infection itself.

The combination approach resolves a common clinical problem: pure antifungal creams treat the fungus but leave the inflammation to settle on its own, which can take days. Pure steroids calm the inflammation but can worsen untreated fungal infection. Combining both delivers fast symptom relief plus active treatment, which is why Clocip B and similar combinations are among the most-prescribed dermatology products worldwide.

What Is Clocip B Cream?

Clocip B is a prescription topical combination used for inflamed fungal skin conditions. It contains:

• Clotrimazole 1% — an imidazole antifungal active against dermatophytes (Trichophyton, Microsporum, Epidermophyton), yeasts (Candida albicans), en Malassezia furfur
• Beclomethasone dipropionate 0.025% — a moderate-potency topical corticosteroid that reduces redness, itching, swelling, and scaling

Clocip B Cream is most commonly prescribed for:

• Tinea corporis (ringworm on the body)
• Tinea cruris (jock itch — groin ringworm)
• Tinea pedis (athlete’s foot)
• Tinea manuum (hand ringworm)
• Candidal intertrigo — fungal infection in skin folds (under breasts, groin, axillae)
• Inflamed seborrhoeic dermatitis where a Malassezia component is suspected
• Napkin (diaper) dermatitis with candidal overgrowth — short courses only, under paediatric supervision

How Does Clocip B Cream Work?

The two active ingredients target the fungal infection and the inflammatory response in parallel:

• Clotrimazole inhibits the fungal cytochrome P450 enzyme 14-α-demethylase. This blocks conversion of lanosterol to ergosterol — the primary sterol in fungal cell membranes. The result is a disrupted, leaky fungal membrane and cell death
• Beclomethasone dipropionate binds intracellular glucocorticoid receptors, moving to the nucleus and suppressing transcription of pro-inflammatory cytokines, chemokines, and adhesion molecules. Clinically this translates to rapid reduction in itch, redness, and swelling
• Onset of antifungal action is gradual — expect clinical improvement over 1–2 weeks. Anti-inflammatory relief is usually felt within 24–48 hours

Toepassingen en Indicaties

• Inflamed dermatophyte infections (tinea) — especially when initial treatment with antifungal alone has failed or when inflammation is prominent
• Candidal intertrigo in skin folds
• Otitis externa with fungal component — under medical supervision, in the outer ear canal only
• Eczematised fungal infections — short course to calm inflammation while antifungal clears the organism

Clocip B Cream Dosage and Application

How to Apply Clocip B Cream Properly

• Wash and dry the affected skin gently before each application
• Apply a thin layer — a pea-sized amount covers about a hand’s surface. More is not better
• Rub in until absorbed; do not occlude with tight bandages (increases steroid absorption)
• Wash hands after application (unless hands are the treatment site)
• Continue for 1 week after visible clearance to prevent relapse
• Do niet apply to the face, groin, or skin folds for more than 5–7 days without medical review
• Do niet cover with plastic dressings or nappies — occlusion amplifies steroid absorption and can cause systemic effects in infants
• If symptoms worsen or don’t improve within 2 weeks, stop and consult your doctor — the problem may not be fungal

Side Effects of Clocip B Cream

Short courses (1–2 weeks) are usually well tolerated. Most side effects relate to the corticosteroid component and emerge with prolonged or inappropriate use.

Stop and seek medical review if the area becomes visibly thinner, develops stretch marks, worsens after 2 weeks of use, or if a strong allergic-type rash develops.

Waarschuwingen en voorzorgsmaatregelen

• Not for bacterial or viral skin infections. Clocip B contains no antibacterial or antiviral ingredient. Do not use on impetigo, herpes, chickenpox, or viral warts
• Facial use. Strictly short-term (≤7 days) — prolonged use causes steroid rosacea and perioral dermatitis
• Skin folds and genital area. These are natural occlusive sites and amplify steroid absorption — keep courses short
• Infants and young children. Higher skin-surface-to-body-weight ratio means greater systemic absorption. Use only under paediatric guidance
• Pregnancy / breastfeeding. Short-term small-area use is generally considered safe; avoid application to the breast area when breastfeeding
• Tinea incognito. When tinea is treated with steroids alone it can look improved but continues to spread under the steroid cover. Adding clotrimazole in this combination reduces that risk, but if the rash’s margins continue advancing, the diagnosis should be reviewed
• Eye contact. Not for ophthalmic use; rinse thoroughly if accidental eye contact occurs

