Febutaz
✅ Controls Uric Acid
✅ Prevents Gout Attacks
✅ Reduces Joint Pain
✅ Improves Kidney Function
✅ Enhances Overall Health
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
Rychlá odpověď
Febutaz obsahuje febuxostat 40 mg / 80 mg made by Sun Pharma. It is used for long-term lowering of serum uric acid in adults with chronic gout (urate-lowering therapy) — including those with urate kidney stones. Take exactly as directed by your clinician — do not adjust the dose yourself.
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⚠ Cardiovascular caution — allopurinol is the preferred first-line urate lowering therapy
The 2018 CARES trial showed higher cardiovascular and all-cause mortality on febuxostat versus allopurinol in patients with gout AND established cardiovascular disease. The 2020 FAST trial found no excess in a European population. Major guidelines (ACR 2020, EULAR 2016) recommend allopurinol as first-line; febuxostat is reserved for patients who cannot tolerate or do not reach target on allopurinol, or who have HLA-B*5801 contraindications. Discuss cardiovascular history with your prescriber before starting.
What Febutaz is and how it works
Febutaz contains febuxostat, , non-purine selective xanthine oxidase inhibitor. By blocking xanthine oxidase, it stops the conversion of hypoxanthine and xanthine to uric acid, lowering serum urate. Unlike allopurinol (a purine analogue), febuxostat is metabolised mostly in the liver, so it can be used in mild-to-moderate renal impairment without dose adjustment.
Febutaz is licensed for the chronic management of hyperuricaemia in patients with gout, including tophaceous gout. It is not a treatment for an acute gout flare; flares are managed with NSAIDs, colchicine or corticosteroids.
Dose and how to take it
| Patient group | Recommended dose |
|---|---|
| Adults with chronic gout — starting dose | 40 mg jednou denně |
| Step-up after 2–4 weeks if serum urate > 0.36 mmol/L (6 mg/dL) | Increase to 80 mg once daily |
| Těžké renální postižení (eGFR <30) | Use cautiously; data limited; consider alternative |
| Těžké jaterní poškození (Child-Pugh C) | Avoid — not studied |
| Tophaceous gout / very high baseline urate | May need 80 mg from start under specialist supervision |
Take at the same time each day, with or without food. Continue indefinitely — gout is a chronic condition. Target serum urate is usually < 0.36 mmol/L (< 6 mg/dL); for tophaceous gout, < 0.30 mmol/L (< 5 mg/dL) for tophus dissolution.
✅ Co-prescribe acute-flare prophylaxis for the first 6 months
Starting any urate-lowering therapy can trigger gout flares as crystals shed from joints. ACR and EULAR guidelines recommend prophylactic colchicine 0.5–1 mg/day nebo NSAID for at least 3–6 months when starting febuxostat — do not stop the febuxostat if a flare occurs.
Vedlejší účinky
| Side effect | Frekvence | Poznámky |
|---|---|---|
| Gout flare (early therapy) | Very common in first 6 months | Use prophylaxis; do not stop febuxostat |
| Liver enzyme rise | Běžné | Check LFTs at baseline, 2 months, then periodically |
| Bolest hlavy | Běžné | Usually mild |
| Diarrhoea, nausea | Běžné | Užívejte s jídlem |
| Vyrážka | Méně časté | Stop if widespread; rare reports of severe cutaneous reactions |
| Cardiovascular events (in established CVD) | CARES signal | Discuss with cardiologist; consider allopurinol |
| Hepatotoxicity (severe) | Vzácné | Stop and seek review |
Interakce léků
| Combination | Účinek | Action |
|---|---|---|
| Azathioprine, mercaptopurine | Major rise in 6-mercaptopurine levels — bone-marrow toxicity | Avoid combination |
| Theofylin | Theophylline levels may rise | Sledujte |
| NSAIDs, colchicine, low-dose aspirin | Used together for flare prophylaxis — standard pattern | Not a true interaction; co-prescribe |
| Diuretics (thiazide, loop) | Raise serum urate — may need higher febuxostat dose | Monitor target urate level |
| Warfarin | No clinically significant interaction | Standard INR monitoring |
Who should not take Febutaz
- Concurrent azathioprine or mercaptopurine
- Těžké jaterní poškození (Child-Pugh C)
- Established cardiovascular disease — allopurinol preferred unless allopurinol cannot be used
- Acute gout flare (treat the flare first; start febuxostat 2 weeks later if naive)
- Asymptomatic hyperuricaemia without gout history (no benefit)
- Pregnancy / breastfeeding (no human data)
Why febuxostat appears in a Bladder & Prostate category
Hyperuricaemia is a leading cause of uric-acid kidney stones and contributes to chronic urate nephropathy. Lowering serum urate — via febuxostat or allopurinol — reduces stone recurrence in patients with documented urate stones. Uric-acid stones also benefit from urinary alkalinisation (potassium citrate) and high fluid intake. If your indication is stones rather than gout, your urologist or nephrologist will combine febuxostat with citrate, hydration and dietary purine restriction.
