Iverintas DT-12
Iverintas DT-12 (ivermectin 12 mg dispersible tablet, Intas) — adult dispersible-tablet format for strongyloidiasis, scabies, head lice, and onchocerciasis. Easier swallowing than conventional tablets.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
Quick Answer — What is Iverintas DT-12?
Iverintas DT-12 je perorální ivermectin 12 mg dispersible tablet od Intas. Ivermectin is the WHO-listed first-line agent for strongyloidiasis, scabies, head lice, and onchocerciasis (river blindness). Standard adult dose is 200 µg/kg as a single dose, repeated at day 7–14 for scabies. Take on an empty stomach with water.
The dispersible-tablet (DT) format is designed for paediatric and difficult-swallow use — place the tablet in 5–10 ml of water, allow to disperse, and drink immediately.
📦 Každá objednávka je pokryta naší Zárukou opětovného odeslání — pokud vaše zásilka nedorazí do 20 pracovních dnů, přeposíláme ji.
Proč objednávat z MedsBase
Naše generické léky pocházejí od výrobců certifikovaných WHO-GMP a jsou expedovány po celém světě v diskrétním, nenápadném balení – na vnější straně balíku není uveden název léku. Platby kartou jsou směrovány prostřednictvím regulovaného procesoru (popisky na výpisu zahrnují regulovaného procesora plateb kartou – nikdy “MedsBase” nebo název léku). Přijímáme také kryptoměny a bankovní převody SEPA. Každá objednávka je zajištěna naší politikou přeposlání.
What is Iverintas DT-12?
Iverintas DT-12 is an oral ivermectin product manufactured by Intas, available in 12 mg strengths. Ivermectin is one of the most important drugs in global health — the 2015 Nobel Prize in Physiology or Medicine recognised its discoverers (William Campbell & Satoshi Ōmura) for the contribution it made to controlling river blindness and lymphatic filariasis. Today ivermectin is on the WHO Model List of Essential Medicines and remains first-line for several human parasitic and ectoparasitic diseases.
Mechanism — how ivermectin kills parasites
Ivermectin binds with high affinity to glutamate-gated chloride channels in invertebrate nerve and muscle cells. This opens the channel, hyperpolarises the cell, and paralyses the parasite. Mammalian cells lack glutamate-gated chloride channels (mammalian GABA channels are the closest relative, but ivermectin does not cross an intact blood-brain barrier in normal doses), which is why ivermectin has a wide safety margin in humans.
Ivermectin is highly lipophilic, peaks in plasma at 4–5 hours, and has an elimination half-life of 16–28 hours. Most of the drug is excreted in faeces.
Iverintas DT-12 indications
| Indikace | Dávka | Poznámky |
|---|---|---|
| Strongyloidiasis | 200 µg/kg single dose | Repeat at 14 days in immunocompromised; pre-emptive screening before steroids |
| Scabies | 200 µg/kg, repeat at day 7–14 | Treat all household contacts simultaneously; topical permethrin alternative |
| Head lice | 200 µg/kg, repeat at day 7 | Useful when topical pediculicides have failed |
| Onchocerciasis | 150 µg/kg single dose, every 6–12 months | WHO mass-drug-administration regimen |
| Lymphatic filariasis | 200 µg/kg with albendazole 400 mg | Annual MDA combination therapy |
| Cutaneous larva migrans | 200 µg/kg single dose | Often a one-shot cure |
Iverintas DT-12 dosage — weight-based
Ivermectin is dosed at 200 µg per kg of body weight for most indications (150 µg/kg for onchocerciasis). Convert as follows:
| Body weight | Approx. dose | Tablet equivalent |
|---|---|---|
| 15–25 kg | 3 mg | 1 × 3 mg |
| 26–44 kg | 6 mg | 1 × 6 mg or 2 × 3 mg |
| 45–64 kg | 9 mg | 1 × 6 mg + 1 × 3 mg |
| 65–84 kg | 12 mg | 1 × 12 mg |
| 85–104 kg | 15 mg | 1 × 12 mg + 1 × 3 mg |
| 105–120 kg | 18 mg | 2 × 6 mg + 2 × 3 mg |
Take on an empty stomach with a full glass of water (food increases bioavailability roughly 2.5×, which can change the safety margin in patients with high microfilarial load).
