ABD 400 (Albendazole)
ABD 400 (albendazole 400 mg) — broad-spectrum benzimidazole anthelmintic for pinworm, roundworm, hookworm, whipworm, and tissue-stage hydatid disease. Single-dose adult therapy from a WHO-GMP certified manufacturer.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is ABD 400?
ABD 400 is een albendazole 400 mg oral tablet — a broad-spectrum antiparasitic active against roundworm, pinworm, hookworm, whipworm, tapeworm, hydatid disease, and neurocysticercosis. Standard adult dose is a single 400 mg tablet for most intestinal worms, repeated at 2 weeks. For hydatid disease and neurocysticercosis, longer courses are required. Take bij een vette maaltijd — absorption rises 5-fold.
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ABD 400 is a Zydus albendazole 400 mg oral tablet — a cornerstone antiparasitic medication for intestinal worms and selected tissue-cyst infections. Albendazole is a benzimidazole antihelminthic with one of the broadest spectra in its class, effective against adult worms, larvae, and in several cases the egg stage.
ABD 400 is on the WHO Model-lijst van essentiële geneesmiddelen and is the backbone of most global deworming campaigns, including school-based mass drug administration programmes that have reduced soil-transmitted helminth prevalence in children across Asia, Africa, and Latin America.
What Is ABD 400?
ABD 400 is a prescription benzimidazole antihelminthic with activity against the organisms that cause most human worm infections:
- Nematodes (roundworms): Ascaris lumbricoides, Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ancylostoma duodenale en Necator americanus (hookworms), Strongyloides stercoralis
- Cestodes (tapeworms): Taenia solium, Taenia saginata, and tissue cysts in neurocysticercosis and hydatid disease (Echinococcus)
- Protozoa: some activity against Giardia en Microsporidia
ABD 400 is not meaningfully active against trematodes (flukes) — praziquantel is preferred for schistosomiasis and most fluke infections.
For scabies, head lice, strongyloidiasis, and onchocerciasis, ivermectin is the first-line choice. See our comprehensive side-by-side guide: Ivermectin vs Albendazole: Which to Choose?
How Does ABD 400 Work?
Albendazole exerts a selective, well-characterised antiparasitic effect:
- After absorption, it is rapidly converted in the liver to its active metabolite albendazolsulfoxide
- The sulfoxide binds to parasite β-tubuline, inhibiting the polymerisation of microtubules
- Without functional microtubules, the parasite cannot maintain its glucose uptake or cellular structure — worm cells become starved of ATP and die
- Mammalian β-tubulin has a different binding site, which is why albendazole is safe for humans at standard doses
- Oral absorption is poor on an empty stomach (<5%) but increases 5-fold with a fatty meal — critical for tissue-stage infections (hydatid, neurocysticercosis)
Plasma half-life of albendazole sulfoxide is 8–12 hours. For intestinal worms, a single dose is usually enough; for tissue-stage disease, courses of weeks to months are required.
Toepassingen en Indicaties
- Ascariasis (roundworm) — single 400 mg dose, >95% cure
- Enterobiasis (pinworm / threadworm) — single dose, repeat at 2 weeks; treat all household contacts
- Hookworm (Ancylostoma, Necator) — single dose; 3-day course for heavy load
- Trichuriasis (whipworm) — 400 mg daily for 3 days gives higher cure than single dose
- Strongyloidiasis — albendazole works, but ivermectin is preferred as first-line
- Taeniasis (tapeworm) — 400 mg daily for 3 days
- Neurocysticercosis (brain cysts from T. solium) — 15 mg/kg/day in divided doses for 8–30 days with corticosteroid cover
- Hydatid disease (E. granulosus) — 400 mg twice daily for 28-day courses, often multiple cycles
- Giardiasis — alternative to metronidazole or tinidazole
- Mass drug administration programmes — annual or biannual single-dose deworming in endemic regions
ABD 400 Dosage and Administration
| Indicatie | Adult Dose | Schedule |
|---|---|---|
| Ascariasis, hookworm, pinworm | 400 mg | Single dose; repeat at 2 weeks for pinworm to cover egg re-cycling |
| Whipworm (trichuriasis) | 400 mg | Once daily for 3 days |
| Tapeworm (Taenia) | 400 mg | Once daily for 3 days |
| Strongyloidiasis | 400 mg | Twice daily for 7 days (ivermectin is preferred first-line) |
| Hydatid disease | 400 mg | Twice daily × 28-day course; typically 3 cycles with 14-day breaks |
| Neurocysticercosis | 15 mg/kg/day | Divided every 12 hours for 8–30 days; with steroid and anticonvulsant cover |
