Permite Crème

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What Is Permite Cream?

Permite Cream is a topical permethrin 5% cream from Curatio Healthcare, supplied in a 30 g tube. Permethrin is a synthetic pyrethroid first introduced in the 1980s and remains on the WHO Model List of Essential Medicines as the first-line topical treatment for scabies and head-lice infestation worldwide. Internationally branded as Elimite, Nix, Lyclear (Glaxo), Acticin, Scabacid, and many generics.

How Does Permite Cream Work?

Permethrin is a type-1 synthetic pyrethroid neurotoxin. Werkingsmechanisme:

• Binds reversibly to voltage-gated sodium channels in the parasite’s nerve membranes, prolonging channel opening
• Result: persistent depolarisation, paralysis, and death of the parasite (mite, louse, or larva)
• Mammalian sodium channels are insensitive to permethrin at the doses used topically — this selectivity is what gives permethrin its excellent safety margin in humans (and other mammals)
• Ovicidal activity — permethrin kills both adult mites and most viable eggs, but the second-week repeat dose is recommended to catch any eggs that survived the first application and have hatched in the interim

Onset of effect: parasites are killed within hours of application; visible improvement of skin lesions over 1-4 weeks as dead mites are cleared and the post-scabetic immune response resolves.

When Permite Cream Is Used

Permite Cream is appropriate for:

• Scabies (Sarcoptes scabiei) infestation — the licensed indication and first-line treatment per CDC, WHO, EDF and BSACS guidelines. Whole-body application from neck down for adults; whole-body INCLUDING SCALP for infants and immunocompromised patients (crusted scabies).
• Head lice (pediculosis capitis) — apply to washed and towel-dried hair; leave 10 minutes; rinse; comb out nits with a fine-tooth comb. Repeat at 7-9 days.
• Pubic lice (phthiriasis pubis)
• Crusted (Norwegian) scabies — high-mite-burden form in immunocompromised patients; combined with oral ivermectin and barrier nursing
• Outbreak management in nursing homes, schools, military barracks, refugee camps

Permite Cream Dosage and How to Apply

Permite Cream comes in a 30 g tube at 5% permethrin.

Scabies Treatment Protocol

1. Have a warm (not hot) shower or bath and pat dry. Skin should be cool and completely dry before application; hot or moist skin reduces efficacy.
2. Apply Permite Cream as a thin layer to the entire body from the neck down in adults — including the soles of the feet, between the toes, palms of hands, between fingers, under the nails (use a soft brush), genital area, buttocks, and the cleft. For infants under 2, immunocompromised patients, and crusted scabies, also include the scalp, behind the ears, face (avoiding eyes/mouth), and hairline.
3. A typical adult uses approximately 30 g (1 tube) per application.
4. Leave on for 8-14 hours — usually applied at bedtime and washed off in the morning.
5. Wash off thoroughly with soap and warm water.
6. Repeat the entire application 7 days later — this catches mites that hatch from eggs surviving the first treatment. Skipping this dose is the most common cause of treatment failure.
7. Treat all close contacts simultaneously — household members, sexual partners, anyone with prolonged skin-to-skin contact in the past 6 weeks — even if asymptomatic — to prevent re-infestation. Asymptomatic carriers are common.
8. Wash all bedding, towels, and worn clothing from the past 72 hours at >50°C and dry on a hot setting; or seal non-washable items in plastic bags for 72 hours (mites die without a human host in that window).

Head Lice Treatment Protocol

1. Wash hair with regular shampoo, towel-dry until damp
2. Apply Permite Cream generously to cover all scalp and hair
3. Leave on for 10 minutes
4. Rinse thoroughly with warm water
5. Comb through wet hair with a fine-tooth nit comb to remove dead lice and nits
6. Repeat at 7-9 days to catch any newly-hatched lice from surviving eggs

Children under 2: permethrin is generally considered safe from age 2 months under medical supervision; under 2 months, use should be specialist-supervised.

Zwangerschap: permethrin is the preferred topical scabicide in pregnancy — minimal systemic absorption and decades of safe-use evidence

About efficacy: Permethrin 5% has a single-treatment cure rate of approximately 89-95% for classical scabies when applied correctly with the second-week repeat dose.

