Rychlá odpověď
Lenalid — Lenalidomide 5/10/25 mg (Natco Pharma). Immunomodulatory drug (IMiD) for multiple myeloma (newly diagnosed and relapsed/refractory), 5q-myelodysplastic syndrome, and mantle cell lymphoma. Modern IMiD with greater potency and fewer neuropathy/sedation side effects than thalidomide.
Co získáte s MedsBase:
- výrobce certifikovaného WHO-GMP
- Diskrétní balení v obyčejné obálce
- Dodání po celém světě
- Hodnoceno více než 1 400 zákazníky (číst recenze)
📦 Záruka opětovného zaslání: pokud vaše objednávka nedorazí do 20 pracovních dnů od odeslání, zašleme ji znovu bez dalších nákladů. Přečíst podmínky.
Proč objednávat z MedsBase
Lenalid ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
⚠️ Specializovaná onkologická léčba pod dohledem lékaře — tento lék je zahajován, monitorován a ukončován onkologem nebo hematologem. Dávkování závisí na typu nádoru, stadiu, tělesném povrchu, funkci orgánů a současné terapii. Samoléčba není vhodná; níže uvedené informace jsou vzdělávací a podporují informované rozhovory s vaším specialistou.
All IMiDs are severely teratogenic (thalidomide most notoriously — phocomelia). Mandatory pregnancy-prevention programme (REMS/iCare equivalent): pregnancy testing before, during, and after; two effective contraceptive methods; counselling for both partners; no blood donation during therapy or for 4 weeks after. Even one dose during pregnancy can cause severe malformations.
IMiDs carry significantly elevated risk of deep vein thrombosis and pulmonary embolism, especially in combination with corticosteroids or doxorubicin. Mandatory thromboprophylaxis: low-dose aspirin (low-risk), or LMWH/warfarin/DOAC (higher-risk patients). Specialist-determined.
All IMiDs cause myelosuppression — neutropenia, thrombocytopenia, anaemia. Weekly FBC during initiation; monthly maintenance. Renal dose adjustment (lenalidomide especially — significant renal accumulation).
Často kladené dotazy
Kdy se to používá?
Immunomodulatory drug (IMiD) for multiple myeloma (newly diagnosed and relapsed/refractory), 5q-myelodysplastic syndrome, and mantle cell lymphoma. Modern IMiD with greater potency and fewer neuropathy/sedation side effects than thalidomide.
Jak se užívá?
Once daily, typically in cycles (e.g., 21 days on, 7 days off for lenalidomide). Specific dose and schedule are myeloma-protocol-specific (Rd, RVd, KRd, etc.). Specialist-determined by tumour response and tolerability.
Pregnancy prevention?
Mandatory programme: monthly pregnancy tests, two effective contraceptive methods, partner contraception, counselling. Even one dose during pregnancy causes severe malformations. No blood donation during therapy or for 4 weeks after stopping.
Časté nežádoucí účinky?
IMiD class: VTE, fatigue, rash, GI (constipation, diarrhoea), myelosuppression. Lenalidomide: less neuropathy than thalidomide. Pomalidomide: often better tolerated than thalidomide; renal-friendly. Thalidomide: peripheral neuropathy, sedation.
Interakce léků?
Anticoagulants — adjust based on VTE prophylaxis strategy. Digoxin levels may rise. Erythropoietin agents + IMiD — increased thrombosis risk; use only with mandatory thromboprophylaxis.
Monitorování funkce ledvin?
Lenalidomide: dose-adjust by CrCl (significant renal accumulation). Pomalidomide: less renal effect but still monitor. Thalidomide: renally cleared metabolite — monitor renal function.
Co když vynechám dávku?
Take when you remember if <12 hours late; otherwise skip and resume — do not double up. Notify oncology team if multiple doses missed.
Očkování?
Inactivated vaccines OK; live vaccines contraindicated during IMiD therapy. Optimise vaccinations before starting if possible.
Dlouhodobé komplikace?
IMiD therapy: secondary primary malignancies (especially with extended use), cumulative VTE risk, neuropathy (thalidomide especially).
Kdy se léčba ukončuje?
Specialist-determined: response duration, toxicity, planned treatment break, transition to maintenance therapy. IMiD maintenance therapy is now standard in myeloma — typically lenalidomide post-autologous stem cell transplant continued for 2-3 years or until intolerance.
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