Cabgolin
✅ Prolactin level normalization
✅ Menstrual cycle regulation
✅ Enhanced fertility support
✅ Breast milk reduction
Cabgolin contains Cabergoline
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Quick Answer — What is Cabgolin?
Cabgolin je perorální cabergoline tablet in 0.25 mg and 0.5 mg strengths — a long-acting dopamine D₂ receptor agonist používaná k léčbě hyperprolactinaemia, prolactin-secreting pituitary adenomas (prolactinomas), and for suppression of lactation. Typical dosing is 0.25–1 mg twice weekly. Cabergoline is ne hormone-replacement therapy — it reduces prolactin levels and restores normal gonadal axis function. Clinically equivalent to Pfizer’s Dostinex®.
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Cabgolin is Sun Pharma’s cabergoline tablet — a long-acting selective dopamine D₂ receptor agonist derived from ergot alkaloids. Cabergoline has been available since 1993 and is now the first-line treatment for hyperprolactinaemia a prolactinomas (the most common type of functioning pituitary tumour).
Cabgolin contains the same active ingredient at the same strengths as Pfizer’s branded Dostinex®. Its long plasma half-life (~65 hours) allows for twice-weekly dosing, which is much more convenient than the older alternative bromocriptine (taken daily or twice daily).
What Is Cabgolin?
Cabgolin is a prescription dopamine D₂ agonist indicated for:
- Idiopathic hyperprolactinaemia — elevated prolactin without an identified cause
- Microprolactinoma — pituitary adenomas <10 mm secreting prolactin
- Macroprolactinoma — pituitary adenomas ≥10 mm secreting prolactin (cabergoline often shrinks these, avoiding surgery)
- Lactation suppression — when required immediately postpartum or for established lactation (single 1 mg dose postpartum; 0.25 mg twice daily for 2 days if established)
- Parkinson’s disease — off-label or historic use; newer non-ergot dopamine agonists are preferred
- Prolactin-related female infertility — restores ovulatory cycles
- Male hypogonadism / erectile dysfunction due to hyperprolactinaemia
How Does Cabgolin Work?
Prolactin is released from the anterior pituitary and is normally kept in check by dopamine (also called prolactin-inhibiting factor) travelling from the hypothalamus:
- Cabergoline binds dopamine D₂ receptors on the pituitary lactotroph cells
- Tento suppresses prolactin synthesis and release, and in prolactinoma it also shrinks the tumour cells
- Normal prolactin levels are typically restored within 2–4 weeks
- Once prolactin normalises, downstream effects resolve: return of menses in women, resumption of ovulation and fertility, restoration of libido and testosterone in men, and cessation of galactorrhoea
- Cabergoline’s very long half-life (~65 hours) allows twice-weekly dosing — a major practical advantage over bromocriptine
In lactation suppression, cabergoline rapidly blocks post-delivery prolactin surge so breast engorgement and milk production are minimised.
Cabgolin Dosage and Administration
| Indikace | Dávka | Schedule |
|---|---|---|
| Hyperprolactinaemia (starter) | 0.25 mg twice weekly | e.g. Monday and Thursday, at bedtime with food |
| Hyperprolactinaemia (target) | 0.5–1 mg twice weekly | Titrate up at monthly intervals based on prolactin level |
| Macroprolactinoma (large tumour) | 1–3 mg twice weekly | Higher-dose protocol; endocrinologist supervision |
| Lactation prevention (postpartum) | 1 mg (four 0.25 mg tablets) | Single dose within 24 hours of delivery |
| Suppression of established lactation | 0.25 mg twice daily | For 2 days (total 1 mg) |
| Parkinson’s disease (historic) | 2–6 mg once daily | Newer non-ergot dopamine agonists now preferred |
| Elderly | Start at 0.25 mg once weekly | Slower titration |
| Porucha funkce jater | Reduce dose; monitor closely | Cabergoline is hepatically cleared |
| Maximum weekly dose | 3 mg | Higher doses carry valvular heart disease risk |
How to Take Cabgolin Properly
- Swallow tablet whole with water; take with food and at bedtime to minimise nausea and dizziness
- Choose two fixed days of the week and stick to them (e.g. Monday and Thursday)
- Sledujte prolactin levels at 4–6 weeks after starting and after every dose change
- Once prolactin is normal and stable, continue for at least 2 years before attempting gradual dose reduction under endocrinology supervision
- Monitor for impulse-control disorders (gambling, hypersexuality, compulsive shopping, binge eating) — report any behavioural change
- Echocardiography is recommended at baseline and periodically in patients on high-dose long-term therapy (>2 mg weekly for prolactinoma, or any dose for Parkinson’s)
- Do not stop abruptly in prolactinoma — tumour regrowth can occur
Side Effects of Cabgolin
| Závažnost | Vedlejší účinek |
|---|---|
| Běžné (≥1 z 10) | Nausea, headache, dizziness, fatigue, constipation (usually settles in 2–4 weeks) |
| Běžné (≥1 ze 100) | Orthostatic hypotension (especially first dose), abdominal pain, mood changes, hot flushes, breast pain, depression |
| Méně časté | Palpitations, skin rash, paraesthesia, insomnia, peripheral oedema |
| Vzácné, ale závažné | Impulse-control disorders (pathological gambling, hypersexuality, compulsive shopping), valvular heart disease (fibrotic changes — dose-related, rare at <3 mg/week), pulmonary or retroperitoneal fibrosis (historic concern from Parkinson’s doses), hepatic dysfunction |
Impulse-control behaviour is a dopamine-agonist class effect. It can develop subtly — partners and family often notice before the patient does. Always report any new compulsive or unusual behaviour to your doctor. The effect reverses on dose reduction or discontinuation.
