Keto Lotion

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What Is Keto Lotion?

Keto Lotion is a 2% ketoconazole topical lotion (50 ml bottle) — a broad-spectrum imidazole antifungal designed for use on skin and scalp. Ketoconazole 2% is the same concentration used in Nizoral (Janssen, the original brand) and in many other market-specific brands (KZ, Danruf, Fungicide, Ketostar). The lotion formulation is preferred over the cream when treating the scalp or hair-bearing body areas, because it rinses out cleanly without leaving an oily residue.

Keto Lotion is primarily used for Malassezia-driven skin conditions — seborrheic dermatitis, dandruff, and pityriasis versicolor — and for dermatophyte infections (ringworm, athlete’s foot, jock itch). Systemic oral ketoconazole has been largely withdrawn because of hepatotoxicity, but the topical 2% formulation has minimal systemic absorption and an excellent safety track record since launch in the 1980s.

How Does Keto Lotion Work?

Ketoconazole inhibits the fungal enzyme 14-α-demethylase (a cytochrome-P450 enzyme called CYP51). This blocks the conversion of lanosterol to ergosterol, the essential component of fungal cell membranes. Without ergosterol:

• Fungal membranes become leaky — growth is suppressed (fungistatic) and at higher local concentrations the fungus dies (fungicidal)
• Toxic sterol precursors accumulate inside the fungus
• Fungal membrane-bound enzymes lose function

Topical 2% ketoconazole reaches concentrations in the stratum corneum far above the MIC of Malassezia yeasts (which cause seborrheic dermatitis and versicolor) and of common dermatophytes (Trichophyton rubrum, T. mentagrophytes, Epidermophyton floccosum, Microsporum). It also has a mild anti-inflammatory effect independent of the antifungal action — explaining why seborrheic dermatitis improves faster on ketoconazole than on equal-strength clotrimazole.

Toepassingen en Indicaties

• Seborrheic dermatitis — oily, scaly red patches on scalp, face (eyebrows, nasolabial folds), chest, upper back, ear canals
• Dandruff (pityriasis capitis — a mild form of scalp seborrheic dermatitis)
• Pityriasis versicolor (tinea versicolor) — hypopigmented or hyperpigmented macules on trunk and upper arms from Malassezia globosa/furfur
• Tinea corporis — ringworm of the body
• Tinea cruris — jock itch (groin)
• Tinea pedis — athlete’s foot (particularly interdigital)
• Cutaneous candidiasis — intertriginous candidiasis in skin folds, inframammary, axillary, groin
• Pityrosporum folliculitis — itchy papules on chest and back (Malassezia folliculitis)
• Cradle cap (infantile seborrheic dermatitis) — under paediatric supervision

Keto Lotion is niet for: nail fungus (onychomycosis needs oral therapy), systemic fungal infections, mucosal candidiasis (vaginal or oral), scalp psoriasis (may help if there is coexisting seborrheic overlap, but primary psoriasis needs different therapy), or eczema/atopic dermatitis without a fungal component.

Keto Lotion Dosage and How to Apply

How to Apply Keto Lotion Properly

1. Wash your hands before and after every application — prevents re-infecting yourself or spreading the fungus.
2. For skin: ensure the area is clean and dry. Apply a thin film of Keto Lotion to the affected patch plus a 2 cm margin of normal-looking skin. Rub in gently until absorbed.
3. For scalp (dandruff / seborrheic dermatitis): wet hair thoroughly. Apply 5–10 ml of lotion, lather generously, leave for 5 minutes (this contact time is essential), then rinse thoroughly with plain water.
4. For face (seborrheic dermatitis of eyebrows, nasolabial folds, beard area): apply a small amount once daily, avoid the eyes and mouth. Rinse off after 5 minutes if concerned about dryness.
5. Continue for the full course, even when the rash looks clear — stopping early is the commonest cause of relapse. Tinea pedis in particular needs 6 weeks.
6. For pityriasis versicolor: treat the chest, back, shoulders and neck even if pigment changes are only seen in one spot — the fungus is present across a wider area than the pigment change suggests.
7. Keep treated skin dry. Wear cotton/breathable clothing. For tinea pedis, change socks daily and dry well between toes after showering.
8. Maintenance phase: for chronic seborrheic dermatitis and dandruff, use once or twice weekly indefinitely to prevent relapse — this is the standard long-term strategy.

Side Effects of Keto Lotion

Common (mild, usually settle within the first week):

• Mild stinging or burning on application
• Dryness or oiliness of skin
• Itching (may be from the underlying condition rather than the lotion)
• Scalp: hair texture changes, mild dryness

Minder vaak:

• Contact dermatitis (allergic or irritant)
• Hair loss with chronic scalp use (rare; reversible on stopping)
• Folliculitis or acneform eruption
• Local pigmentation changes (more noticeable on darker skin; reversible)
• Mild skin peeling

Rare but stop and seek review:

• Severe allergic contact dermatitis (blistering, weeping, widespread redness)
• Angio-oedema or urticaria
• Worsening of the rash after 1 week of use — suggests misdiagnosis (psoriasis, eczema) or resistance; review with a dermatologist

