Placentrex Gel

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What Is Placentrex Gel?

Placentrex Gel is a topical 0.25% fresh placenta extract gel from Albert David Ltd, supplied in a 20 g tube. The active substance is an aqueous extract of full-term human placenta that has been screened for HIV, hepatitis B, hepatitis C and syphilis, then viral-inactivated by heat and solvent-detergent treatment before fractionation. The extract contains amino acids (including glycine, proline, hydroxyproline), nucleotides, polypeptides, growth-factor-like compounds, trace minerals and enzymes that have been shown in Indian and Russian clinical studies to accelerate granulation and re-epithelialisation of chronic wounds.

The approach dates back to Russian ophthalmologist V.P. Filatov, who in the 1930s proposed that tissue extracts contain “biogenic stimulators” released under stress conditions that accelerate healing when applied to damaged tissue. Placental extract entered Indian pharmacopoeial use in the 1960s and has remained in continuous clinical use there for more than 60 years across dermatology, general surgery, gynaecology, dentistry and chronic-wound clinics. It is not FDA-approved and is not part of standard wound-care guidelines in the US, UK, EU or Australia, where recombinant growth-factor products (e.g. becaplermin) and specialised dressings dominate instead. Regulatory status varies by country; availability and indication labelling in India, Bangladesh, Sri Lanka and parts of Eastern Europe is wide.

How Does Placentrex Gel Work?

Placental extract acts on multiple phases of the wound-healing cascade:

• Stimulates granulation tissue formation — the matrix of new capillaries, fibroblasts and extracellular matrix that fills a wound bed and provides the scaffold for re-epithelialisation. Granulation is the rate-limiting step for most chronic wounds.
• Accelerates re-epithelialisation — the advance of keratinocytes from the wound margins across the granulation bed. Animal studies and open Indian clinical trials suggest a 30-50% reduction in time-to-closure for well-selected chronic wounds.
• Delivers exogenous amino acid and nucleotide substrates for the protein-hungry healing wound bed — plausibly useful in malnourished patients or large wounds with high metabolic demand.
• Modulates local inflammation — preclinical data suggest reduced TNF-α and improved TGF-β balance within the wound microenvironment.
• Minimal systemic absorption from intact skin and small-area topical application; the gel vehicle does not carry meaningful drug across the dermal barrier. Systemic pharmacokinetics are therefore not clinically relevant for topical use.

Evidence grade: most supportive data come from open-label Indian trials and uncontrolled case series rather than large double-blind randomised trials. It is a reasonable adjunct in well-selected chronic-wound patients where standard wound-care alone is plateauing, particularly in settings where modern recombinant growth-factor products are unavailable or unaffordable. It is niet a replacement for the fundamentals of chronic-wound management: infection control, debridement, pressure offloading, glycaemic optimisation, compression for venous ulcers, nutritional support.

When Placentrex Gel Is Used

Placentrex Gel has a wide traditional use pattern in Indian practice. Commonly applied for:

• Chronic non-healing ulcers — diabetic foot ulcers (after debridement and glycaemic control), venous leg ulcers (alongside compression therapy), pressure ulcers (alongside pressure offloading), ischaemic ulcers (after vascular optimisation where possible)
• Post-radiation ulcers and radiation-dermatitis recovery after head-and-neck, breast, pelvic or skin cancer radiotherapy
• Episiotomy and perineal tears during the post-partum healing phase
• Superficial burns after initial wound cleaning and establishment of a clean granulating base
• Surgical wounds with delayed healing — post-operative cavities, stoma sites, dehiscence
• Dental/oral ulcers and post-extraction sockets (dental gel formulations)
• Anorectal fissures and post-haemorrhoidectomy healing
• Cervical erosion and related gynaecological indications (specialist use only)

Placentrex Gel is NOT a first-line treatment for:

• Actively infected wounds — infection must be addressed first with appropriate antimicrobials, debridement and culture-guided systemic therapy
• Deep cavitating wounds requiring surgical repair, skin grafting or flap reconstruction
• Malignant wound surfaces (e.g. fungating tumours) — placental extract should not be used where unchecked tissue proliferation is already the problem
• Acute deep burns (third-degree and deeper second-degree) requiring burn-unit management

