Brufen
✅ Relieves Pain Quickly
✅ Reduces Inflammation
✅ Eases Muscle Aches
✅ Alleviates Headaches
✅ Manages Fever Effectively
Brufen contains Ibuprofen.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Brufen?
Brufen is een Ibuprofen tablet available in 200, 400, and 600 mg strengths. It is a non-selective non-steroidal anti-inflammatory drug (NSAID) widely used for pain, fever, and inflammation — including headache, dental pain, menstrual cramps, musculoskeletal injury, osteoarthritis, and rheumatoid arthritis. Typical adult dose is 400 mg three to four times daily with food; the safest long-term dose is 1,200 mg/day or less.
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Brufen 400 mg is one of the most widely prescribed ibuprofen brands in the world, marketed by Abbott and originally developed by Boots in the 1960s. Ibuprofen is on the WHO Essential Medicines List and has the best overall safety profile of any oral NSAID at low to moderate doses. It is the first-line option for most community-level pain and inflammation because it works predictably, is cheap, and is comparatively gentle on the stomach at 1,200 mg/day or less.
Brufen is available in three tablet strengths:
- Brufen 200 mg — over-the-counter strength, useful for mild pain, fever, and dysmenorrhoea
- Brufen 400 mg — the standard adult dose for moderate pain, post-dental, musculoskeletal injury, and inflammatory flare-ups
- Brufen 600 mg — used under medical supervision for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout
What Is Brufen Used For?
Brufen is indicated for a broad range of acute and chronic pain and inflammatory conditions:
- Musculoskeletale pijn — sprains, strains, soft-tissue injuries, lower back pain
- Post-operative and post-dental pain — including after tooth extraction and minor surgery
- Primary dysmenorrhoea (period pain) — first-line therapy; ibuprofen is more effective than paracetamol for period pain
- Headache and migraine — particularly tension-type headache; also useful in acute migraine with or without a triptan
- Koorts — including viral fever, post-vaccination fever, and fever in adult respiratory infections
- Osteoarthritis and rheumatoid arthritis — symptomatic relief of joint pain and stiffness
- Acute gout — high-dose (2,400 mg/day) for 5–7 days, as an alternative to indomethacin or naproxen
- Juvenile idiopathic arthritis — weight-based dosing under paediatric supervision
Brufen is niet a disease-modifying drug in rheumatoid arthritis — it relieves symptoms but does not slow joint damage. DMARDs such as methotrexate or biologics are needed for that.
How Does Ibuprofen Work?
Ibuprofen is a non-selective NSAID — it blocks both COX-1 (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2 (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.
The therapeutic chain of events is the same for every NSAID:
- Tissue injury or inflammation releases phospholipids from cell membranes
- Phospholipase A₂ converts them to arachidonic acid
- Cyclooxygenase (COX-1/COX-2) converts arachidonic acid to prostaglandins — the molecules responsible for pain, swelling, and fever
- Ibuprofen blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation
Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.
Brufen Dosing
Adults:
- Mild to moderate pain / fever / dysmenorrhoea: 200–400 mg every 4–6 hours as needed, up to 1,200 mg/day
- Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: 400–800 mg three to four times daily under medical review; maximum 3,200 mg/day (rarely used)
- Acute gout: 800 mg three times daily for 2–3 days, then taper
Children (> 6 months, weight-based): 5–10 mg/kg every 6–8 hours, max 40 mg/kg/day, under paediatric supervision.
Take Brufen with food or a glass of milk. Swallow tablets whole; do not crush, break, or chew a 600 mg tablet. If you forget a dose, take it when you remember unless your next dose is due within 2 hours — then skip the missed dose. Never double up.
GI safety — read this before the first dose. Every NSAID, including Brufen, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Brufen with food, use the lowest effective dose for the shortest reasonable time, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.
Who Should Not Take Brufen?
- Known hypersensitivity to Ibuprofen or any NSAID
- Active or recurrent peptic ulcer, GI bleed, or GI perforation
- Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)
- Severe heart failure (NYHA class IV)
- Severe hepatic impairment (Child–Pugh C)
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)
- Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs
Cardiovasculair risico
All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.
Renal (kidney) safety
NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.