Contraindications — Who Should NOT Use Clocip B Cream

• Hypersensitivity to clotrimazole, beclomethasone, or any excipient
• Tuberculous, syphilitic, or viral skin infections (chickenpox, herpes simplex, vaccinia)
• Rosacea and perioral dermatitis — steroids trigger or worsen these
• Acne vulgaris — steroids cause acneiform flares
• Ulcerated skin or open wounds
• Use under occlusive dressings without medical supervision

Geneesmiddelinteracties

Topical clotrimazole and beclomethasone have minimal systemic absorption in normal use, so clinically important drug interactions are uncommon.

Tell your doctor about all topical products you are using before starting Clocip B, including cosmetics, moisturisers, and over-the-counter steroids.

Wat te doen bij overdosering

Topical overdose (excessive application or accidental ingestion) is unlikely to cause acute toxicity with one tube’s content. Prolonged high-surface-area use can cause systemic steroid effects — adrenal suppression, Cushingoid features. If a small child ingests the cream, seek medical advice.

Bewaaradvies

• Bewaren onder 30 °C op een droge plaats, uit direct zonlicht
• Recap the tube tightly after use
• Do not freeze
• Buiten bereik van kinderen en huisdieren houden
• Discard any unused cream 6 months after first opening even if product remains

Gerelateerde alternatieven op MedsBase

Looking for related antifungal or topical options?

• Clocip — clotrimazole 1% alone, when inflammation is not a prominent feature
• Betnovate-N Cream — betamethasone + neomycin for inflamed bacterial skin infections
• Browse all Anti-Fungal treatments →

Veelgestelde vragen

What is Clocip B Cream used for?

Clocip B Cream is a topical antifungal + corticosteroid used for fungal skin infections with prominent inflammation — including tinea (ringworm, athlete’s foot, jock itch), candidal intertrigo, and inflamed seborrhoeic dermatitis.

How fast does Clocip B Cream work?

The anti-inflammatory effect (itch, redness) is usually noticeable within 24–48 hours. The antifungal effect takes longer — expect visible clearance over 1–2 weeks.

Is Clocip B the same as Clocip?

Nee. Clocip contains clotrimazole alone — an antifungal without a steroid. Clocip B adds beclomethasone dipropionate for faster symptom relief. Use Clocip when inflammation is mild; use Clocip B when itch and redness are prominent.

Can I use Clocip B Cream on my face?

Only short-term (≤5–7 days) and sparingly. The facial skin absorbs steroids faster and is prone to steroid-induced rosacea and perioral dermatitis with prolonged use.

Can I use Clocip B on my child?

Use in children should be under medical guidance. Smaller body surface-to-weight ratio means higher systemic steroid absorption. Short courses (3–5 days) in skin folds may be prescribed but should not be applied under nappies or occlusive dressings.

How long can I use Clocip B Cream?

Typical courses are 2 weeks. If symptoms persist beyond 2 weeks, stop and consult a doctor — the diagnosis may need revisiting. Continuous use beyond 4 weeks risks skin atrophy, telangiectasia, and steroid-induced acne.

Can I use Clocip B for acne?

Nee. The steroid component can trigger or worsen acne, rosacea, and perioral dermatitis. Clocip B is not a suitable acne treatment.

Can I use Clocip B under a nappy or occlusive dressing?

Not without medical advice. Occlusion dramatically increases steroid absorption, which is particularly risky in infants and in large-area use. Use standard open dressing only.

Will Clocip B treat a bacterial skin infection?

No — neither active ingredient is antibacterial. If you have impetigo or infected eczema with bacterial involvement, an antibiotic combination (e.g. Betnovate-N Cream or a separate antibiotic) is needed instead.

What if my rash comes back after stopping Clocip B?

Recurrent fungal infections often indicate a reservoir (athlete’s foot recurring from infected shoes, candidal intertrigo from persistent moisture). Address the source: keep the area clean and dry, change footwear, treat all affected household members, and consider a longer course or switch to an oral antifungal (e.g. terbinafine, fluconazole).

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