Lipicard

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Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.

What Is Lipicard?

Lipicard is an oral lipid-modifying medicine containing fenofibrate (160 mg or 200 mg), manufactured by USV Pharma. Supplied in packs of 30, 60, 90 or 180 capsules. Fenofibrate belongs to the fibric acid derivative (fibrate) class, which also includes gemfibrozil and bezafibrate.

Originator brand: Tricor / Lipanthyl (Abbott / AbbVie). In clinical use since the 1970s, with several reformulations improving bioavailability (micronised fenofibrate 200 mg ≈ nanocrystal 160 mg).

What Is Lipicard Used For?

• Severe hypertriglyceridaemia (> 500 mg/dL / 5.6 mmol/L) — primarily to prevent acute pancreatitis
• Mixed dyslipidaemia with raised triglycerides and low HDL in patients already on an optimised statin
• Diabetic dyslipidaemia — high TG + low HDL (modest CV benefit signal in the FIELD and ACCORD-Lipid subgroup analyses)
• Familial hypertriglyceridaemia and certain rare dyslipidaemias
• Diabetic retinopathy progression — fenofibrate slowed progression in FIELD and ACCORD-Eye, independent of lipid effects; now an indication in some countries

Lipicard is niet a first-line treatment for high LDL cholesterol — statins dominate that space. Fibrates complement statins rather than replace them.

How Does Lipicard Work?

Fenofibrate is a PPAR-α (peroxisome proliferator-activated receptor alpha) agonist. Activation of PPAR-α in the liver alters transcription of dozens of genes in lipid metabolism:

• Increases fatty-acid oxidation in the liver — less triglyceride production
• Increases lipoprotein lipase (LPL) activity — faster clearance of triglyceride-rich VLDL
• Decreases apoC-III expression — apoC-III normally inhibits LPL
• Increases apoA-I and apoA-II — raises HDL
• Shifts LDL particle size from small dense (atherogenic) toward larger, less dense particles
• Ontstekingsremmende effecten in endothelium and vascular smooth muscle

Net lipid effect: triglycerides down 30–50%, HDL up 10–20%, LDL modestly reduced (can paradoxically rise in severe hypertriglyceridaemia as VLDL is converted to LDL). Onset: 2–4 weeks; full effect at 2 months.

Dosering en toediening

Standaard dosering: 160 mg or 200 mg once daily with the main meal (usually dinner). Micronised fenofibrate 200 mg is bioequivalent to nanocrystallised 160 mg — they deliver the same active drug exposure.

• Take with food — fenofibrate is lipophilic and much better absorbed with a fat-containing meal.
• Swallow capsules or tablets whole.
• Miss a dose — take as soon as you remember unless close to the next; do not double up.
• Renale dosering: reduce dose by ~50% if eGFR 30–60; avoid if eGFR < 30. Fenofibrate causes a small reversible rise in serum creatinine (up to 0.1 mg/dL / 10 µmol/L); this is not kidney damage.
• Monitoring: lipid panel at baseline and 6–8 weeks after starting or changing dose; LFTs and U&Es at baseline, then periodically.

Bijwerkingen

Vaak voorkomend:

• Dyspepsia, abdominal pain, nausea
• Mild transaminase elevation (usually asymptomatic)
• Reversible rise in serum creatinine (0.05–0.1 mg/dL); not true renal impairment
• Mild photosensitivity

Zeldzaam maar belangrijk:

• Muscle pain, myositis, rhabdomyolysis — rare in monotherapy; risk rises with statin combination (especially with gemfibrozil, which is contraindicated)
• Cholelithiasis (gallstones) — fenofibrate increases cholesterol excretion into bile; modestly raises gallstone risk
• Pancreatitis — rare idiosyncratic reaction (ironic, given fenofibrate prevents triglyceride-driven pancreatitis)
• Pulmonary fibrosis / interstitial lung disease — very rare
• Hypersensitivity, Stevens-Johnson syndrome — very rare
• Worsening of warfarin anticoagulation (raises INR)

Geneesmiddelinteracties

• Warfarine — significantly raises INR; reduce warfarin dose ~30% and monitor closely.
• Statines — fenofibrate + statin is the safer fibrate combination (much safer than gemfibrozil + statin); monitor CK and symptoms. Never combine gemfibrozil with any statin.
• Bile acid sequestrants (cholestyramine, colestipol) — reduce fenofibrate absorption; take fenofibrate at least 1 hour before or 4 hours after.
• Cyclosporine — additive nephrotoxicity risk; monitor renal function.
• Repaglinide — raised levels with gemfibrozil (not a typical fenofibrate problem).
• Oral hypoglycaemics, insulin — modest additional glucose-lowering.

