Reglan
Reglan (Metoclopramide 10 mg) — central + peripheral D2 antagonist prokinetic and antiemetic. Carries FDA black-box for tardive dyskinesia (12-week max). For nausea, vomiting, gastroparesis, migraine-associated nausea. Worldwide shipping from MedsBase.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Reglan?
Reglan is metoclopramide 10 mg — a centrally and peripherally acting dopamine D2 receptor antagonist used as an antiemetic and prokinetic. It accelerates gastric emptying, increases LES tone, and blocks the chemoreceptor trigger zone. Indications include nausea/vomiting (post-operative, chemotherapy adjunct, migraine-associated), gastroparesis, and prevention of aspiration. Standard dose: 10 mg three times daily before meals, for a maximum of 5 days (FDA) or 12 weeks (EMA gastroparesis exception). WHO-GMP certified manufacturer.
📦 Every order is covered by our Reshipment Assurance Policy — if your parcel does not arrive within 20 business days, we reship it.
Why order from MedsBase
Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging — no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor — never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.
Why order from MedsBase
Reglan is supplied from a WHO-GMP certified manufacturer. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.
Mechanism of action
Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.
Indications
- Nausea and vomiting (chemotherapy-induced, post-operative, migraine-associated)
- Diabetic and idiopathic gastroparesis (12-week max under EMA)
- Aspiration prevention pre-anaesthesia (rapid-sequence induction adjunct)
- Adjunct in radiology to speed barium transit
- Off-label: galactagogue
Dose
Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.
Side effects
- Common: drowsiness, restlessness, fatigue, diarrhoea
- Extrapyramidal: acute dystonia, akathisia, parkinsonism, tardive dyskinesia (BLACK-BOX)
- Hyperprolactinaemia: galactorrhoea, gynaecomastia, menstrual disturbance
- Rare: neuroleptic malignant syndrome, seizures, methaemoglobinaemia (G6PD-deficient infants)
- Cardiac: bradycardia and hypotension after rapid IV push
Drug interactions
- Anticholinergics, opioids: oppose the prokinetic effect.
- Other dopamine antagonists (haloperidol, risperidone, prochlorperazine): additive extrapyramidal risk — avoid stacking.
- MAO inhibitors: hypertensive crisis — avoid.
- SSRIs, SNRIs: serotonin syndrome (rare).
- Levodopa: each blocks the other's effect — do not co-prescribe.
- Digoxin: gastric-emptying acceleration may reduce digoxin absorption.
Frequently Asked Questions
How is Reglan different from domperidone?
Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.
What does the FDA black-box mean for me?
Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.
Can I take it for travel sickness?
There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.
Is it safe in pregnancy?
Category B in the US. Used in pregnancy for nausea/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.
Can I drive on this?
Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.
What if I develop a stiff neck or strange jaw movements?
Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.
Why do I have leaky breasts on this medication?
Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.
Can it interact with my Parkinson’s drugs?
Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.
Storage
Below 25°C in a dry place. Keep out of reach of children.
What if I miss a dose?
Take it before the next meal, then continue. Do not double up.
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Ranked by recent MedsBase order volume — what other customers in this category are picking.
| Strength | 10 mg |
|---|---|
| Quantity | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 180 Tablet |
Reglan
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