Nafodil
✅ Improves urinary flow
✅ Reduces prostate size
✅ Verlicht urinewegsymptomen
✅ Enhances bladder emptying
✅ Minimizes urinary urgency
Nafodil contains Naftopidil.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
💡 Snel antwoord
Nafodil is naftopidil, a selective alpha-1D adrenergic blocker used for BPH-related lower urinary tract symptoms (LUTS) — particularly storage symptoms (urgency, frequency, nocturia). Developed in Japan and widely used in East Asia but less common in Western markets. Typical dose: 25–75 mg once daily. Works within days to weeks; distinct side-effect profile vs tamsulosin.
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What Is Nafodil?
Nafodil is a branded generic of naftopidil, an alpha-1 adrenergic blocker with preferential selectivity for the alpha-1D receptor subtype. While tamsulosin targets alpha-1A (predominant in prostate smooth muscle), naftopidil targets alpha-1D (predominant in bladder body and spinal cord). This gives naftopidil a different symptomatic profile:
- Reliable voiding symptom improvement (weak stream, hesitancy)
- Stronger effect on storage symptoms (urgency, frequency, nocturia) than tamsulosin — a clinical advantage for men whose main complaint is frequent, urgent urination
- Lower rate of ejaculatory dysfunction vs tamsulosin (alpha-1A is responsible for ejaculation-related smooth-muscle control)
Strengths available: 25 mg, 50 mg, 75 mg. Manufactured by Emcure.
Genitale herpes (eerste episode):
- BPH with predominant storage symptoms — urgency, frequency, nocturia. Naftopidil often outperforms tamsulosin in this subgroup.
- Hypertensie (off-label in most markets) — naftopidil has modest blood-pressure lowering effect.
- Men on tamsulosin with bothersome ejaculatory side effects — switching to naftopidil often preserves sexual function.
Hoe in te nemen
- Swallow the tablet whole with water. Take once daily at roughly the same time each day — no specific meal timing required.
- Typical starting dose: 25 mg once daily. Escalate to 50 mg after 2–4 weeks if symptoms persist, then 75 mg maximum.
- First dose is ideally taken in the evening — orthostatic hypotension risk is highest with the initial dose.
- Symptomatic improvement begins within 1–2 weken, peak effect by 4–8 weeks.
- Do not stop abruptly — symptoms return. Long-term daily use is typical.
Bijwerkingen
Vaak (≥1%): dizziness, headache, orthostatic hypotension, somnolence, nasal congestion.
Less common than tamsulosin: retrograde/reduced ejaculation. This is naftopidil’s clinical advantage.
Rare serious: syncope, priapism, Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery — share with ophthalmologist.
Who Should Not Take Nafodil
- Known hypersensitivity to naftopidil or other alpha-blockers
- Severe orthostatic hypotension history
- Ernstige leverfunctiestoornis
- Planned cataract / glaucoma surgery without informing ophthalmologist
- Not indicated for women
Geneesmiddelinteracties
- Andere alfa-blokkers: additive hypotension — do not combine.
- PDE5-remmers: additive hypotension. Space doses; tadalafil 5 mg daily is often pragmatic.
- Antihypertensiva: monitor for excessive blood-pressure drop.
- CYP3A4 substrates: naftopidil is extensively metabolised; major interactions uncommon but caution with strong inhibitors.
Naftopidil vs Tamsulosin
Both are selective alpha-blockers for BPH, but they target different receptor subtypes — tamsulosin prefers alpha-1A (more prostatic), naftopidil prefers alpha-1D (more bladder body). Clinical implications:
- Tamsulosin is better for voiding symptoms (weak stream, hesitancy) and in Western evidence-based guidelines as first-line.
- Naftopidil is often better for storage symptoms (urgency, frequency, nocturia) and for men with bothersome ejaculatory side effects on tamsulosin.
- Regional availability: naftopidil is standard in Japan / East Asia; less common in the US / EU but widely available in India and other Asian markets.
Opslag
Store at room temperature (15–30 °C / 59–86 °F), away from moisture and heat. Keep in original blister. Do not use after the printed expiry date.
Veelgestelde vragen
When should I choose naftopidil over tamsulosin?
Choose naftopidil if your main complaint is urgency, frequency, or nocturia; or if you have had bothersome ejaculation side effects on tamsulosin; or if you prefer a drug with a lower sexual side-effect rate. Tamsulosin remains first-line for Western guidelines for pure voiding-symptom BPH.
How fast does Nafodil work?
Improvement typically begins within 1–2 weeks. Peak effect at 4–8 weeks. Unlike 5-alpha-reductase inhibitors, naftopidil does not shrink the prostate — its effect is pharmacological smooth-muscle relaxation.
Does naftopidil affect ejaculation?
Much less than tamsulosin. Naftopidil’s alpha-1D preference means less effect on bladder-neck closure during ejaculation. This is naftopidil’s main clinical advantage for men who are sexually active.
Can I combine Nafodil with dutasteride?
Yes — alpha-blocker + 5-alpha-reductase inhibitor is a standard combination. Naftopidil addresses symptoms; dutasteride shrinks the prostate over 3–6 months. Not available as a fixed-dose combination, so take separately.
Can I combine Nafodil with tadalafil?
With caution — additive blood-pressure lowering. Tadalafil 5 mg daily is often pragmatic and also treats BPH. Space doses by several hours and monitor for dizziness.
Does Nafodil affect blood pressure?
Modest lowering effect. Not sufficient for hypertension monotherapy in most patients, but enough to cause orthostatic dizziness, especially at initiation. First dose should be at bedtime.
Why is naftopidil less common in the West?
Developed by Japan’s Asahi Kasei Pharma, naftopidil received regulatory approval in Japan (1999) and other East Asian markets but not in the US. Recent studies support its role, particularly for storage-symptom-predominant BPH, and it is increasingly available in generic form globally.
Should I tell my ophthalmologist I am on Nafodil?
Yes — naftopidil is associated with Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery, similar to other alpha-blockers. Tell your ophthalmologist before any eye surgery so technique can be adjusted.
Related BPH Products
- Urimax (Tamsulosin 0.2 mg)
- Urimax Capsule (Tamsulosin 0.4 mg)
- Tamsuheal (Tamsulosin 0.4 mg)
- Monolosin (Tamsulosin 0.4 mg)
- Dutas-T (Tamsulosin + Dutasteride)
- Urimax-F (Tamsulosin + Finasteride)
- Deetor (Dutasteride 0.5 mg)
⚕️ Medische disclaimer: This information is educational and does not replace medical advice. Consult a clinician before starting, stopping, or changing any medication. Prescription products should be used only under medical supervision.
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| Sterkte | 50 mg |
|---|---|
| Hoeveelheid | 10 tabletten, 30 tabletten, 60 tabletten, 90 tabletten, 180 tabletten |
Nafodil
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