Ovral G

What Is Ovral-G?

Ovral-G is a branded generic combined oral contraceptive containing norgestrel en ethinyl estradiol (EE). It prevents pregnancy through three mechanisms:

• Ovulation suppression (primary) — steady hormone levels prevent the LH surge.
• Cervical mucus thickening — hindering sperm penetration.
• Endometrial thinning — reducing implantation potential.

Strengths: norgestrel 0.5 mg + ethinyl estradiol 0.05 mg. Manufactured by Wyeth/Pfizer.

Progestin Profile: Norgestrel

VTE (clotting) risk: Comparable to levonorgestrel-containing COCs for VTE risk.

Androgenic / other activity: Similar to levonorgestrel. Older formulations may contain higher estrogen doses.

Best-fit users: Established users who tolerate it well. Newer formulations with lower-dose LNG are often preferred for new starters.

Genitale herpes (eerste episode):

• Contraception — ~99% effective with perfect use, ~91% typical use.
• Menstrual cycle regulation — for irregular periods.
• Heavy menstrual bleeding (menorrhagia) — reduces blood loss 50%+.
• Painful periods (dysmenorrhea) — reduces prostaglandin-mediated cramps.
• Mild acne improvement (variable — drospirenone/cyproterone COCs work better).
• Endometriosis pain (off-label, continuous-use regimens).
• Ovarian cyst prevention and reduced ovarian cancer risk with long-term use.

How to Take Ovral-G

1. Start on day 1 of your period for immediate contraceptive protection. Starting at other times requires 7 days of backup contraception.
2. Neem one tablet daily at the same time each day — set a phone alarm. Consistency is critical.
3. Follow the pack order. 21-day packs: take one tablet daily for 21 days, then 7 tablet-free days. 28-day packs: take all 28 tablets consecutively (last 7 are placebo/iron).
4. Expect a withdrawal bleed during the tablet-free / placebo week — lighter than a natural period.
5. After the break, start the next pack on the scheduled day regardless of whether bleeding has stopped.

Missed Pill Rules (CRITICAL — read carefully)

Bijwerkingen

Common, usually transient (improve over 3 cycles): nausea, breast tenderness, headache, mood changes, breakthrough bleeding/spotting, reduced libido, weight-neutral to slight gain.

Minder vaak: migraine, melasma (skin pigmentation), contact-lens intolerance, chloasma.

Serious (rare but important): venous thromboembolism (DVT/PE), arterial thromboembolism (stroke, MI), hypertension, cholestatic jaundice, hepatic adenoma, breast cancer (small increase during use, returns to baseline within 10 years of stopping).

VTE warning signs — STOP and seek urgent medical help: severe leg pain or swelling (DVT), sudden shortness of breath or chest pain (PE), sudden severe headache with neurological symptoms (stroke), severe abdominal pain (mesenteric thrombosis).

Who Should Not Take Ovral-G

Combined oral contraceptives are absolutely contraindicated in:

• Smoking + age ≥35 — dramatic stroke/MI risk increase.
• History of VTE (DVT or PE), thrombophilia (Factor V Leiden, protein C/S deficiency, antiphospholipid antibodies).
• History of stroke, transient ischaemic attack, or coronary artery disease.
• Migraine with aura — significant stroke risk.
• Uncontrolled hypertension (>160/100 mmHg).
• Active or recent (within 10 years) breast cancer.
• Active liver disease (hepatitis, cirrhosis, tumour).
• Known pregnancy or unexplained vaginal bleeding.
• Major surgery with prolonged immobilisation (stop 4 weeks before).
• Breastfeeding under 6 weeks postpartum (reduces milk supply; VTE risk high).
• Severe diabetes with vascular complications.

Geneesmiddelinteracties

• Enzyme inducers (REDUCE contraceptive effect — backup needed): rifampicin, rifabutin, phenytoin, phenobarbital, carbamazepine, topiramate, primidone, some HIV antiretrovirals (ritonavir, efavirenz), St John’s Wort.
• Antibiotics (most do NOT reduce efficacy) — the old advice to use backup during antibiotics applies only to rifampicin/rifabutin. Other antibiotics (amoxicillin, doxycycline, cephalexin) do not reduce COC efficacy for most women.
• Lamotrigine — COCs reduce lamotrigine levels; dose adjustment may be needed.
• Grapefruitsap — may raise estrogen levels modestly; not clinically significant.

Non-Contraceptive Benefits

• ~50% reduction in ovarian cancer risk with 5+ years of use (persists decades after stopping).
• ~50% reduction in endometrial cancer risk.
• Lighter, shorter, more predictable periods.
• Reduced menstrual cramps, mittelschmerz, and PMS symptoms.
• Improved acne (especially drospirenone- or cyproterone-containing COCs).
• Reduction in benign ovarian cysts and fibrocystic breast changes.
• Potential protective effect against pelvic inflammatory disease (thickened cervical mucus).

Opslag

Store at room temperature (15–25 °C / 59–77 °F) in the original blister. Keep out of direct sunlight and humidity. Do not use after the printed expiry date. Keep out of reach of children.

Veelgestelde vragen

How quickly does Ovral-G work?

If started on day 1 of your period, it is effective immediately. Starting any other day requires 7 days of backup contraception (condoms or abstinence).

What happens if I want to get pregnant?

Fertility usually returns within 1–3 months of stopping. Some women conceive the first cycle after discontinuation. Taking folic acid for 3 months before trying is recommended.

Will Ovral-G make me gain weight?

Modern low-dose COCs are generally weight-neutral in placebo-controlled trials. Some women report 1–2 kg changes but this is often fluid retention that resolves after 3 months. Drospirenone-containing COCs (mild diuretic effect) may be weight-favourable.

Can I use Ovral-G to skip my period?

Yes — “tricycling” or continuous use is safe for most women. Skip the tablet-free week and start the next pack directly to delay or skip the withdrawal bleed. Some breakthrough spotting may occur; discuss with a clinician for long-term continuous use.

Is Ovral-G safe if I am overweight?

Moderate obesity (BMI 30–35) does not absolutely contraindicate COCs but increases VTE risk. Progestin-only pills or non-hormonal methods may be preferable if BMI is >35. Discuss with a clinician.

What about breastfeeding?

Combined pills are not recommended for breastfeeding mothers under 6 weeks postpartum (VTE risk + milk supply reduction). Progestin-only pills (mini-pills) are preferred during breastfeeding.

Does Ovral-G protect against STIs?

No. Hormonal contraceptives provide zero protection against STIs. Use condoms as barrier protection against chlamydia, gonorrhoea, HIV, herpes, syphilis, and HPV.

What if I forget a pill?

See the Missed Pill Rules table above. Briefly: 1 pill missed (<24 h late) = take and continue; 2+ pills missed (48+ h late) = take the most recent + 7 days backup.

When should I call a doctor urgently?

Severe leg pain or swelling (possible DVT), chest pain or shortness of breath (possible PE), severe headache with visual/neurological changes (possible stroke), severe abdominal pain, yellowing of skin or eyes (liver problem).

Can I switch from Ovral-G to a different pill?

Yes — start the new pill the day after finishing the current pack (no tablet-free gap) if switching another COC. If switching to a POP, overlap by 7 days. Always consult a clinician if changing due to side effects or health changes.

Related Contraceptive Products

• Yasmin (Drospirenone + EE)
• Yaz (Drospirenone + EE 0.02)
• Ovral-L (Levonorgestrel + EE)
• Loette (LNG + EE ultra-low)
• Duoluton-L (LNG + EE)
• Triquilar (Triphasic LNG + EE)
• Femilon (Desogestrel + EE low-dose)

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