Rcifax
Rcifax (Rifaximin 400 mg or 550 mg) — non-absorbable rifamycin for traveller’s diarrhoea, hepatic encephalopathy prevention, and IBS-D. Less than 0.4 percent systemic absorption. WHO-GMP certified manufacturer. Worldwide shipping from MedsBase.
✓ Lääketieteellinen tarkistus Morgan Ellis — Farmasian tutkija · 8 vuoden kokemus · Viimeisin arvio: toukokuu 2026
⚡ Quick Answer — What is Rcifax?
Rcifax on rifaximin 400 mg or 550 mg — a non-absorbable rifamycin antibiotic that acts almost entirely within the gut lumen. Three validated indications: traveller’s diarrhoea (non-invasive E. coli), prevention of overt hepatic encephalopathy in cirrhosis, and IBS-D (diarrhoea-predominant irritable bowel). Less than 0.4 percent of an oral dose is absorbed systemically, so off-target side effects, drug interactions, and resistance pressure on commensal bacteria are minimal. WHO-GMP certified manufacturer.
📦 Jokainen tilaus on katettuna meidän Reshipment Assurance Policy -politiikkamme piiriin — jos lähetyksesi ei saavu 20 arkipäivässä, lähetämme uuden.
Miksi tilata MedsBasesta
Geneeriset lääkkeemme on hankittu WHO-GMP sertifioiduilta valmistajilta ja toimitettu maailmanlaajuisesti hienotunteisessa, neutraalissa pakkauksessa — lääkkeen nimeä ei ole pakkauksen ulkopuolella. Korttimaksut käsitellään säädeltyjen maksunvälittäjien kautta (tilisiirtojen kuvaukset sisältävät säädellyn korttimaksun käsittelijän — ei koskaan “MedsBase” tai lääkkeen nimeä). Kryptovaluutat ja SEPA-pankkisiirrot hyväksytään myös. Jokainen tilaus on turvattu meidän Reshipment Assurance Policy -takuuohjelmalla.
Miksi tilata MedsBasesta
Rcifax is supplied from a WHO-GMP sertifioitu valmistaja. Jokainen tilaus toimitetaan hienostuneesti maailmanlaajuisesti ja kuuluu Reshipment Assurance Policy -politiikkamme piiriin — if it does not arrive within 20 business days, we reship at no cost. Rifaximin is endorsed by AASLD 2021 for hepatic encephalopathy prevention and by ACG 2021 for traveller’s diarrhoea and IBS-D — one of the few antibiotics with strong evidence in functional GI disorders.
Toimintamekanismi
Rifaximin binds the β-subunit of bacterial DNA-dependent RNA polymerase (rpoB), inhibiting bacterial RNA synthesis. Spectrum covers Gram-positive and Gram-negative aerobes and anaerobes including E. coli, Shigella, Salmonella, Campylobacter, and many enteric anaerobes. Because absorption is < 0.4 percent of the oral dose, the drug acts effectively only on intra-luminal organisms.
Indications & doses
| Käyttöaihe | Annos | Kesto |
|---|---|---|
| Traveller’s diarrhoea (non-invasive) | 200–400 mg three times daily | 3 päivää |
| Hepatic encephalopathy — prevention | 550 mg twice daily | Long-term, with lactulose |
| IBS-D | 550 mg three times daily | 14 days; can be re-dosed up to 2 more times if symptoms recur |
| Small-intestinal bacterial overgrowth (SIBO) | 550 mg three times daily | 14 days (off-label) |
| Diverticulitis (mild) | 400 mg kaksi kertaa päivässä | 7 days (off-label, with diet) |
When it is NOT the right drug
- Invasive enteric infection (fever, bloody stool, severe systemic illness) — needs ciprofloxacin or azithromycin systemically.
- Pseudomembranous colitis (C. difficile) — oral vancomycin or fidaxomicin is first-line; rifaximin has limited evidence as a relapse-prevention adjunct.