Waarschuwingen en voorzorgsmaatregelen

• Avoid eyes and mouth. If accidentally in the eyes, rinse immediately with plenty of water.
• Do not apply to broken, weeping or acutely inflamed skin — systemic absorption increases and stinging is severe.
• Recurrent dandruff / seborrheic dermatitis: long-term maintenance use (1–2× weekly) is intentional and recommended — relapse is near-universal after stopping.
• Hair colour / relaxers / perms: ketoconazole can slightly alter treated hair colour, particularly in colour-treated hair. Rinse thoroughly.
• If no improvement after 2–4 weeks, stop and review the diagnosis — psoriasis, eczema, contact dermatitis and rosacea can all look fungal initially.
• Kinderen: safe from 12 months for topical use under medical supervision.
• Zwangerschap en borstvoeding: Pregnancy Category C (topical), but minimal systemic absorption — widely considered safe for topical use during pregnancy. Avoid application to the breasts during breastfeeding to prevent infant ingestion.
• Store tightly closed — contamination from repeated use can introduce bacteria into the lotion.

Contra-indicaties

• Known hypersensitivity to ketoconazole, other azole antifungals (clotrimazole, miconazole) or any formulation excipient
• Children under 12 months for topical use without specialist supervision

Geneesmiddelinteracties

Topical 2% ketoconazole has minimal systemic absorption and clinically significant drug interactions are rare with the lotion form. Unlike orale ketoconazole — a potent CYP3A4 inhibitor with many serious interactions — the topical form does not reach blood levels high enough to affect other drugs in most patients.

Opslag

• Store below 25°C, protected from direct sunlight.
• Keep the bottle tightly closed.
• Do not freeze.
• Discard 3 months after first opening to limit microbial contamination.
• Keep out of reach of children.

Gerelateerde alternatieven op MedsBase

• KZ Cream (ketoconazole 2% cream)
• Micogel Cream (miconazole 2%)

Veelgestelde vragen

Is Keto Lotion the same as Nizoral?

Yes — both contain ketoconazole 2% in a topical lotion. Nizoral is the Janssen original; Keto Lotion is the Indian generic. Clinically interchangeable.

How long until Keto Lotion clears my rash?

Seborrheic dermatitis and dandruff usually visibly improve within 1–2 weeks. Pityriasis versicolor clears within 5 days of twice-daily application, though pigment changes may take months to fully normalise. Tinea corporis and cruris clear in 2–4 weeks. Tinea pedis is the slowest — needs 6 weeks of treatment to prevent relapse. Do not stop early.

Why is tinea versicolor coming back every summer?

Tinea versicolor (pityriasis versicolor) is caused by Malassezia, a yeast that lives naturally on everyone’s skin. When the climate is hot and humid, or when you are sweating a lot, the yeast proliferates and produces the patchy pigment changes. Treatment kills the fungus but does not change your underlying susceptibility. Maintenance (once-weekly Keto Lotion application to the trunk and shoulders during warm months) prevents relapse. Pigment normalisation after successful treatment can take 3–6 months.

Can I use Keto Lotion on my face?

Yes — Keto Lotion is effective for facial seborrheic dermatitis (eyebrows, nasolabial folds, beard area, ear canals). Apply a small amount once daily, leave 5 minutes, rinse. Avoid the eyes. For sensitive facial skin, start with every-other-day application and step up to daily if tolerated. If skin dries out, alternate Keto Lotion with a gentle moisturiser.

Can I use Keto Lotion during pregnancy?

Yes — topical 2% ketoconazole has very low systemic absorption and is widely considered safe for topical use during pregnancy and breastfeeding. Pregnancy Category C labelling applies to oral ketoconazole; the topical form has an excellent safety record. Avoid applying to the breasts immediately before breastfeeding to prevent infant ingestion.

Keto Lotion vs Head & Shoulders (zinc pyrithione)?

Both work for dandruff, by slightly different mechanisms. Zinc pyrithione (Head & Shoulders) and selenium sulphide (Selsun) both inhibit Malassezia and are gentler but slightly less potent than ketoconazole. For mild dandruff, start with a zinc pyrithione or selenium sulphide shampoo — cheaper, widely available. For moderate seborrheic dermatitis with actual redness, scale and itch, ketoconazole 2% is the stronger first-line choice. Alternating a ketoconazole shampoo/lotion with a zinc pyrithione product is a common long-term strategy that prevents resistance.

Will Keto Lotion cause hair loss?

Rarely — scattered case reports of mild hair shedding with chronic use, almost always reversible on stopping. Interestingly, some small trials suggest ketoconazole 2% reduces androgenetic hair loss (male pattern baldness) when used twice weekly, probably via anti-androgenic and anti-inflammatory effects on the scalp. So the net effect on hair is usually neutral or mildly beneficial — not a reason to avoid.

Can I use Keto Lotion on my pet?

Ketoconazole 2% is approved for veterinary use, but human products should not be used on dogs, cats or horses without veterinary advice — dosing and carrier vehicle differ. For pet fungal infections, consult a vet for a species-appropriate product. See also Auriko Ear Drops for pet bacterial otitis externa.

What if I have no improvement after 2 weeks?

Stop the lotion and review the diagnosis. Many rashes that look fungal are actually psoriasis, eczema, contact dermatitis, or rosacea — none of which respond to antifungals. See a dermatologist or GP for a correct diagnosis before trying a stronger antifungal.

Gerelateerde alternatieven

Andere producten in Algemene gezondheid die klanten ook bekijken:

• Solearwax Drop
• Lynx SYP
• Metabolis
• L-Glutathione
• Itratuf

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