Mesacol

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Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.

What Is Mesacol?

Mesacol is an oral aminosalicylate (5-ASA) medicine containing mesalamine (400 mg or 800 mg), supplied as delayed-release Eudragit-S enteric-coated tablets. Manufactured by Sun Pharma in packs of 30, 60, 90 or 180 tablets. Mesalamine is the active metabolite of older sulfasalazine — without the sulfapyridine moiety that caused most of sulfasalazine’s systemic side effects.

Mesalamine has been a first-line therapy for mild-to-moderate ulcerative colitis since the 1980s and is recommended as induction and maintenance therapy by ACG, ECCO, and BSG guidelines. The original mesalamine brand Asacol was approved in 1987; today there are several delivery systems (Eudragit-coated, ethylcellulose microgranule, MMX multi-matrix) each designed to release mesalamine at a different point in the gastrointestinal tract.

What Is Mesacol Used For?

• Induction of remission in active mild-to-moderate ulcerative colitis
• Maintenance of remission in ulcerative colitis
• Some mild Crohn’s colitis cases (off-label in many countries; evidence is weaker than for UC)
• Ulcerative proctitis and left-sided colitis (often combined with rectal mesalamine formulations)

Mesacol is niet a treatment for:

• Irritable bowel syndrome (IBS) — a functional disorder without mucosal inflammation. IBS is treated with antispasmodics (mebeverine), gut-selective antibiotics for IBS-D (rifaximin), dietary intervention (low-FODMAP), and central modulators (low-dose TCAs/SSRIs)
• Infectious colitis (e.g. C. difficile, Salmonella, Shigella)
• Microscopic colitis — budesonide is preferred

How Does Mesacol Work?

Mesalamine is a topical intestinal anti-inflammatory. Its exact mechanism is multifactorial, involving several anti-inflammatory pathways in the colonic mucosa:

• Inhibition of cyclooxygenase and lipoxygenase pathways — reduces local prostaglandin and leukotriene synthesis
• Scavenging of reactive oxygen species produced by neutrophils in inflamed mucosa
• Inhibition of NF-κB — dampens the transcription of pro-inflammatory cytokines
• PPAR-γ agonism in colonocytes — contributes to resolution of inflammation
• Reduces neutrophil chemotaxis into the colonic mucosa

Because mesalamine’s target is the colonic mucosa, delivery is critical. The delayed-release Eudragit-S enteric-coated tablets of Mesacol is designed to release active drug in the colon rather than being absorbed prematurely in the small intestine. Eudragit-S coating dissolves at pH ≥ 7 (terminal ileum/colon); Eudragit-L at pH ≥ 6 (duodenum/jejunum); ethylcellulose microgranules release continuously; MMX uses a lipophilic/hydrophilic matrix for controlled colonic release.

Dosering en toediening

Induction of remission in mild-to-moderate UC: 2.4–4.8 g/day in divided doses. Maintenance of remission: 1.6–2.4 g/day.

• Take with or shortly after food (reduces GI upset and may improve colonic delivery).
• Swallow tablets whole — do not crush or chew Eudragit-coated or MMX tablets; the coating is the delivery system.
• Seeing intact tablet shells in stool can happen with some formulations (particularly MMX “ghost” tablets) — this is expected and does not mean the drug failed to absorb.
• Maintain good hydration — supports renal clearance.
• Adherence is critical. Mesalamine is a daily maintenance drug; missing doses is the single biggest predictor of UC relapse.
• Miss a dose — take it as soon as you remember, unless close to the next dose; do not double up.

Bijwerkingen

Mesalamine is usually well-tolerated compared with sulfasalazine and immunomodulators.

Vaak voorkomend:

• Hoofdpijn
• Nausea, abdominal pain, flatulence
• Diarrhoea (ironic for a colitis drug, but real — 1–3% of users)
• Rash, itching
• Occasional hair loss (mild, reversible)

Zeldzaam maar belangrijk:

• Nierfunctiestoornis — interstitial nephritis is a rare but documented class effect. Check serum creatinine at baseline, at 3 months, then annually. Discontinue if eGFR drops by > 25%.
• Acute mesalamine intolerance syndrome — paradoxical worsening of colitis symptoms shortly after starting. Very rare; stop the drug.
• Blood dyscrasias — rare neutropenia, thrombocytopenia; check FBC if unexplained infection or bruising.
• Pancreatitis — zeer zeldzaam
• Myocarditis / pericarditis — very rare; new chest pain warrants evaluation
• Hepatitis — very rare, usually reversible

Geneesmiddelinteracties

• Azathioprine / mercaptopurine / thiopurines — mesalamine inhibits TPMT and can raise thiopurine levels; monitor FBC more closely when the combination is used.
• NSAID's — additive renal risk; avoid chronic use.
• PPIs and antacids — may alter gastric pH and disrupt pH-dependent coating dissolution; separate Eudragit-coated mesalamine from high-dose PPIs by 4 hours if possible, or choose a pH-independent formulation.
• Warfarine — possible increased anticoagulant effect; monitor INR when starting.
• Methotrexaat — additive myelosuppression risk.
• Live vaccines — no meaningful interaction with mesalamine alone (unlike with sulfasalazine or biologics).