Vedlejší účinky
Ivermectin is generally very well tolerated. The most common side effects are Mazzotti reaction (fever, pruritus, lymphadenopathy, joint pain — caused by dying microfilariae, not the drug itself) in patients with onchocerciasis or lymphatic filariasis. Other reactions:
- Časté: mild dizziness, nausea, transient diarrhoea, headache
- Méně časté: rash, peripheral oedema, abdominal pain
- Vzácné: hypotension, tachycardia, transient transaminase rise
- Very rare: Stevens-Johnson syndrome, encephalopathy (almost exclusively in Loa loa co-infection)
Interakce léků
Ivermectin is metabolised primarily by CYP3A4. Clinically relevant interactions:
- Silné inhibitory CYP3A4 (ritonavir, ketoconazole, itraconazole, clarithromycin) — raise ivermectin levels
- Strong CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) — reduce levels
- Warfarin — case reports of INR changes; monitor
- Other GABA-active drugs — theoretical interaction; watch for sedation in patients on benzodiazepines or sodium oxybate
Kontraindikace
- Hypersensitivity to ivermectin
- Children < 15 kg body weight (limited safety data)
- Loa loa endemic region without pre-screening (severe encephalopathy risk)
- Severe hepatic impairment — use with caution
Skladování
Store Iverintas DT-12 below 30°C in the original blister, away from light and moisture. Keep out of reach of children.
Proč objednávat z MedsBase
Iverintas DT-12 is supplied from a výrobce certifikovaného WHO-GMP, balen diskrétně a expedován po celém světě. Každá objednávka je kryta naším Zárukou opětovného odeslání — nikdy neneseš náklady za ztracenou zásilku.
Často kladené dotazy
Is Iverintas DT-12 the same as ordinary ivermectin?
Yes. Iverintas DT-12 is a brand of ivermectin from Intas. The active ingredient, dose strengths, and pharmacokinetics are the same as any other quality-assured ivermectin product.
Should I take Iverintas DT-12 on an empty stomach?
Yes. Take Iverintas DT-12 with a full glass of water at least 1 hour before food or 2 hours after. A fatty meal can increase plasma levels by roughly 2.5×, which is fine for routine dosing but undesirable in patients with high microfilarial loads.
How quickly does Iverintas DT-12 work for scabies?
Itching and rash improve within several days but take 2–4 weeks to resolve fully because dead mites and eggs remain in the skin. A second 200 µg/kg dose at day 7–14 covers any newly hatched mites that escaped the first dose.
Can I take Iverintas DT-12 with antibiotics?
Most antibiotics are safe to combine. The macrolide clarithromycin is a strong CYP3A4 inhibitor and may raise ivermectin levels — preferable to use azithromycin or doxycycline if a course is also needed.
Does Iverintas DT-12 treat COVID-19?
No. Multiple high-quality randomised trials (TOGETHER, ACTIV-6, COVID-OUT) found no clinical benefit of ivermectin in COVID-19. WHO, FDA, and EMA recommend against off-label use for this indication. Iverintas DT-12 is for parasitic and ectoparasitic disease only.
Is Iverintas DT-12 safe in pregnancy?
Limited human data; reassuring in mass-treatment programmes. Avoid in the first trimester where alternatives exist. Discuss with a clinician for individualised guidance.
Can I drive after taking Iverintas DT-12?
Most patients tolerate ivermectin without sedation. A minority report mild dizziness in the first 24 hours; if so, postpone driving until you feel normal.
How long does Iverintas DT-12 stay in the body?
Plasma half-life is 16–28 hours; the drug is essentially cleared within 5–7 days. The therapeutic effect on scabies persists longer because the drug accumulates in skin.
Does Iverintas DT-12 cure all worms?
Ivermectin is most active against nematodes (roundworms, including strongyloides and onchocerca) and ectoparasites (scabies, head lice). It is NOT first-line for tapeworms (use praziquantel or niclosamide) or whipworm (use albendazole).
Can I crush or split Iverintas DT-12?
Iverintas DT-12 is a dispersible tablet — place it in 5–10 ml of water, let it disperse, and drink. Splitting is unnecessary.
Další antiparazitární léky
- Ivermectol (ivermectin 12 mg)
- Iverheal (ivermektin 3/6/12 mg)
- Ivimec (ivermectin 6/12 mg DT)
- ABD 400 (albendazol 400 mg)
- Bandy-Plus (albendazole + ivermectin)
📚 Zjistit více: Buy Ivermectin for Humans Online (2026): Dosage, Safety & Where to Order
Další možnosti v léčbě roupů
Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 12 mg |
|---|---|
| Množství | 40 Tablet/s, 80 Tablet/s, 120 Tablet/s, 240 Tablet/s, 400 Tablet/s, 800 Tablet/s |
Iverintas DT-12
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Iverintas DT-12
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