Who Should Not Take Lipicard?

• Ernstig nierfalen (eGFR < 30)
• Active hepatic disease, including biliary cirrhosis
• Pre-existing gallbladder disease
• Known hypersensitivity to fenofibrate
• Zwangerschap en borstvoeding
• Children — safety not established
• Concomitant gemfibrozil (never combine fibrates)

Opslag

Store Lipicard below 25°C in a dry place, in the original blister. Keep out of reach of children.

Veelgestelde vragen

Is Lipicard a substitute for a statin?

No. Statins are first-line for high LDL cholesterol and have the strongest evidence for reducing heart attacks and strokes. Fibrates lower triglycerides well but have much weaker CV-outcome evidence overall. Fenofibrate is used in addition to a statin when triglycerides are high and HDL is low despite optimal statin therapy, or as monotherapy when triglycerides are very high (> 500 mg/dL) to prevent pancreatitis.

Can I take Lipicard with a statin?

Yes — fenofibrate + statin is the standard fibrate-statin combination. It is much safer than gemfibrozil + statin (which is contraindicated due to severe myopathy risk). Monitor CK if new muscle symptoms develop, and monitor renal function.

Why did my creatinine go up on Lipicard?

Fenofibrate causes a small, reversible rise in serum creatinine (typically 0.05–0.1 mg/dL) via tubular effects, niet true kidney damage. Measured GFR is unchanged. It reverses on stopping. If creatinine rises significantly (> 0.3 mg/dL) or clinical concerns arise, investigate other causes.

Will Lipicard lower my LDL cholesterol?

Only modestly (0–15%) and sometimes not at all (in severe hypertriglyceridaemia, LDL can actually rise as VLDL is converted). Statins remain the drug of choice for lowering LDL.

Does Lipicard help prevent heart attacks?

The evidence is modest and population-specific. The FIELD and ACCORD-Lipid trials did not show a clear overall CV benefit from adding fenofibrate to statin therapy, but subgroup analyses suggest benefit in patients with high triglycerides (> 200 mg/dL) and low HDL (< 40 mg/dL) — the classic diabetic dyslipidaemia pattern. It also reduced progression of diabetic retinopathy independently of lipids.

Where can I buy Lipicard online?

You can order Lipicard (160 mg or 200 mg) from MedsBase in packs of 30, 60, 90 or 180 capsules. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.

Gerelateerde cholesterolmedicijnen

• Lipvas — Atorvastatin
• Crestor — Rosuvastatin 5/10/20 mg (AstraZeneca)
• Rosuline — Rosuvastatin
• Ezedoc — Ezetimibe (aanvulling op statine)
• Simvotin — Simvastatin
• Choltran — Cholestyramine (bile acid sequestrant)
• Bekijk alle medicijnen tegen hoog cholesterol

Waarom bestellen bij MedsBase

Lipicard is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our Reshipment Assurance Policy. Uw betalingsbeschrijving bij betaling per kaart toont de gereguleerde betalingsverwerker (een gereguleerde kaartbetalingverwerker), nooit “MedsBase” of een medicijnnaam.

Gerelateerde alternatieven

Andere producten in Chronische aandoeningen die klanten ook bekijken:

• Carloc
• Dilzem CD
• Pirfenex
• Hydrocort 100 Injectie
• Ciplactin

Meer opties in behandelingen tegen hoog cholesterol

Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.

Ezedoc

US$36.00 – US$124.00Prijsbereik: US$36.00 tot US$124.00

Rosuline

US$18.00 – US$117.00Prijsbereik: US$18.00 tot US$117.00

Lipvas

US$12.00 – US$117.00Prijsbereik: US$12.00 tot US$117.00

Choltran Sachet

US$24.00 – US$94.00Prijsbereik: US$24.00 tot US$94.00