Varování a opatření
- Valvular heart disease. Long-term high-dose cabergoline (historically for Parkinson’s at 3–6 mg/day) caused fibrotic cardiac valve changes. At the much lower prolactinoma doses (<3 mg/week) this risk is very low but screening echocardiography is still recommended at baseline and every 1–2 years in chronic use
- Impulse-control disorders. Patients, partners, and families should be informed; monitoring is essential
- First-dose hypotension. Take the first dose at home, at bedtime, with food. Avoid alcohol around first dose
- Pregnancy. Stop once pregnancy is confirmed — fetal safety data is limited but the drug itself is not clearly teratogenic. Restart if tumour regrowth becomes an issue under specialist guidance
- Breastfeeding. Contraindicated while breastfeeding — cabergoline suppresses lactation and passes into breast milk
- Psychiatric history. Use cautiously in patients with severe depression or psychosis — rarely precipitates mood episodes
- Alkohol. Amplifies first-dose orthostatic hypotension; limit in early weeks of treatment
- Renal / hepatic dysfunction. Reduce dose and monitor in significant impairment
Contraindications — Who Should NOT Take Cabgolin
- Known hypersensitivity to cabergoline, ergot alkaloids, or any excipient
- Uncontrolled hypertension (>170/100 mmHg)
- Pre-existing valvular heart disease
- History of fibrotic disorders (pulmonary, retroperitoneal, pericardial)
- Postpartum hypertension or pre-eclampsia
- Těžké jaterní poškození
- Breastfeeding (unless lactation suppression is the goal)
Interakce s léčivy
| Léčivo / Třída | Interakce |
|---|---|
| Dopamine antagonists (antipsychotics, metoclopramide, prochlorperazine) | Directly antagonise cabergoline — reduce efficacy; choose alternative anti-emetic |
| Macrolide antibiotics (erythromycin, clarithromycin) | May raise cabergoline plasma levels — use cautiously |
| Antihypertenziva | Additive hypotension — monitor BP |
| Other ergot derivatives | Do not combine |
| Alkohol | Amplifies dizziness and hypotension |
Pokyny k uchovávání
- Store below 25 °C in a dry place, away from direct sunlight and moisture
- Uchovávejte v původním blistrovém obalu
- Uchovávejte mimo dosah dětí
- Nepoužívejte po uplynutí data expirace
Související alternativy na MedsBase
- Ropark — ropinirole, a non-ergot dopamine agonist for Parkinson’s and restless legs
- Pramirol — pramipexole, another non-ergot dopamine agonist
- Browse all Women’s Health medications →
Často kladené dotazy
What is Cabgolin used for?
Cabgolin (cabergoline) is used to treat hyperprolactinaemia, prolactinomas (prolactin-secreting pituitary tumours), and for suppression of breast-milk production. It restores normal menstrual cycles in women, fertility and testosterone in men with prolactin-related hypogonadism, and can shrink large prolactin-secreting pituitary tumours.
How fast does Cabgolin work?
Prolactin levels typically fall into the normal range within 2–4 weeks. Menstrual cycles usually return within 6–12 weeks and fertility within a similar window. Tumour shrinkage (in macroprolactinomas) is seen on MRI by 3–6 months.
Is Cabgolin the same as Dostinex?
Yes — both contain cabergoline at the same strengths. Cabgolin is the Sun Pharma brand; Dostinex is Pfizer’s brand. Clinically equivalent.
Why is Cabgolin dosed only twice a week?
Cabergoline has a very long plasma half-life (~65 hours), so twice-weekly dosing maintains adequate levels. This is one of its major advantages over bromocriptine, which must be taken daily or twice daily.
Does Cabgolin cure prolactinoma?
Cabergoline is usually a suppressive treatment — it normalises prolactin and shrinks the tumour while being taken. After 2 or more years of well-controlled prolactin on a stable dose, a gradual taper under specialist supervision can sometimes lead to durable remission, particularly for smaller tumours.
Can Cabgolin help me get pregnant?
Yes — if your infertility is caused by hyperprolactinaemia, cabergoline typically restores ovulatory cycles. Many women conceive within months of starting. Once pregnancy is confirmed, stop cabergoline unless your endocrinologist advises otherwise.
Can I take Cabgolin while breastfeeding?
Ne — cabergoline suppresses lactation. It is specifically used for lactation suppression and is contraindicated while breastfeeding.
Will Cabgolin affect my behaviour?
A small but important proportion of patients on dopamine agonists develop impulse-control disorders — pathological gambling, hypersexuality, compulsive shopping, or binge eating. Report any new compulsive behaviour to your doctor. The effect reverses with dose reduction or discontinuation.
Do I need echocardiography on Cabgolin?
Yes — a baseline echocardiogram before starting and periodic follow-up (every 1–2 years) is recommended for anyone on long-term cabergoline, to screen for rare valvular fibrotic changes. Risk is low at typical prolactinoma doses (<3 mg/week) but monitoring remains standard practice.
How should I take Cabgolin if I miss a dose?
If the missed dose is within a day, take it as soon as you remember. If close to the next scheduled dose, skip the missed one — do not double up. Missing an occasional dose does not significantly affect prolactin control given the long half-life.
Can I drink alcohol on Cabgolin?
Moderate alcohol is usually tolerated after the first few weeks. Early in treatment, alcohol compounds first-dose dizziness and orthostatic hypotension — minimise until you know how you tolerate the drug.
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Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 0.25 mg, 0.5 mg |
|---|---|
| Množství | 12 Tablet/s, 24 Tablet/s, 36 Tablet/s |
| Léková forma | Tablet/s |
| Výrobce | Sun Pharma |
| Léčba | Increased prolactin levels, Acromegaly |
| Generická značka | Cabergoline |
Cabgolin
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Cabgolin
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