- Suspected typhoid — needs systemic antibiotic.
- Suspected appendicitis / cholangitis / pyelonephritis — needs systemic.
Sivuvaikutukset
- Gastrointestinal: nausea, abdominal pain, flatulence (mostly mild)
- Päänsärky, huimaus
- Peripheral oedema (with HE-prevention long courses)
- C. difficile-associated diarrhoea (rare; the gut-selective profile reduces but does not eliminate this risk)
- Hypersensitivity reactions (rare): rash, urticaria, anaphylaxis
- Cross-reactivity with rifampicin/rifabutin in patients with rifamycin allergy
Lääkevuorovaikutukset
Rifaximin’s very low systemic absorption means clinically significant interactions are unusual. However:
- P-gp inhibitors (cyclosporin) raise the small absorbed fraction.
- Warfarin: isolated reports of INR change — check INR if used concurrently.
- Yhdistetty ehkäisypilleri: oral contraceptive efficacy is theoretically reduced if rifaximin causes severe diarrhoea (transit time effect).
Usein Kysytyt Kysymykset
How quickly does it work in traveller’s diarrhoea?
Symptom improvement is usually within 24–48 hours. The 3-day course is sufficient for non-invasive E. coli, the most common cause. If symptoms are severe (fever, bloody stool) or do not improve in 48 hours, change to systemic antibiotic.
Does it cure IBS?
No. Rifaximin reduces IBS-D symptoms in about 40 percent of patients; benefit lasts 10–12 weeks. It can be repeated if symptoms recur. It is not a cure but a useful symptomatic intervention.
Why do I need lactulose with it for hepatic encephalopathy?
Lactulose acidifies the colon and ion-traps ammonia. Rifaximin reduces ammonia-producing bacteria. The two work synergistically; combination therapy reduces HE recurrence by ~60 percent versus lactulose alone.
Voinko juoda alkoholia hoidon aikana?
There is no disulfiram-like interaction. However, traveller’s diarrhoea recovery and HE prevention both benefit from minimal alcohol intake.
Onko se turvallinen raskauden aikana?
Category C. Used in pregnancy when the indication justifies it (HE in pregnant cirrhotic) under specialist advice. Discuss with obstetric prescriber.
How is it different from rifampicin?
Same drug-class binding target but rifampicin is highly absorbed (oral bioavailability ~90 percent) and used systemically for tuberculosis, leprosy, and meningococcal prophylaxis — with significant CYP3A4/2C19 induction and CYP-driven interactions. Rifaximin is gut-restricted with negligible systemic effect.
Will it disrupt my normal gut bacteria?
Yes, but transiently. The gut microbiome typically recovers within 2–4 weeks. Probiotics during and after the course may shorten recovery (modest evidence).
Is resistance a concern?
Rifaximin resistance can develop in enteric bacteria with repeated courses but the impact on systemic rifamycin use (rifampicin for TB, rifabutin for HIV) is limited because rifaximin is not used systemically. Still, avoid casual repeat courses.
Säilytys
Below 30°C, dry place. Keep blister sealed until use.
Mitä teen, jos unohdan ottaa annoksen?
Take it as soon as you remember unless close to the next dose. Do not double up. Try to keep the schedule consistent.
Muut ruoansulatuskanavan lääkkeet
- Rifagut — Rifaximin (alternate brand)
- Ciplox — Ciprofloxacin (systemic option for invasive enteric infection)
- Synclar — Klaritromysiini (H. pylori)
- Cendox — Doksysykliini
- Colospa — Mebeverine (IBS-antispasmodinen)
- Selaa kaikki ruoansulatuskanavan lääkkeet
More options in Gastro Health
Luokiteltu MedsBase-tilausmäärän mukaan — mitä muut asiakkaat tässä kategoriassa valitsevat.
| Vahvuus | 400 mg, 550 mg |
|---|---|
| Määrä | 30 tablettia, 60 tablettia, 90 tablettia, 180 tablettia |
Rcifax
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Rcifax
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