Common Side Effects of Brufen
Most short-course users tolerate Brufen well. Reported effects include:
Common (1–10%):
- Indigestion, heartburn, nausea, abdominal discomfort
- Headache, dizziness
- Fluid retention, mild ankle swelling
- Rash, itching
Zeldzaam maar belangrijk:
- Peptic ulcer, GI bleed (black tarry stools, coffee-ground vomit) — stop and seek urgent care
- New or worsening hypertension
- Exacerbation of asthma (“aspirin-sensitive asthma”)
- Acute kidney injury in at-risk patients
Rare serious: aseptic meningitis (especially in SLE), Stevens-Johnson syndrome, severe hepatotoxicity.
Brufen vs Other Pain Relievers
| Geneesmiddel | Klasse | Typical dose | Beste voor |
|---|---|---|---|
| Brufen (ibuprofen) | Non-selective NSAID | 400 mg TDS/QDS | Pain + inflammation |
| Paracetamol | Non-NSAID analgesic/antipyretic | 1 g QDS | Pain + fever, no inflammation |
| Naproxen | Non-selective NSAID | 500 mg BID | Longer-acting option, lower CV risk |
| Diclofenac | Non-selective NSAID | 50 mg TDS | Strong anti-inflammatory |
| Celecoxib | Selective COX-2 | 200 mg OD | Arthritis with GI risk |
Brufen and paracetamol work well together. They act on different pathways, so alternating or combining them is safe (e.g. Brufen 400 mg + paracetamol 1 g) and often more effective than either alone for moderate pain. Never combine Brufen with another NSAID.
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Medisch disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.
Veelgestelde vragen
What is Brufen 400 mg used for?
Brufen 400 mg is used for mild to moderate pain (headache, dental pain, musculoskeletal injury, menstrual pain), fever, and inflammatory conditions including osteoarthritis and rheumatoid arthritis. It is the standard adult ibuprofen dose.
How long does Brufen take to work?
Onset of pain relief is usually within 30–60 minutes after an oral dose, with peak effect at 1–2 hours. The anti-inflammatory effect builds over 1–2 weeks of regular dosing.
Is it safe to take Brufen every day?
Short courses (up to 10 days) are generally safe for healthy adults. Daily use for longer than 2–3 weeks increases the risk of GI, kidney, and cardiovascular problems — use the lowest effective dose, take with food, and ask your doctor about adding a proton pump inhibitor if long-term therapy is needed.
Can I take Brufen with paracetamol?
Yes. Ibuprofen and paracetamol work on different pathways and are commonly combined for stronger pain relief. A typical combination is ibuprofen 400 mg plus paracetamol 1 g, repeated up to four times a day.
Can I take Brufen with aspirin?
Combining Brufen with aspirin is not recommended. Regular ibuprofen can blunt the cardiovascular protection of low-dose aspirin; if both are clinically necessary, take ibuprofen at least 30 minutes after or 8 hours before the aspirin dose, and discuss with your doctor.
Can I take Brufen on an empty stomach?
It is best taken with food or a glass of milk — this reduces gastric irritation without slowing onset significantly. Taking it on an empty stomach is not forbidden but is more likely to cause indigestion.
Is Brufen safe in pregnancy?
Brufen should be avoided after 20 weeks of pregnancy and is absolutely contraindicated in the third trimester (risk of premature closure of the ductus arteriosus). In the first and second trimesters it should be used only under specialist advice.
Can I drink alcohol while taking Brufen?
Occasional light drinking is acceptable for most people. Regular or heavy alcohol use with Brufen increases the risk of gastritis and GI bleeding and should be avoided.
Can I take Brufen if I have high blood pressure?
Yes, but with caution and ideally for short courses only. NSAIDs can raise blood pressure and reduce the effect of ACE inhibitors, ARBs, and diuretics. Monitor your BP at home and discuss long-term use with your doctor.
What is the difference between Brufen and Advil?
Advil is another brand of the same molecule (ibuprofen). At the same strength (e.g. 200 mg or 400 mg), Brufen and Advil are clinically equivalent.
What should I do if I accidentally take too much Brufen?
A single dose up to about 100 mg/kg is usually not dangerous in adults and causes only mild GI upset. Doses above that can cause serious toxicity — call your local poison control centre or attend A&E. Signs to watch for: vomiting, confusion, drowsiness, seizures, or dark stools.
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