Maxiliv Injection

📦 Každá objednávka je pokryta naší Zárukou opětovného odeslání — pokud vaše zásilka nedorazí do 20 pracovních dnů, přeposíláme ji.

Proč objednávat z MedsBase

Naše generické léky pocházejí od výrobců certifikovaných WHO-GMP a jsou expedovány po celém světě v diskrétním, nenápadném balení – na vnější straně balíku není uveden název léku. Platby kartou jsou směrovány prostřednictvím regulovaného procesoru (popisky na výpisu zahrnují regulovaného procesora plateb kartou – nikdy “MedsBase” nebo název léku). Přijímáme také kryptoměny a bankovní převody SEPA. Každá objednávka je zajištěna naší politikou přeposlání.

Proč objednávat z MedsBase

Maxiliv Injection is supplied from a výrobce certifikovaného WHO-GMP. Every order ships discreetly worldwide and is covered by our Zárukou opětovného odeslání — if it does not arrive within 20 business days, we reship at no cost. IV glutathione is used as supportive therapy in oncology and hepatology — not as a cosmetic intervention. Clinical doses, frequencies, and administration protocols are determined by the treating physician.

Mechanism

Glutathione is a thiol tripeptide that exists in reduced (GSH) and oxidised (GSSG) forms; the reduced form donates electrons to neutralise hydrogen peroxide and lipid peroxides via glutathione peroxidase, and conjugates reactive electrophiles via glutathione-S-transferase. Cellular glutathione is depleted by oxidative stress, paracetamol overdose, alcohol, ageing, and several disease states. IV glutathione transiently raises circulating levels; cellular uptake of intact GSH is limited, but the molecule is hydrolysed and the constituent amino acids (especially cysteine, the rate-limiting precursor) support intracellular re-synthesis.

Clinical indications

• Cisplatin- and oxaliplatin-induced peripheral neuropathy (Schmitt 2009 trial — preserved sensory nerve function on serial nerve-conduction studies)
• Oxidative liver stress in chronic hepatitis, fatty liver, post-anaesthetic, post-chemotherapy
• Acute paracetamol toxicity (N-acetylcysteine is the standard antidote that replenishes intracellular GSH; IV GSH is supplementary)
• Some Parkinson’s disease research protocols (off-label, low evidence)
• Idiopathic pulmonary fibrosis adjunct (low evidence)

Doses (clinician-determined)

Cisplatin-induced neuropathy: 1.5–2.4 g IV before each chemotherapy cycle. Hepatic support: 600 mg–1.2 g once daily or every other day. Always slow IV push or short infusion in compatible diluent (typically 5 percent dextrose or normal saline; check compatibility per local protocol).

Vedlejší účinky

• Injection-site reactions, mild venous irritation
• Sulphurous taste / smell during infusion
• Hypersensitivity (rare; thiol allergy, asthma triggers)
• Stevens-Johnson syndrome / TEN (rare but reported, particularly with frequent unsupervised cosmetic dosing)
• Thyroid dysfunction with chronic high-dose use (FDA cosmetic-use warning)
• Renal impairment (rare)

Cautions

• Severe asthma (sulphite/thiol exacerbation risk)
• Active malignancy — specialist oncology decision (concern that antioxidant therapy could blunt chemo cytotoxicity offset by neuroprotection benefit)
• Pregnancy and breastfeeding — insufficient data, avoid unless clinical benefit is clear
• Renal impairment — reduce dose

Často kladené dotazy

Can I have IV glutathione for skin-whitening?

No — this is not a recognised medical indication. The FDA has issued specific warnings against unsupervised IV glutathione for cosmetic use due to serious adverse-event reports.

Does it really protect against chemo-induced neuropathy?

Schmitt 2009 (Italian Multicentre Cooperative Group) showed reduced sensory neuropathy on cisplatin in colorectal cancer patients pre-treated with IV glutathione. Several subsequent trials have shown variable effects. It remains an option in oncology supportive care but is not universally adopted.

How is it administered?

By a healthcare professional, intravenously, after reconstitution with a compatible diluent. Self-administration is unsafe and not endorsed.

Are there oral alternatives?

Liposomal oral glutathione has modest absorption. N-acetylcysteine (NAC) 600–1200 mg/day is a more bioavailable cysteine precursor and is the standard oral approach to raising intracellular glutathione.

Is it safe in pregnancy?

Insufficient data — avoid unless the clinical situation strongly justifies it. NAC has a longer pregnancy safety record.

Can I take it with chemotherapy?

Only under oncology supervision. The interaction between antioxidant supplementation and chemotherapy efficacy is debated; clinical decisions need to be made within the multidisciplinary team.

Why does it smell of sulphur?

Glutathione contains a sulfhydryl (-SH) group. The smell during infusion is harmless and dissipates within minutes.

How often should I have it?

Determined by the treating clinician. Frequent dosing (more than once weekly) is not supported by clinical evidence and increases risk of adverse reactions.

Skladování

Below 25°C, protect from light. Discard reconstituted solution if not used within the local protocol’s stability window (typically 2–4 hours).

Co když vynechám dávku?

Discuss with the treating clinician. Do not self-administer or arrange unsupervised infusions.

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