Baclof Vloeistof (Baclofen Oraale Oplossing 5 mg/5 ml) — Verlichting van spasticiteit
✅ Relieves muscle stiffness
✅ Reduces muscle spasms
✅ Improves muscle movement
✅ Enhances mobility
✅ Alleviates muscle pain
Baclof Liquid contains Baclofen.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
Snelle antwoord
Baclof Liquid is a ready-mixed oral solution of baclofen 5 mg per 5 ml (1 mg/ml). It is the preferred formulation for children, elderly patients with swallowing difficulty, and adults during dose titration who need fine 1 mg increments. Baclofen relaxes overactive muscles by acting on GABA-B receptors in the spinal cord, easing spasticity from multiple sclerosis, cerebral palsy, and spinal cord injury. Shake well before each dose, measure with the supplied oral syringe, and never stop suddenly.
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What Is Baclof Liquid?
Baclof Liquid is an oral solution containing the muscle relaxant baclofen at a concentration of 5 mg per 5 ml. The liquid format is bioequivalent to baclofen tablets but allows precise small-step dose adjustments and easier administration when tablets are unsuitable — typically children, patients with dysphagia, those fed via a nasogastric or PEG tube, or adults who simply prefer liquids.
How Baclofen Works
Baclofen is a GABA-B receptor agonist that acts at the level of the spinal cord. By binding presynaptic and postsynaptic GABA-B receptors it inhibits the release of excitatory amino acids (glutamate, aspartate) and reduces motor neuron excitability, which relaxes hyperactive skeletal muscles without acting directly on the muscle fibre itself. This central mechanism distinguishes baclofen from peripheral relaxants such as dantrolene.
Indicaties
- Spasticity from multiple sclerosis
- Spasticity from spinal cord injury or disease (trauma, transverse myelitis, syringomyelia)
- Cerebral palsy in children and adults
- Stroke-related and traumatic brain injury spasticity (specialist setting)
- Trigeminal neuralgia — off-label adjunct
- Severe muscle stiffness from motor neuron disease (palliation)
Dose & Administration
| Populatie | Startdosis | Titratie | Typical maintenance |
|---|---|---|---|
| Adults | 5 ml (5 mg) three times daily | +5 ml per dose every 3 days | 30–80 mg/day in 3–4 divided doses |
| Elderly (>65) | 2.5 ml (2.5 mg) twice daily | Slow incremental steps | Lowest effective dose |
| Children 1–2 years | 2.5–7.5 mg/day in 4 divided doses | Specialist guidance | 10–20 mg/day |
| Children 2–6 years | 10–15 mg/day in 4 divided doses | Specialist guidance | 20–30 mg/day |
| Children 6–10 years | 20–30 mg/day in 4 divided doses | Specialist guidance | 30–60 mg/day |
| Nierfunctiestoornis | Reduce — typically half normal | Slow titration | Avoid in severe RI |
Veelvoorkomende bijwerkingen
- Drowsiness, sedation
- Dizziness, light-headedness on standing
- Muscle weakness — sometimes excessive (over-relaxation)
- Misselijkheid, droge mond
- Constipation or, less often, diarrhoea
- Hoofdpijn
- Mild confusion (especially in older patients)
Serious Side Effects — Seek Urgent Care
- Severe drowsiness with shallow breathing (especially with opioids or alcohol)
- Seizures (most often during withdrawal)
- Hallucinations or new-onset psychosis
- Worsening depression with suicidal ideas
- Urineretentie
- Severe allergic reaction (rash, swelling, breathing difficulty)
Contra-indicaties
- Known hypersensitivity to baclofen or any solution excipient
- Actieve maagzweer
- Phenylketonuria (if formulation contains aspartame — check excipients)
Use with extra caution: renal impairment (baclofen is 70–80% renally excreted), psychiatric disorders, autonomic dysreflexia, Parkinson disease, severe respiratory disease, pregnancy, and breastfeeding.
Geneesmiddelinteracties
- Opioids, benzodiazepines, sleep aids, antihistamines, alcohol — additive CNS and respiratory depression
- Tricyclic antidepressants — additive muscle weakness
- Antihypertensives — enhanced blood pressure lowering
- Levodopa / carbidopa — possible hallucinations, confusion
- Lithium — risk of hyperkinetic symptoms
Opslag
Store below 25 °C, tightly capped, away from direct sunlight. Do not freeze. Once opened, use within the period stated on the bottle label (commonly 28 days). Discard the unused portion after that period — even if liquid remains. Keep out of reach of children.
Veelgestelde vragen
Is Baclof Liquid as effective as baclofen tablets?
Yes. The active ingredient and absorption profile are bioequivalent at the same total daily dose. The liquid simply allows finer dose steps and easier swallowing.
Can children take Baclof Liquid?
Yes — baclofen oral solution is widely used in paediatric spasticity (cerebral palsy, spinal cord injury). Doses are weight-based and must be calculated by a paediatrician. Never extrapolate adult doses to children.
Can Baclof Liquid be given through a feeding tube?
Yes. Baclofen oral solution flushes well through nasogastric and PEG tubes. Flush the tube with 10–20 ml of water before and after each dose to prevent blockage.
How quickly does Baclof Liquid start working?
Liquid baclofen reaches peak plasma levels in 30–60 minutes — slightly faster than tablets. Initial muscle-tone reduction is often noticed within 1–2 hours, but full benefit needs 1–2 weeks of titrated dosing.
Wat als ik een dosis vergeet?
Take the missed dose as soon as you remember, unless your next dose is due within 2 hours. Never double up. If you miss several doses, contact your doctor — withdrawal can begin within 24–48 hours.
Is alcohol safe with Baclof Liquid?
Avoid alcohol. The combination significantly worsens drowsiness, falls risk, and slowed breathing. This is true even at small alcohol doses.
Can I switch from tablets to Baclof Liquid?
Yes — switch on a milligram-for-milligram basis. 10 mg of tablets equals 10 ml of Baclof Liquid. Discuss the change with your prescriber if you are on more than 60 mg/day.
Does Baclof Liquid cause weight gain?
Weight changes are uncommon. Some patients report mild fluid retention or appetite changes, but baclofen does not have the metabolic profile of antipsychotics or steroids.
Is Baclof Liquid sugar-free?
Most baclofen oral solutions are sugar-free and contain a sweetener such as sorbitol. Patients with fructose intolerance or phenylketonuria should check the specific excipient list on the bottle.
Can I take Baclof Liquid with food?
Yes — and it is generally better tolerated when taken with or shortly after food, which reduces nausea.
Does baclofen affect my driving?
Drowsiness, dizziness, and slowed reflexes are common. Do not drive or operate dangerous machinery until you know how the medication affects you, particularly during dose titration.
Zie ook: Gabasign 300 / 600 mg — Cipla’s gabapentin generic — same FDA-approved molecule, full dose range from 300 mg starter to 600 mg maintenance.
Zie ook: Synaptol 150 mg — tolperisone alternative when cyclobenzaprine sedation is unacceptable — centrally acting without H1 antihistamine drowsiness.
When sedation from Baclof Liquid (baclofen oral solution) limits daytime use, Synaptol (tolperisone 50 mg) is a non-sedating centrally-acting muscle relaxant that controls spasm and spasticity without the drowsiness that drives many patients off baclofen therapy.
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Baclof Vloeistof (Baclofen Oraale Oplossing 5 mg/5 ml) — Verlichting van spasticiteit
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Baclof Vloeistof (Baclofen Oraale Oplossing 5 mg/5 ml) — Verlichting van spasticiteit
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