Glisen PM
✅ Reguluje hladinu cukru v krvi
✅ Controls diabetes
✅ Zlepšuje citlivost na inzulín
✅ Reduces glucose levels
✅ Zlepšuje kontrolu glykémie
Glisen PM contains Glimepiride, Metformin, and Pioglitazone.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Quick Answer — What is Glisen PM?
Glisen PM je triple-drug fixed-dose combination of glimepiride, pioglitazone and metformin (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg) used for diabetu 2. typu not controlled on dual therapy. It targets hyperglycaemia through three complementary mechanisms: glimepiride stimulates insulin release from the pancreas, pioglitazone reduces insulin resistance in muscle/fat/liver, and metformin reduces liver glucose output. Typical HbA1c reduction: 2.0–2.5 points. Usual dose: one tablet once daily with breakfast. Side-effect profile combines hypoglycaemia risk (from glimepiride), weight gain and oedema (from pioglitazone), and metformin GI upset. Avoid in heart failure, active bladder cancer, eGFR < 30, severe hepatic impairment, and sulfa allergy. This is typically a step before insulin initiation.
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What Is Glisen PM?
Glisen PM is an oral fixed-dose combination tablet containing three active antidiabetic ingredients: glimepiride, pioglitazone and metformin hydrochloride (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg). It is manufactured by WHO-GMP certified manufacturer and supplied in packs of 30, 60, 90 or 180 tablets.
Triple therapy in a single tablet is used when dual therapy (usually metformin + sulfonylurea or metformin + TZD) is not achieving glycaemic targets, and the clinician wants to intensify treatment without starting insulin yet.
How Does Glisen PM Work?
The three components attack hyperglycaemia from three different directions:
- Metformin — reduces hepatic glucose production; improves peripheral insulin sensitivity; no hypoglycaemia on its own.
- Pioglitazon — PPAR-γ agonist; improves insulin sensitivity in muscle, fat and liver; improves lipid profile and fatty liver; no hypoglycaemia on its own.
- Glimepirid — third-generation sulfonylurea; closes beta-cell KATP channels to stimulate insulin release. This is the component that adds hypoglycaemia risk.
Combined HbA1c reduction is typically 2.0–2.5 percentage points compared with dual therapy.
Dávkování a podání
Obvyklá dávka: one tablet once daily, with or just before breakfast. Some prescribers use one tablet twice daily with larger meals if HbA1c is not controlled on once-daily dosing.
- Užívejte s jídlem — improves tolerability and times the sulfonylurea’s insulin release to the post-meal glucose rise.
- Do not skip meals — glimepiride can cause hypoglycaemia on an empty stomach.
- Carry fast-acting carbohydrate.
- Monitor blood glucose, HbA1c, weight, ankle oedema, ALT, and renal function.
- Vitamin B12 check annually (long-term metformin).
Vedlejší účinky
Časté:
- Hypoglykémie — from the glimepiride component; shakiness, sweating, palpitations, hunger, confusion. Treat with 15 g fast-acting carbohydrate.
- Přibývání na váze — 2–4 kg on average (pioglitazone + glimepiride drive gain; metformin slightly offsets).
- Periferní edém — from pioglitazone; most common reason for stopping.
- Metformin GI side effects in first 1–2 weeks (diarrhoea, nausea, metallic taste).
- Mild anaemia (haemodilution from pioglitazone).
Vzácné, ale závažné: severe hypoglycaemia (especially in older adults, renal impairment); heart failure decompensation; bladder cancer (long-term high-dose pioglitazone); macular oedema; bone fracture in women; lactic acidosis (very rare; acute kidney injury or hypoxia).
Interakce s léčivy
- Many drugs raise hypoglycaemia risk: insulin, other antidiabetics, alcohol, trimethoprim/sulfamethoxazole, fluconazole, clarithromycin, ACE inhibitors, high-dose salicylates, non-selective beta-blockers (also mask symptoms).
- Corticosteroids, thiazides, thyroid hormones, phenytoin, rifampicin, atypical antipsychotics, oral contraceptives reduce glucose-lowering effect.
- Gemfibrozil — doubles pioglitazone levels; pioglitazone component limited to 15 mg/day.
- IV contrast — hold Glisen PM pre- and post-procedure if eGFR < 60.
- Kationické léky — raise metformin levels.
Who Should Not Take Glisen PM?
- Srdeční selhání (NYHA III–IV)
- Active bladder cancer or unexplained haematuria
- Těžké renální postižení (eGFR < 30)
- Severe hepatic impairment; ALT > 2.5× ULN
- Diabetická ketoacidóza; diabetes 1. typu
- Alergie na sulfonamidy (sulfa)
- Akutní onemocnění s rizikem tkáňové hypoxie
- Těhotenství, kojení
- Known hypersensitivity to any component
In older adults (> 65): triple therapy containing a sulfonylurea carries a high hypoglycaemia risk. Many clinicians prefer a DPP-4 inhibitor or SGLT-2 inhibitor instead of glimepiride in this group.
Skladování
Store Glisen PM below 30°C in a dry place. Keep out of reach of children.
Často kladené dotazy
When is a triple-drug diabetes tablet like Glisen PM prescribed?
Usually when dual therapy (typically metformin + sulfonylurea, or metformin + TZD) is not achieving HbA1c targets, and the clinician wants to intensify oral therapy before starting insulin. It is also convenient for patients already taking these three medicines separately — one tablet instead of three improves adherence.
Is Glisen PM the same as taking the three drugs separately?
Clinically, yes — same molecules at the same doses. The fixed-dose combination improves adherence and typically costs less, but offers less flexibility if one component needs a dose change.
Will Glisen PM cause low blood sugar?
Yes — it contains glimepiride, a sulfonylurea. Skipping meals, unusual exercise, alcohol without food, and renal impairment all raise hypoglycaemia risk. Always take with food and carry glucose tablets.
How much weight will I gain on Glisen PM?
Typically 2–4 kg over the first year — driven by pioglitazone (fluid and fat redistribution) and glimepiride (anabolic effect of more insulin). Metformin partially offsets this. Diet and exercise are the best counterweights.
Should I switch to insulin instead?
That is a decision for you and your prescriber. Insulin gives more predictable glucose control and is essential once beta-cell reserve is exhausted, but it requires injections and has its own hypoglycaemia and weight-gain profile. Triple oral therapy is often tried first in motivated patients who want to avoid injections.
Where can I buy Glisen PM online?
You can order Glisen PM (Glimepiride 1 mg (or 2 mg) + Pioglitazone 15 mg + Metformin 500 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.
Související léky na diabetes
- Pioglit MF Forte — Pioglitazone + Metformin dual combo
- Glycomet-GP — Metformin + Glimepiride
- Amaryl — Glimepiride monotherapy
- Glycomet SR — Metformin s prodlouženým uvolňováním
- Januvia — Sitagliptin (DPP-4 inhibitor alternative)
- Jardiance — Empagliflozin (alternativa SGLT-2)
- Prohlédnout všechny léky na diabetes
Související alternativy
Další produkty v Chronická onemocnění které zákazníci také prohlížejí:
Více možností v léčbě diabetu
Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 1+15+500 mg, 2+15+500 mg |
|---|---|
| Množství | 30 tablet/ks, 60 tablet/ks, 90 tablet/ks, 180 tablet/ks |
Glisen PM
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Glisen PM
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