Impect
Impect (ivermectin 12 mg) — oral tablet for strongyloidiasis, scabies, head lice, river blindness, and lymphatic filariasis. WHO essential medicine; single-dose weight-based therapy.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
Quick Answer — What is Impect?
Impect is een oraal ivermectin 12 mg tablet van Sain Medicaments. Ivermectin is the WHO-listed first-line agent for strongyloidiasis, scabies, head lice, and onchocerciasis (river blindness). Standard adult dose is 200 µg/kg as a single dose, repeated at day 7–14 for scabies. Take on an empty stomach with water.
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Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.
What is Impect?
Impect is an oral ivermectin product manufactured by Sain Medicaments, available in 12 mg strengths. Ivermectin is one of the most important drugs in global health — the 2015 Nobel Prize in Physiology or Medicine recognised its discoverers (William Campbell & Satoshi Ōmura) for the contribution it made to controlling river blindness and lymphatic filariasis. Today ivermectin is on the WHO Model List of Essential Medicines and remains first-line for several human parasitic and ectoparasitic diseases.
Mechanism — how ivermectin kills parasites
Ivermectin binds with high affinity to glutamate-gated chloride channels in invertebrate nerve and muscle cells. This opens the channel, hyperpolarises the cell, and paralyses the parasite. Mammalian cells lack glutamate-gated chloride channels (mammalian GABA channels are the closest relative, but ivermectin does not cross an intact blood-brain barrier in normal doses), which is why ivermectin has a wide safety margin in humans.
Ivermectin is highly lipophilic, peaks in plasma at 4–5 hours, and has an elimination half-life of 16–28 hours. Most of the drug is excreted in faeces.
Impect indications
| Indicatie | Dosering | Opmerkingen |
|---|---|---|
| Strongyloidiasis | 200 µg/kg single dose | Repeat at 14 days in immunocompromised; pre-emptive screening before steroids |
| Scabies | 200 µg/kg, repeat at day 7–14 | Treat all household contacts simultaneously; topical permethrin alternative |
| Head lice | 200 µg/kg, repeat at day 7 | Useful when topical pediculicides have failed |
| Onchocerciasis | 150 µg/kg single dose, every 6–12 months | WHO mass-drug-administration regimen |
| Lymphatic filariasis | 200 µg/kg with albendazole 400 mg | Annual MDA combination therapy |
| Cutaneous larva migrans | 200 µg/kg single dose | Often a one-shot cure |
Impect dosage — weight-based
Ivermectin is dosed at 200 µg per kg of body weight for most indications (150 µg/kg for onchocerciasis). Convert as follows:
| Body weight | Approx. dose | Tablet equivalent |
|---|---|---|
| 15–25 kg | 3 mg | 1 × 3 mg |
| 26–44 kg | 6 mg | 1 × 6 mg or 2 × 3 mg |
| 45–64 kg | 9 mg | 1 × 6 mg + 1 × 3 mg |
| 65–84 kg | 12 mg | 1 × 12 mg |
| 85–104 kg | 15 mg | 1 × 12 mg + 1 × 3 mg |
| 105–120 kg | 18 mg | 2 × 6 mg + 2 × 3 mg |
Take on an empty stomach with a full glass of water (food increases bioavailability roughly 2.5×, which can change the safety margin in patients with high microfilarial load).
Bijwerkingen
Ivermectin is generally very well tolerated. The most common side effects are Mazzotti reaction (fever, pruritus, lymphadenopathy, joint pain — caused by dying microfilariae, not the drug itself) in patients with onchocerciasis or lymphatic filariasis. Other reactions:
- Vaak voorkomend: mild dizziness, nausea, transient diarrhoea, headache
- Minder vaak: rash, peripheral oedema, abdominal pain
- Zeldzaam: hypotension, tachycardia, transient transaminase rise
- Very rare: Stevens-Johnson syndrome, encephalopathy (almost exclusively in Loa loa co-infection)
Geneesmiddelinteracties
Ivermectin is metabolised primarily by CYP3A4. Clinically relevant interactions:
- Sterke CYP3A4-remmers (ritonavir, ketoconazole, itraconazole, clarithromycin) — raise ivermectin levels
- Sterke CYP3A4-induceerders (rifampicin, carbamazepine, phenytoin, St John’s wort) — reduce levels
- Warfarine — case reports of INR changes; monitor
- Other GABA-active drugs — theoretical interaction; watch for sedation in patients on benzodiazepines or sodium oxybate
Contra-indicaties
- Hypersensitivity to ivermectin
- Children < 15 kg body weight (limited safety data)
- Loa loa endemic region without pre-screening (severe encephalopathy risk)
- Severe hepatic impairment — use with caution
Opslag
Store Impect below 30°C in the original blister, away from light and moisture. Keep out of reach of children.
Waarom bestellen bij MedsBase
Impect is supplied from a WHO-GMP gecertificeerde fabrikant, discreet verpakt en wereldwijd verzonden. Elke bestelling valt onder onze Reshipment Assurance Policy — u draagt nooit de kosten van een verloren pakket.
Veelgestelde vragen
Is Impect the same as ordinary ivermectin?
Yes. Impect is a brand of ivermectin from Sain Medicaments. The active ingredient, dose strengths, and pharmacokinetics are the same as any other quality-assured ivermectin product.
Should I take Impect on an empty stomach?
Yes. Take Impect with a full glass of water at least 1 hour before food or 2 hours after. A fatty meal can increase plasma levels by roughly 2.5×, which is fine for routine dosing but undesirable in patients with high microfilarial loads.
How quickly does Impect work for scabies?
Itching and rash improve within several days but take 2–4 weeks to resolve fully because dead mites and eggs remain in the skin. A second 200 µg/kg dose at day 7–14 covers any newly hatched mites that escaped the first dose.
Can I take Impect with antibiotics?
Most antibiotics are safe to combine. The macrolide clarithromycin is a strong CYP3A4 inhibitor and may raise ivermectin levels — preferable to use azithromycin or doxycycline if a course is also needed.
Does Impect treat COVID-19?
No. Multiple high-quality randomised trials (TOGETHER, ACTIV-6, COVID-OUT) found no clinical benefit of ivermectin in COVID-19. WHO, FDA, and EMA recommend against off-label use for this indication. Impect is for parasitic and ectoparasitic disease only.
Is Impect safe in pregnancy?
Limited human data; reassuring in mass-treatment programmes. Avoid in the first trimester where alternatives exist. Discuss with a clinician for individualised guidance.
Can I drive after taking Impect?
Most patients tolerate ivermectin without sedation. A minority report mild dizziness in the first 24 hours; if so, postpone driving until you feel normal.
How long does Impect stay in the body?
Plasma half-life is 16–28 hours; the drug is essentially cleared within 5–7 days. The therapeutic effect on scabies persists longer because the drug accumulates in skin.
Does Impect cure all worms?
Ivermectin is most active against nematodes (roundworms, including strongyloides and onchocerca) and ectoparasites (scabies, head lice). It is NOT first-line for tapeworms (use praziquantel or niclosamide) or whipworm (use albendazole).
Can I crush or split Impect?
Conventional ivermectin tablets can be split or crushed if needed, although swallowing whole with water is preferred. The dispersible-tablet format is designed for easier dosing in children.
Andere antiparasitaire medicijnen
- Ivermectol (ivermectin 12 mg)
- Iverheal (ivermectine 3/6/12 mg)
- Ivimec (ivermectin 6/12 mg DT)
- ABD 400 (albendazole 400 mg)
- Bandy-Plus (albendazole + ivermectin)
Meer opties in behandeling van aarsmaden
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 6 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Impect
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