Placentrex Gel Dosage and How to Apply

1. Clean the wound gently with saline or a mild, neutral wound-cleanser; remove slough and loose necrotic tissue (sharp debridement by a clinician if needed). Pat the surrounding skin dry.
2. Apply a thin uniform layer of Placentrex Gel directly onto the wound bed and a short overlap onto the wound margin. A pea-sized amount typically covers 3-4 cm². Do not pack the gel into deep cavities in large quantities — a thin film is sufficient.
3. Cover with a non-adherent dressing appropriate to the wound type (e.g. non-stick primary dressing + absorbent secondary for exuding wounds; simple occlusive dressing for dry wounds). Compression dressings for venous ulcers are applied over the top.
4. Apply once or twice daily. Frequency is titrated against exudate level and dressing-change schedule. Heavily exuding wounds may need daily changes; stable granulating wounds can usually be changed every 2-3 days.
5. Typical treatment duration: 2-6 weeks, extended to 8-12 weeks for hard-to-heal diabetic or venous ulcers under medical review. If no measurable progress (reduction in wound surface area, depth, or slough) after 4 weeks, re-evaluate the overall wound-care plan — placental extract alone will not fix an ulcer with unaddressed infection, ischaemia, pressure, or glycaemic failure.
6. Do not use on your face or mucous membranes unless specifically instructed by a clinician. A dental-gel formulation exists for oral ulcers — do not substitute the skin formulation for it.
7. Wash hands before and after application; use gloves if applying to someone else’s wound.

Kinderen: used in paediatric dermatology in India; specific dosing decisions should be guided by the treating clinician. Zwangerschap en borstvoeding: topical placental extract has minimal systemic absorption and has been used widely in Indian obstetric practice (for episiotomy healing) — use under obstetric or midwife supervision.

Bijwerkingen

• Common (mild): local stinging or warmth on application (usually resolves within minutes), transient redness of the wound margin
• Minder vaak voorkomend: contact dermatitis, delayed-type hypersensitivity, local pruritus
• Zeldzaam: urticaria or generalised hypersensitivity reactions (biological product — patients with a history of allergy to animal-derived or biological preparations should be cautious)
• Very rare (historical concern): transmission of infectious agents. Modern manufacturing pipelines use pooled donor screening (HIV, HBV, HCV, syphilis) and viral-inactivation steps (heat treatment, solvent-detergent), making this risk extremely low with licensed products from reputable manufacturers. It is not zero — the same principle as for pooled plasma-derived medicines.

Contra-indicaties & waarschuwingen

• Known hypersensitivity to placental extract or any excipient
• Malignant or premalignant lesions — placental extract promotes tissue proliferation and is not appropriate for use on or around actively malignant tissue
• Actively infected wounds prior to infection control — treat infection first with appropriate antimicrobials
• Deep-tissue wounds requiring surgical repair (grafting, flap) — topical products do not substitute for surgical closure
• Severe deep burns requiring burn-unit management
• Unexplained chronic wounds without a diagnosis — chronic non-healing wounds can be the presenting feature of vasculitis, pyoderma gangrenosum, cutaneous malignancy and other serious pathologies; a clinical diagnosis should come first

A note on regulatory status. Placental extract preparations are widely used in India, Bangladesh, Sri Lanka, Nepal, parts of Eastern Europe and Latin America, and in some East Asian countries. They are niet FDA-approved in the United States and are not routinely used in UK, EU, Australian or Canadian practice, where recombinant growth-factor products and advanced wound-care dressings dominate chronic-wound management. Clinicians outside the Indian-pharmacopoeial tradition may be unfamiliar with this product. Patients travelling internationally should be aware of regional regulatory differences.

Geneesmiddelinteracties

Topical Placentrex Gel has minimal systemic absorption and no clinically documented systemic drug interactions. Local interactions to manage:

• Other topical products — do not layer different topical preparations on the same wound bed simultaneously; separate application or, ideally, use one topical at a time based on the clinical need of that phase of healing
• Topical antiseptics (chlorhexidine, povidone-iodine, hydrogen peroxide) — these may denature the biological active and reduce the efficacy of the extract. If antiseptic cleansing is needed, rinse thoroughly with saline before applying placental extract
• Topical corticosteroids — steroids suppress fibroblast activity and can counteract the pro-healing action; avoid co-application unless specifically directed by a clinician
• Silver-containing dressings and antimicrobials — can coexist in the same dressing change if there is active colonisation/infection concern, but temporal separation is preferred

Opslag en houdbaarheid

Store Placentrex Gel below 25°C in a cool dry place, away from direct sunlight. Do NOT freeze (the biological actives may denature). Replace cap tightly after use. Keep out of reach of children. Use within 30 days of first opening or before the printed expiry date, whichever is sooner.