| Giardiasis | 400 mg | Once daily for 5 days |
| Children ≥2 years (intestinal worms) | 400 mg | Same as adult — mass-drug-administration dose in school-age children |
| Children 1–2 years | 200 mg | Half tablet for pinworm / ascariasis |
| Leverfunctiestoornis | Caution; monitor LFTs | Albendazole and its metabolite accumulate |
How to Take ABD 400 Properly
- Slik de tablet heel door met water
- Take with a fatty meal — albendazole absorption rises 5-fold with fat, which is particularly important for hydatid disease and neurocysticercosis
- For pinworm, treat the whole household simultaneously and repeat the dose at 2 weeks — otherwise re-infection from egg recycling is almost guaranteed
- Wash bedding, clothing, and towels in hot water; short fingernails; hand hygiene after toilet and before meals
- For long-course therapy (hydatid disease, neurocysticercosis), monitor liver function and blood count monthly — reversible hepatotoxicity and bone-marrow suppression can occur
- Children with pinworm may need repeated courses because pinworm eggs can survive in bedding and carpets for 2–3 weeks; deep cleaning reduces re-infection risk
Side Effects of ABD 400
Single-dose or short courses of ABD 400 are very well tolerated. Longer courses (hydatid, neurocysticercosis) carry higher risk.
| Ernst | Bijwerking |
|---|---|
| Common (≥1 in 100) — short courses | Mild nausea, abdominal discomfort, headache, dizziness, transient rise in liver enzymes |
| Common with long courses (weeks–months) | More pronounced liver enzyme elevation, mild reversible hair loss, leucopenia |
| Minder vaak | Rash, pruritus, vomiting, fever |
| Neurocysticercosis-specific | Inflammatory reaction as cysts die — worsening headache, seizures, focal neurological symptoms. Always co-administer with corticosteroid cover under specialist supervision |
| Zeldzaam maar ernstig | Severe hepatitis, bone-marrow suppression (pancytopenia, agranulocytosis), Stevens-Johnson syndrome |
Zoek onmiddellijk medische hulp for yellowing of the eyes or skin, severe abdominal pain, unexplained bruising, unusual bleeding, severe widespread rash, or new-onset neurological symptoms during neurocysticercosis treatment.
Waarschuwingen en voorzorgsmaatregelen
- Zwangerschap. Albendazole is teratogenic in animal studies. Avoid in the first trimester. WHO considers single-dose treatment for soil-transmitted helminths acceptable from the second trimester in endemic areas
- Pre-pregnancy. Women of childbearing potential should have a negative pregnancy test before starting long courses (hydatid, neurocysticercosis) and use effective contraception throughout treatment and for 1 month after
- Borstvoeding. Small amounts pass into breast milk; single-dose treatment is considered acceptable. Avoid long courses while breastfeeding where possible
- Long-course monitoring. Monthly full blood count and LFTs during hydatid or neurocysticercosis treatment
- Neurocysticercosis. Never initiate without steroid cover — dying cysts provoke cerebral oedema and can precipitate seizures or obstructive hydrocephalus. Start under specialist supervision in hospital
- Hepatic impairment. Use with caution; consider dose reduction and monitor LFTs
- Children under 1 year. Limited safety data — use only if clearly needed
Contraindications — Who Should NOT Take ABD 400
- Known hypersensitivity to albendazole or any benzimidazole
- First trimester of pregnancy
- Severe hepatic impairment (relative)
- Pre-existing bone-marrow suppression for long-course therapy
Geneesmiddelinteracties
| Geneesmiddel / Klasse | Interactie |
|---|---|
| Dexamethasone, prednisolone | Commonly co-prescribed in neurocysticercosis — raise albendazole sulfoxide levels by ~50%, clinically beneficial |
| Praziquantel | Raises albendazole sulfoxide levels; often co-prescribed for mixed infections |
| Cimetidine | Raises albendazole levels — sometimes used intentionally to boost hydatid cyst penetration |
| Phenytoin, carbamazepine, phenobarbital | Induce CYP metabolism — lower albendazole levels and may reduce efficacy in neurocysticercosis (where these anticonvulsants are often used) |
| Ritonavir | Raises albendazole levels — generally clinically manageable |
| Ivermectine | No pharmacokinetic concern — commonly combined for lymphatic filariasis and broad deworming (see Bandy-Plus) |
| Grapefruitsap | Can raise albendazole sulfoxide levels modestly — avoid large intake with long-course therapy |
Tell your doctor about all prescription and non-prescription medications, including herbal supplements, before starting ABD 400.