Who Should Not Take Mesacol?

• Known hypersensitivity to salicylates (including aspirin) or mesalamine
• Severe renal impairment (eGFR < 30 mL/min)
• Ernstige leverfunctiestoornis
• Children below the label age cutoff (differs by formulation)
• Active peptic ulcer disease
• Pregnancy and breastfeeding — mesalamine has a reassuring safety record and is commonly continued through pregnancy when UC control requires it; discuss with your gastroenterologist and obstetrician

Opslag

Store Mesacol below 25°C in a dry place, in the original blister. Keep out of reach of children. Protect from light and moisture.

Veelgestelde vragen

Is mesalamine the same as mesalazine or 5-ASA?

Yes — all three names refer to the same molecule (5-aminosalicylic acid). Mesalamine is the US adopted name (USAN); mesalazine is the international non-proprietary name (INN); 5-ASA is the chemical abbreviation. Different brands and regions label it differently.

Can I take Mesacol for IBS or general bloating?

No — mesalamine does not treat IBS. IBS is a functional disorder; there is no mucosal inflammation for mesalamine to work on. For IBS, first-line treatments are dietary changes (low-FODMAP diet, fibre modification), antispasmodics like mebeverine (Colospa) or hyoscine, and — for IBS-D specifically — short courses of rifaximin (Rifagut). Central modulators (low-dose amitriptyline) are used for refractory IBS pain.

How long until Mesacol works?

Symptom improvement typically begins within 1–2 weeks; full remission in 4–8 weeks at induction doses. Stool frequency and urgency usually improve first, followed by abdominal pain and finally mucosal healing (visible on colonoscopy at 8–12 weeks).

Do I need to take Mesacol forever?

Most patients with ulcerative colitis need long-term maintenance mesalamine to stay in remission — typically at least 1.6–2.4 g/day. Stopping after remission is achieved leads to relapse within 6–12 months in most studies. Mesalamine is safe for decades of use when renal function is monitored.

Why am I seeing intact tablet shells in my stool?

Several mesalamine formulations (particularly MMX “ghost” tablets) pass through largely intact in the stool. This is verwacht and the drug has been released inside the colon as designed. If you see the tablet unchanged with no coating damage, check your technique; otherwise no action is needed.

Can I take aspirin or NSAIDs with Mesacol?

Short paracetamol (acetaminophen) is preferred for pain in UC. Chronic NSAID use can both precipitate UC flares en increase the renal risk of mesalamine — avoid where possible. Occasional use is usually tolerated.

Where can I buy Mesacol online?

You can order Mesacol (400 mg or 800 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.

Related IBS & IBD Medications

• Mesacol — Mesalamine 400/800 mg (Sun Pharma)
• Asacol — Mesalamine 400 mg (Win-Medicare)
• Mesacol OD — Mesalamine 1.2 g once-daily (MMX)
• Sazo — Sulfasalazine 500 mg
• Salazar — Sulfasalazine
• Colospa — Mebeverine 135 mg (IBS antispasmodic)
• Rifagut — Rifaximin (gut-selective antibiotic)
• Browse all IBS & IBD Medications

Waarom bestellen bij MedsBase

Mesacol is supplied from a WHO-GMP gecertificeerde fabrikant. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Mesalamine 400 mg delayed-release is the WHO-recommended first-line for ulcerative colitis induction and maintenance — topical action with minimal systemic exposure.

Other Gastro Health Medications

• Budez CR — Budesonide CR (terminal-ileal Crohn’s)
• Saaz — Sulfasalazine 500 mg
• Pentasa Suppositories — Mesalazine 1 g
• Rifagut — Rifaximin (gut-selective antibiotic)
• Colospa — Mebeverine (IBS antispasmodic)
• Browse all Gastro Health Medications

More options in Irritable Bowel Syndrome (IBS) Treatment

Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.

Colospa

US$39.00 – US$152.00Zakres cen: US$39.00 do US$152.00

Mesacol OD

US$69.00 – US$260.00Zakres cen: US$69.00 do US$260.00

Salazar

US$42.00 – US$162.00Zakres cen: US$42.00 do US$162.00

Sazo

US$42.00 – US$163.00Zakres cen: US$42.00 do US$163.00