Veelgestelde vragen

Is Placentrex Gel safe? It’s made from human placenta — what about infection risk?

Licensed placental extract is manufactured from donor placentas that have been screened for HIV, hepatitis B, hepatitis C and syphilis, and then viral-inactivated by heat and solvent-detergent treatment before fractionation. This parallels the manufacturing pipeline for plasma-derived medicines (immunoglobulins, albumin, clotting factors) and is considered to give a very low residual infectious-risk profile. The risk is not zero in principle, but modern manufacturing has made real-world transmission events extremely rare. If you have concerns, ask your supplier for the manufacturer’s viral-inactivation documentation.

Can I use Placentrex Gel on a diabetic foot ulcer?

Yes — this is a classic Indian indication, used alongside the core interventions: glycaemic control (HbA1c under 7-8%), pressure offloading (total contact casting or a removable cast walker), sharp debridement of slough, infection treatment if present, and vascular assessment if the foot is ischaemic. Placentrex Gel alone will not heal a diabetic foot ulcer — the underlying pressure, perfusion and glycaemic problems must be addressed simultaneously. Do not use if there is active osteomyelitis or deep infection until those are under control.

Is Placentrex Gel FDA-approved?

No. Placental-extract wound-healing products are not FDA-approved in the United States and are not part of standard wound-care guidelines in the US, UK, EU or Australia. They are widely used in India, Bangladesh and parts of Eastern Europe and Latin America under those countries’ respective regulatory frameworks. If you are in a jurisdiction where these products are unlicensed, speak to your clinician about locally-approved alternatives (recombinant PDGF, specialised dressings, hyperbaric oxygen).

Hoelang duurt het voordat ik resultaten zie?

Most wounds that are going to respond show measurable reduction in wound surface area within 2-4 weeks. Full closure depends on wound size, location and underlying conditions — small episiotomy-type wounds may close in days; large chronic ulcers can take 8-12 weeks or longer. If no measurable progress (reduction in wound size, depth, or slough) after 4 weeks of consistent use alongside good standard wound care, re-evaluate the overall plan — there is almost always an unaddressed underlying factor (infection, ischaemia, pressure, glycaemia, nutrition).

Can I use Placentrex Gel on a fresh surgical wound or episiotomy?

Yes — this is a common Indian obstetric and post-surgical indication. Used on clean, closed surgical wounds and episiotomy sites to accelerate healing. Apply a thin film 1-2 times daily after gentle cleaning. Do not apply before a wound has been closed (sutured or taped) — for open surgical cavities, use under surgical supervision.

Can I use Placentrex Gel on my face or for cosmetic anti-ageing?

This product is labelled and priced for therapeutic wound-healing use, not cosmetic application. There is a separate category of cosmetic “placental extract” serums and creams sold by the beauty industry, but their composition, sterility and evidence base differ markedly from licensed therapeutic placental-extract preparations. Do not use a therapeutic wound-care product for routine cosmetic face application — the evidence supporting it for that use is weak, and the regulatory framing is different.

Is it safe in pregnancy or breastfeeding?

Topical placental extract has minimal systemic absorption and has been used widely in Indian obstetric practice (for episiotomy and post-partum perineal healing). Use under obstetric or midwife supervision. Systemic and mucosal applications in pregnancy are a different clinical situation and should only be under specialist care.

Where can I order Placentrex Gel online?

You can order Placentrex Gel from MedsBase in standard pack sizes (20 g tube). Orders ship worldwide with discreet packaging. Because regulatory status varies by country, import rules for biological wound-care products differ by jurisdiction — check your local regulations before ordering.

Related Wound-Care and Skin Products on MedsBase

• T-Bact Ointment (mupirocin 2%) — topical antibiotic for infected wounds and impetigo
• Permite Cream (permethrin 5%) — scabicide (if parasitic infestation is driving skin changes)
• Tenovate Cream (clobetasol) — very-potent topical steroid for severe inflammatory dermatoses

Handige lectuur: MedsBase klantbeoordelingen.

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