Wat te doen bij overdosering
Acute overdose typically causes gastrointestinal upset only. There is no specific antidote. Management is supportive. Contact your local poisons service for large ingestions or paediatric accidental overdose.
Bewaaradvies
- Bewaren onder 30 °C op een droge plaats, uit direct zonlicht
- Bewaren in de originele blisterverpakking
- Buiten bereik van kinderen houden
- Niet gebruiken na de vervaldatum die op de verpakking staat vermeld
- Ongebruikte tabletten inleveren bij een apotheek met innameprogramma, indien beschikbaar
Gerelateerde alternatieven op MedsBase
Looking for related antiparasitic options?
- Wormentel — alternative albendazole brand
- Bandy-Plus — albendazole + ivermectin combination for broad-spectrum deworming
- Mebex — mebendazole, a related benzimidazole alternative
- Ivermectol — ivermectin, preferred for scabies and strongyloidiasis
- Iverjohn — alternative ivermectin brand
- Iverheal — Healing Pharma ivermectin
- Guide: Ivermectin vs Albendazole — which to choose
- Browse all Parasitic Infection treatments →
Veelgestelde vragen
What is ABD 400 used for?
ABD 400 is an albendazole 400 mg tablet used for roundworm, pinworm, hookworm, whipworm, tapeworm, hydatid disease, neurocysticercosis, and giardiasis. It is one of the most widely prescribed antiparasitics worldwide.
How should I take ABD 400?
Slik de tablet in zijn geheel in met een fatty meal — this increases absorption 5-fold. For pinworm, repeat the dose at 2 weeks and treat all household contacts simultaneously.
Albendazole or ivermectin — which should I use?
Albendazole is first-line for intestinal worms (roundworm, pinworm, hookworm, whipworm), tapeworm, hydatid disease, and neurocysticercosis. Ivermectine is first-line for scabies, strongyloidiasis, onchocerciasis, and head lice. For a full comparison see our Ivermectin vs Albendazole guide.
How fast does ABD 400 work?
For intestinal worms, symptoms usually improve within 24–72 hours. For tissue-stage disease (hydatid, neurocysticercosis) improvement takes weeks to months and is tracked on imaging, not symptoms.
Why do I need a second dose after 2 weeks for pinworm?
Pinworm eggs can survive in the environment for 2–3 weeks. The first dose kills the adult worms but may not eliminate larvae that hatch from already-laid eggs. A second dose at 2 weeks catches the next generation before they can lay new eggs.
Do I need to treat my whole family?
Yes for pinworm — transmission is efficient within households. Everyone in the house should be treated on the same day and the repeat dose given to all simultaneously at 2 weeks. Wash bedding, towels, and clothing on the treatment day.
Is ABD 400 safe in pregnancy?
Avoid in the first trimester due to teratogenic potential in animal studies. Single-dose treatment in the second and third trimesters is considered acceptable in endemic regions per WHO guidance. Use contraception during long-course therapy and for 1 month after.
Can I give ABD 400 to children?
Yes — the 400 mg dose is standard for school-age children in mass-drug-administration programmes. For children aged 1–2 years, halve the dose (200 mg). Below age 1, use only if clearly needed under paediatric guidance.
What if my symptoms don’t resolve?
Persistent symptoms after a single dose may mean: (a) wrong diagnosis (not a worm), (b) a worm not covered by albendazole (schistosoma — use praziquantel), (c) re-infection from untreated contacts or environment, (d) heavy infestation needing a 3-day course. Review with your doctor.
Does ABD 400 treat scabies?
No — scabies is an ectoparasite (mite) and is treated with oral ivermectin or topical permethrin. Albendazole has no useful activity against scabies.
Can I drink alcohol with ABD 400?
Moderate alcohol intake with short courses is usually fine. Avoid alcohol during long courses (hydatid disease, neurocysticercosis) because of additive hepatotoxic risk.
For users running protocols that specifically pair ivermectin with fenbendazole rather than albendazole, our Ivermectine & Fenbendazol Combinatiepakket bundles those two molecules at a combined-pack price.
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Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 400 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
ABD 400 (Albendazole)
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ABD 400 (Albendazole)
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