Často kladené dotazy
What is the right serum urate target?
< 0.36 mmol/L (< 6 mg/dL) for typical gout. < 0.30 mmol/L (< 5 mg/dL) when there are visible tophi or recurrent stones — lower targets dissolve crystals faster.
Why might I get more flares after starting?
Lowering serum urate destabilises the crystal surface. Crystals shed and trigger flares. This is why colchicine 0.5–1 mg/day or an NSAID is co-prescribed for the first 3–6 months. Do not stop febuxostat — stopping makes future flares worse.
Should I be on allopurinol instead?
Allopurinol is first-line per ACR 2020 / EULAR 2016 guidelines. Febuxostat is preferred when allopurinol cannot reach target despite proper titration, when allopurinol is not tolerated, or when HLA-B*5801 testing flags severe-cutaneous-reaction risk (relevant in some Asian populations).
What about the cardiovascular signal?
CARES (2018, US) showed higher CV and all-cause mortality vs allopurinol in patients with established CVD. FAST (2020, Europe) found no excess in patients without prior CVD. Discuss your cardiac history with your prescriber.
Můžu pít alkohol?
Alcohol — especially beer — raises serum urate. Reducing alcohol consistently is the lifestyle change with the largest urate impact. Modest amounts may be acceptable; talk to your prescriber.
Jakým potravinám bych se měl vyhnout?
High-purine foods (organ meat, anchovies, sardines, fructose-sweetened drinks) raise urate. Dairy and cherries are protective. Diet alone rarely meets target — it is an adjunct, not a substitute.
How quickly will tophi shrink?
Tophi dissolve over months to years on sustained urate < 0.30 mmol/L. Smaller tophi go first. If tophi do not shrink at 12 months despite confirmed sub-target urate, specialist review is appropriate.
Do I need ongoing blood tests?
Yes. Serum urate every 4–6 weeks during titration; then 6 monthly. LFTs at baseline, 2 months, then periodically. eGFR with the rest of routine bloods.
Co když vynechám dávku?
Take it as soon as you remember the same day. If it is the next day, skip the missed dose — do not double up.
How long do I need to stay on febuxostat?
Indefinitely for established gout. Stopping causes urate to rebound and crystals to redeposit, triggering flares within weeks to months.
Other Bladder & Prostate Medications
- Cystone — herbal urinary / kidney-stone adjunct
- Silofast (silodosin) — alpha-blocker for BPH
- Alfusin (alfuzosin 10 mg ER) — alpha-blocker
- Fosirol 3 g (fosfomycin) — UTI single-dose
- Ketosteril — renal nutrition adjunct
Zdravotní prohlášení. The information on this page is for general educational purposes only and is not a substitute for advice from a qualified clinician. Discuss any new medication or dose change with your doctor or pharmacist, especially if you are pregnant, breastfeeding, have other medical conditions, or take other medicines.
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| Síla | 40 mg, 80 mg |
|---|---|
| Množství | 30 tablet, 60 tablet, 90 tablet |
| Léková forma | Tablet/s |
| Výrobce | Sun Pharma |
| Léčba | Hyperuricaemia / Chronic gout |
| Generická značka | Febuxostat |
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