Bambudil

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What Is Bambudil?

Bambudil contains bambuterol — a bis-dimethylcarbamate ester prodrug of terbutaline. The carbamate structure is hydrolysed slowly by butyrylcholinesterase (plasma pseudocholinesterase) to release active terbutaline gradually over 24 hours, achieving once-daily oral β2-agonism. Internationally sold as Bambec (AstraZeneca) and Oxeol.

How Does Bambudil Work?

• Slow hydrolysis by plasma butyrylcholinesterase converts bambuterol to active terbutaline.
• Terbutaline activates bronchial β2-adrenergic receptors, raising cyclic AMP and producing sustained bronchodilation.
• 24-hour duration from a single evening dose — useful for nocturnal symptoms.
• Less dependent on patient inhaler technique than inhaled β2 agonists — a benefit for elderly or coordination-impaired patients.

Toepassingen en Indicaties

• Persistent asthma — add-on bronchodilator alongside ICS, especially when nocturnal symptoms predominate
• COPD with reversible component — adjunct bronchodilator
• Patients who cannot use inhalers reliably — elderly, severe arthritis, cognitive impairment
• Nocturnal asthma — once-daily evening dose covers overnight period

Bambudil Dosage

Side Effects of Bambudil

• Fine tremor (β2 effect)
• Palpitations, mild tachycardia
• Hoofdpijn
• Muscle cramps
• Hypokalaemia at high doses (with diuretics, theophylline, oral steroids)
• Insomnia (less common with evening dosing)

Ernstig — stop en zoek hulp:

• Severe palpitations or arrhythmia
• Ernstige allergische reactie
• Paradoxale bronchospasmen

Waarschuwingen en voorzorgsmaatregelen

• {$brand} is a controller, not a reliever. Keep a SABA for acute attacks.
• Cardiovasculaire aandoeningen: caution with arrhythmias, severe coronary artery disease, hyperthyroidism.
• Pseudocholinesterase deficiency — reduces hydrolysis; bambuterol accumulates and effect prolongs. Halve dose.
• Drug interaction with cholinesterase inhibitors (donepezil, rivastigmine, pyridostigmine, suxamethonium) — bambuterol prolongs their action; suxamethonium-induced apnoea has been reported.
• Zwangerschap en borstvoeding: limited data; inhaled β2-agonists are first-line.

Contra-indicaties

• Hypersensitivity to bambuterol or terbutaline
• Ernstige leverfunctiestoornis
• Concurrent suxamethonium (depolarising muscle relaxant) — relative; warn anaesthetist

Geneesmiddelinteracties

Opslag

• Bewaren beneden 25°C in a cool, dry place away from direct sunlight.
• Keep in original packaging until use to protect from moisture and light.
• Do not use after the expiry date printed on the strip.
• Buiten bereik van kinderen houden.

Gerelateerde alternatieven op MedsBase

• Asthalin Inhaler — salbutamol verlichter
• Budecort Inhaler — budesonide ICS-preventer
• Foracort Inhaler — budesonide + formoterol ICS-LABA
• Tiova Inhaler — tiotropium LAMA voor COPD
• Montair — montelukast LTRA-tablet

Veelgestelde vragen

How is Bambudil different from salbutamol or terbutaline tablets?

Bambudil contains bambuterol — a slow-release prodrug of terbutaline. It provides 24-hour bronchodilation from a single evening dose. Standard terbutaline or salbutamol tablets last 4–6 hours and require 3–4 daily doses.

When is Bambudil useful?

For nocturnal asthma (overnight cover from evening dose), for patients who cannot reliably use inhalers (elderly, severe arthritis, cognitive impairment), or as add-on long-acting β2 agonism alongside ICS.

Is Bambudil a reliever?

No — slow onset (~2 hours to peak). Keep a SABA (Asthalin, Levolin) for acute attacks.

Can I take it during the day instead of evening?

Evening dosing is recommended — covers the overnight period when nocturnal asthma symptoms are common, and timing the side effects (mild tremor) when you are sleeping.

Why warn the anaesthetist?

Bambuterol inhibits plasma butyrylcholinesterase. Suxamethonium (a depolarising muscle relaxant used in anaesthesia) is broken down by the same enzyme — combination can prolong suxamethonium-induced apnoea. Tell any anaesthetist before surgery.

Is Bambudil safe in pregnancy?

Limited data; inhaled β2 agonists are first-line.

Can I take Bambudil with my ICS?

Yes — typically used as oral add-on to ICS (Budecort, Beclate). Modern practice prefers inhaled ICS-LABA combinations (Foracort, Seretide), but oral bambuterol remains useful when inhaler use is impractical.

How fast does Bambudil work?

Onset begins around 2 hours after dose; sustained bronchodilation over 24 hours.

Is Bambudil habit-forming?

No — no dependence or tolerance. Frequent need for additional reliever indicates poor asthma control, not addiction.

Meer opties in Astma/COPD-behandeling

Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.

Asthalin

US$2.00 – US$8.00Prijsbereik: US$2.00 tot US$8.00

Aerocort Inhaler

US$6.00 – US$14.00Prijsbereik: US$6.00 tot US$14.00

Asthalin Respules

US$10.90 – US$27.50Prijsbereik: US$10.90 tot US$27.50