Ketanov Injection
✅ Rapid pain relief
✅ Powerful anti-inflammatory
✅ Injectable convenience
✅ Effective post-surgery
✅ Analgesic action
Ketanov Injection contains Ketorolac.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Ketanov Injection?
Ketanov Injection is een ketorolac tromethamine 30 mg/ml ampoule gedurende intramuscular or intravenous administration. It is one of the most potent parenteral NSAIDs available and is used in emergency rooms, day-case surgery, and post-operative recovery for moderate to severe acute pain. Standard adult dose is 30 mg IM every 6 hours (maximum 120 mg/day for ≤ 2 days parenteral, ≤ 5 days total including any oral ketorolac). It is niet used chronically.
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Ketanov Injection is an ampoule of ketorolac tromethamine 30 mg/ml, manufactured by Cipla. Ketorolac injection is used in acute-care settings where strong, fast, non-opioid pain control is needed — emergency rooms for renal colic and major trauma, post-operative recovery areas, day-case surgery units, and peri-operative pain protocols that aim to reduce opioid requirement.
Ketorolac’s parenteral analgesic potency is comparable to low-dose morphine: 30 mg IM ketorolac is broadly equivalent to 6–12 mg IM morphine for moderate post-operative pain, without the sedation, respiratory depression, or abuse potential.
What Is Ketanov Injection Used For?
- Post-operative pain — particularly in day-case surgery and orthopaedic procedures; often combined with paracetamol for an “opioid-sparing” regimen
- Renal colic — kidney-stone pain; parenteral ketorolac is a first-line agent in many ED protocols
- Biliary colic
- Acute musculoskeletal trauma — fractures before definitive treatment, severe soft-tissue injury
- Severe acute migraine — when oral therapy fails or vomiting precludes oral dosing
- Severe dysmenorrhoea — when oral NSAID is not tolerated
- Acute-on-chronic cancer pain — short-term adjunct to opioid therapy under specialist supervision
How Does Ketorolac Work?
Ketorolac is a non-selective NSAID — it blocks both COX-1 (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2 (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.
The therapeutic chain of events is the same for every NSAID:
- Tissue injury or inflammation releases phospholipids from cell membranes
- Phospholipase A₂ converts them to arachidonic acid
- Cyclooxygenase (COX-1/COX-2) converts arachidonic acid to prostaglandins — the molecules responsible for pain, swelling, and fever
- Ketorolac blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation
Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.
Ketanov Injection Dosing
- Adult (> 50 kg, under 65): 30 mg IM or slow IV every 6 hours; maximum 120 mg/day
- Elderly (> 65), body weight < 50 kg, mild renal impairment: 15 mg every 6 hours; maximum 60 mg/day
- Single-dose IM: 60 mg (under 65, normal weight) or 30 mg (elderly, low weight)
- Single-dose IV: 30 mg slow IV push over at least 15 seconds
- Maximum parenteral duration: 2 days
- Maximum total (parenteral + oral) duration: 5 days
The injection is given by a healthcare professional. Self-administration is not appropriate for ketorolac.
When transitioning from injection to oral: first oral dose is given at the time the next parenteral dose would have been due. Total combined therapy still must not exceed 5 days.
GI safety — read this before the first dose. Every NSAID, including Ketanov Injection, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Ketanov Injection with food, use the lowest effective dose for the shortest reasonable time, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.
Who Should Not Receive Ketanov Injection?
- Known hypersensitivity to Ketorolac or any NSAID
- Active or recurrent peptic ulcer, GI bleed, or GI perforation
- Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)
- Severe heart failure (NYHA class IV)
- Severe hepatic impairment (Child–Pugh C)
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)
- Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs
Parenteral ketorolac-specific:
- Suspected or actual cerebrovascular bleeding, intracranial surgery, or bleeding diathesis
- Incomplete haemostasis or high bleeding risk (e.g. on anticoagulants)
- Neuraxial (spinal/epidural) administration — formulation is not intended for this route
- Labour and delivery
- Severe volume depletion — rehydrate first
- Children < 16 years in most jurisdictions
- Prophylaxis before major surgery with high bleeding risk
Cardiovasculair risico
All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.
Renal (kidney) safety
NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.
Side Effects of Ketanov Injection
- Vaak voorkomend: pain at the IM injection site, nausea, dyspepsia, drowsiness, dizziness, sweating, headache
- Zeldzaam maar belangrijk: peptic ulcer and GI bleeding, acute kidney injury (especially in volume-depleted or elderly patients), hypertension, post-operative wound bleeding, elevated liver enzymes
- Zeldzaam: anaphylaxis, severe hepatotoxicity, Stevens-Johnson syndrome, bronchospasm, aseptic meningitis
Seek urgent review for: signs of GI bleeding, breathing difficulty, facial swelling, severe wound bleeding after surgery, reduced urine output, or a widespread rash.
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Medisch disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.
Veelgestelde vragen
What is Ketanov Injection used for?
Ketanov Injection (ketorolac 30 mg/ml) is used for short-term treatment of moderate to severe acute pain — post-operative, renal colic, biliary colic, acute trauma, severe migraine, and severe dysmenorrhoea.
How is Ketanov Injection different from Ketorol DT?
Same molecule (ketorolac). Ketanov is the 30 mg/ml IM/IV injection used in emergency rooms and post-operative care; Ketorol DT is the 10 mg oral disintegrating tablet for step-down or home use. Total combined therapy must stay within 5 days.
How fast does Ketanov Injection work?
Onset is 10–30 minutes IM and within minutes IV. Peak effect at 45–60 minutes IM; duration 4–6 hours per dose.
Is Ketanov Injection as strong as morphine?
For moderate post-operative pain, 30 mg IM ketorolac is comparable to 6–12 mg IM morphine in most studies, without sedation, respiratory depression, or addiction risk. Many hospitals use ketorolac as part of an opioid-sparing regimen.
Can I give Ketanov Injection at home?
No. Ketanov is an IM/IV injection that should be given by a trained healthcare professional. Self-administration is not appropriate because of bleeding risk, potential injection-site problems, and the need for clinical monitoring.
Why can’t I have ketorolac for more than 5 days?
The risk of GI ulcer, GI bleeding, and acute kidney injury rises sharply beyond 5 days of continuous ketorolac therapy. This is a regulatory and clinical limit. After 5 days, your pain should be managed with other NSAIDs, paracetamol, or — if truly necessary — opioids, under medical supervision.
Can Ketanov Injection be combined with paracetamol?
Yes — this combination is standard peri-operative care. Paracetamol 1 g IV or oral plus ketorolac 30 mg IM gives additive, multimodal pain relief.
Can Ketanov Injection be given before surgery?
Usually not as a pre-emptive analgesic in procedures with high bleeding risk. In lower-bleeding-risk surgery, an intra-operative dose is sometimes used under the surgeon’s judgement.
Is Ketanov Injection safe in elderly patients?
Use a reduced dose (15 mg every 6 hours, maximum 60 mg/day) and the shortest possible duration. Elderly patients are particularly at risk of GI and renal side effects.
Does Ketanov Injection cause drowsiness or sedation?
Mild drowsiness is possible, but ketorolac does not cause the heavy sedation seen with opioids.
Is Ketanov Injection safe in pregnancy?
No — ketorolac is contraindicated during labour and delivery and should be avoided from 20 weeks of pregnancy onward. Paracetamol or morphine-equivalent analgesia is preferred.
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| Sterkte | 1 ml |
|---|---|
| Hoeveelheid | 5 Ampoule/s, 10 Ampoule/s, 15 Ampoule/s, 30 Ampoule/s |
Ketanov Injection
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