Bijwerkingen

Common (mild, usually settles):

• Mild burning, tingling, or stinging at application site
• Dry skin or peeling
• Mild redness or rash
• Numbness (with permethrin) — usually transient
• Persistent itch for 2-4 weeks after successful scabies treatment — this is post-scabetic delayed hypersensitivity to dead mites, NOT treatment failure or drug reaction

Minder vaak:

• Allergic contact dermatitis at application site
• Erythema, eczematous reaction
• Hypersensitivity reactions (rare)

Contraindications and Warnings

• Hypersensitivity to permethrin or any excipient
• Hypersensitivity to chrysanthemums or pyrethroids
• Application to broken or eczematous skin (treat the inflammation first; absorption is much higher through compromised skin)
• Active acute inflammatory dermatosis at the application site
• Application to mucous membranes (eyes, mouth, vagina, urethra interior)
• Application inside the ear canal (potential ototoxicity if tympanic membrane perforated)

When to Use Oral Ivermectin Instead

Topical scabicides are not always practical or sufficient. Oral ivermectin (200 mcg/kg as a single dose, repeated at 2 weeks) is preferred or required in the following situations:

• Crusted (Norwegian) scabies — high-mite-burden form; topical alone is inadequate; combined oral ivermectin + topical permethrin is standard
• Outbreak management in care homes, schools, refugee camps — mass treatment with oral ivermectin is logistically simpler than ensuring proper topical application across many people
• Treatment failure with topical scabicide — including verified correct application + repeat dose
• Patients unable to apply topical correctly — cognitive impairment, severe disability, isolated elderly
• Extensive ezcematous or inflammatory dermatosis where topical application would worsen the inflammation

See: Iverheal (ivermectin 12 mg), Iverjohn (ivermectin).

How Permite Cream Compares to Alternatives

Opslag en houdbaarheid

Store Permite Cream below 25°C in the original tube. Replace cap tightly. Keep out of reach of children. Use within 12 months of first opening, or before the printed expiry date.

Veelgestelde vragen

Why does my skin still itch weeks after Permite Cream treatment?

Itch persists for 2-4 weeks after successful scabies treatment because of a delayed hypersensitivity reaction to dead mites and their proteins still in the skin. This is normal and is NOT treatment failure. Resist the urge to re-apply permethrin; over-treatment can cause irritant dermatitis without killing more mites. Manage post-scabetic itch with regular emollient, oral antihistamines, and crotamiton 10% as needed. Persistent severe itch beyond 4 weeks, new burrows, or spreading rash needs medical review.

Why must I treat everyone in the household?

Scabies has a 4-6 week incubation period from infestation to symptom onset, so household members and close contacts may be infested but not yet itching. Treating only the symptomatic person guarantees re-infestation when the silent carriers eventually become symptomatic. Simultaneous treatment of all close contacts — including asymptomatic ones — is the only way to break the cycle.

Do I really need the second dose at 7 days?

Yes — this is the most important step in scabies treatment success. Permethrin kills adult mites and most viable eggs, but some eggs survive the first application and hatch over the following week. The 7-day repeat catches these newly-hatched mites before they can complete their lifecycle and re-establish infestation. Skipping the second dose is the single most common cause of treatment failure.

Can I use Permite Cream on my child?

Yes — permethrin 5% is generally considered safe from age 2 months under medical supervision. Under 2 months, use should be specialist-supervised. For infants and young children, also apply to the scalp, face (avoiding eyes/mouth), and behind ears — not just neck-down as in adults — because children are commonly infested above the neckline.

Is Permite Cream safe in pregnancy?

Yes — permethrin is the preferred topical scabicide in pregnancy. Decades of safe-use data, minimal systemic absorption, and no teratogenicity signal in observational studies. The 2014 BSACS guidelines specifically endorse permethrin in pregnancy.

What about washing bedding and clothing?

Wash all bedding, towels, and clothing worn in the previous 72 hours at >50°C (130°F) and dry on a hot setting. Items that can’t be washed at high temperature should be sealed in plastic bags for 72 uur — mites die without a human host in this window. Vacuum mattresses, sofas, and carpets but extensive cleaning of the household environment is unnecessary — scabies mites do not survive long off the human body.

When should I see a doctor?

See your doctor if:

• Symptoms have not significantly improved 4 weeks after the second permethrin application
• You see new burrows or fresh papules after treatment (suggests re-infestation or treatment failure)
• Itch is severe enough to disturb sleep or daily function
• The skin develops crusty, thick patches (could indicate crusted scabies, which needs oral ivermectin + barrier nursing)
• You’re pregnant, breastfeeding, or treating a child under 2
• You have eczema, severe psoriasis, or significantly compromised skin

Where can I order Permite Cream online?

You can order Permite Cream from MedsBase in standard pack sizes (30 g tube). Orders ship worldwide with discreet packaging.

Gerelateerde alternatieven

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• Ondem
• Famocid
• Davlexin
• Cynomycin

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