Lasix Injection
Lasix Injection is Sanofi’s furosemide 40 mg / 4 mL IV ampoules — the reference intravenous loop diuretic. For acute pulmonary oedema, decompensated heart failure, cirrhotic ascites requiring rapid intervention, oliguric AKI, hypercalcaemia of malignancy. IV onset 5 minutes; max push rate 4 mg/min (faster raises ototoxicity risk); 2-hour brisk diuresis. Supervised clinical use only — not a self-administered product.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Lasix Injection?
Lasix Injection is injectable furosemide (frusemide) 40 mg / 4 mL ampoule from Sanofi — a loop diuretic for intravenous or intramuscular use. Used when oral loop diuretics are inadequate or impossible — acute pulmonary oedema, decompensated heart failure, cirrhotic ascites needing rapid intervention, hypercalcaemia of malignancy, oliguric AKI management, and acute management of severe fluid overload. Typical adult dose: 20-80 mg slow IV bolus (4 mg/min max); titrated to response. May repeat every 2-4 hours or use continuous infusion 5-40 mg/hour in severe HF. IV use is a supervised clinical procedure — not a self-administered product. Requires clinical monitoring for ototoxicity (rapid IV push), severe hypokalaemia, hypovolaemia, and pre-renal AKI. Absolutely contraindicated in anuria, severe electrolyte disturbance, hepatic encephalopathy, sulfonamide hypersensitivity.
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What Is Lasix Injection?
Lasix Injection is injectable furosemide (frusemide in UK/India nomenclature) supplied as 40 mg / 4 mL ampoule glass ampoules from Sanofi, in 10-60 ampoules. For intravenous or intramuscular administration by a qualified clinician.
Furosemide is the reference loop diuretic, introduced by Hoechst in 1964 as Lasix — “Lasts Six hours”. The injection is used when oral administration is impossible (vomiting, nil-by-mouth status, gut oedema impairing absorption) or when rapid onset is essential (acute pulmonary oedema, hypertensive emergency with volume overload).
How Injectable Furosemide Works
Furosemide blocks NKCC2 (Na-K-2Cl cotransporter) in the thick ascending limb of the loop of Henle. Key features of the IV route:
- 5-minute onset after IV bolus (vs 30-60 min orally); 1-2 hour peak; 2-hour duration of brisk diuresis, waning over 6 hours
- Direct venodilation within minutes of IV administration — contributes to symptomatic relief in acute pulmonary oedema before the diuresis arrives
- Up to 25% of filtered sodium excreted — the largest natriuretic response of any diuretic class
- Bioavailability issue bypassed — oral furosemide bioavailability is 10-90% and varies with gut oedema; IV bypasses this entirely
Approved and Evidence-Based Uses
- Acute pulmonary oedema — cornerstone therapy with oxygen, nitrates, and positive-pressure ventilation
- Acute decompensated heart failure
- Cirrhotic ascites needing rapid volume reduction (inpatient; combined with spironolactone)
- Oliguric acute kidney injury — to convert oliguric to polyuric AKI (does NOT improve survival; facilitates fluid management only)
- Hypercalcaemia of malignancy — after adequate saline rehydration
- Hypertensive emergencies with volume overload
- Nephrotic syndrome with severe oedema
Dosage
Standard adult IV bolus: 20-80 mg slow IV push, maximum infusion rate 4 mg/min (faster push raises ototoxicity risk). Onset 5 minutes; repeat every 2-4 hours if needed.
Severe HF / ITU setting: continuous IV infusion 5-40 mg/hour is often preferred to repeated boluses — produces smoother natriuresis with less ototoxicity than very high bolus doses. Patients with CKD and HF may require 100-250 mg/hour under specialist supervision.
Intramuscular: 20-40 mg where IV access is impossible; less commonly used.
Monitoring during IV therapy:
- Continuous BP monitoring (risk of rapid over-diuresis and hypotension)
- Serial electrolytes — potassium, magnesium, sodium, creatinine — at least every 6-12 hours in acute HF
- Urine output and daily weight
- Watch for ototoxicity especially with concurrent aminoglycosides or renal failure
- Convert to oral furosemide or torasemide as soon as clinically feasible
Side Effects
- Hypovolaemia and pre-renal AKI with over-diuresis
- Hypokalaemia, hyponatraemia, hypomagnesaemia, hypocalcaemia
- Ototoxicity — transient tinnitus, reversible hearing loss, rarely permanent. Risk factors: rapid IV push >4 mg/min, cumulative high doses, concurrent aminoglycosides or cisplatin, renal failure
- Hyperuricaemia, gout flare
- Mild hyperglycaemia
- Photosensitivity, rash
- Interstitial nephritis (rare)
- Thrombocytopenia, leucopenia (rare)
Contraindications
- Anuria (unless urine flow can be established)
- Sulfonamide hypersensitivity
- Severe hepatic impairment with encephalopathy (electrolyte shifts precipitate coma)
- Severe dehydration and pre-renal azotaemia
- Symptomatic severe hyponatraemia (<125 mmol/L) or hypokalaemia (<3.0)
- Digitalis toxicity (until hypokalaemia corrected)
Drug Interactions
- Aminoglycoside antibiotics (gentamicin, amikacin) — additive ototoxicity and nephrotoxicity. Avoid combination at high doses.
- Lithium — reduced lithium clearance; precipitate toxicity. Avoid combination.
- NSAIDs — blunt diuretic effect; triple-whammy AKI with ACEi/ARB.
- ACE inhibitors, ARBs — combination is standard in HF; monitor renal function and BP carefully.
- Digoxin — hypokalaemia potentiates toxicity. Monitor potassium.
- Corticosteroids, amphotericin B, stimulant laxatives — additive hypokalaemia.
- Cisplatin — additive ototoxicity.
- Metformin — caution; lactic acidosis risk if AKI develops.
Storage
Store Lasix Injection below 25°C, protected from light. Do not freeze. Discard if particulate matter or discolouration is seen. Keep out of reach of children.
Frequently Asked Questions
Can I self-administer Lasix Injection?
No — intravenous furosemide is a supervised clinical procedure. Rapid IV push can cause ototoxicity and severe hypotension. Home use, if clinically appropriate, is typically via community IV nursing or hospital-supported ambulatory diuresis programmes. For home self-care of chronic oedema, oral furosemide or torasemide is preferred.
How fast should Lasix Injection be given?
Slow IV push with a maximum rate of 4 mg/min — so a 40 mg dose should take at least 10 minutes. Faster push substantially raises ototoxicity risk. In severe HF, continuous infusion (5-40 mg/hour) is often preferred to large boluses.
What is the difference between oral and IV furosemide dosing?
Oral furosemide bioavailability averages 50% but varies 10-90% between patients and across conditions (gut oedema reduces absorption). A rough equivalence: 40 mg oral ≈ 20 mg IV. In patients with HF and suspected gut oedema, switching from oral to IV often “unlocks” a diuretic response that oral dosing could not achieve.
When should Lasix Injection be avoided?
Avoid in anuria (no response), severe dehydration, hepatic encephalopathy (precipitates coma), severe electrolyte disturbance, and sulfonamide hypersensitivity. Use with caution in concurrent aminoglycoside or cisplatin therapy (additive ototoxicity).
Where can I buy Lasix Injection online?
You can buy Lasix Injection (furosemide 40 mg / 4 mL ampoule, 10-60 ampoules) from MedsBase with discreet packaging and worldwide shipping.
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Lasix Injection
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