Reglan

📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.

Waarom bestellen bij MedsBase

Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.

Waarom bestellen bij MedsBase

Reglan is supplied from a WHO-GMP gecertificeerde fabrikant. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.

Werkingsmechanisme

Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.

Indicaties

• Nausea and vomiting (chemotherapy-induced, post-operative, migraine-associated)
• Diabetic and idiopathic gastroparesis (12-week max under EMA)
• Aspiration prevention pre-anaesthesia (rapid-sequence induction adjunct)
• Adjunct in radiology to speed barium transit
• Off-label: galactagogue

Dosering

Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.

Bijwerkingen

• Common: drowsiness, restlessness, fatigue, diarrhoea
• Extrapyramidal: acute dystonia, akathisia, parkinsonism, tardive dyskinesia (BLACK-BOX)
• Hyperprolactinaemia: galactorrhoea, gynaecomastia, menstrual disturbance
• Rare: neuroleptic malignant syndrome, seizures, methaemoglobinaemia (G6PD-deficient infants)
• Cardiac: bradycardia and hypotension after rapid IV push

Geneesmiddelinteracties

• Anticholinergics, opioids: oppose the prokinetic effect.
• Other dopamine antagonists (haloperidol, risperidone, prochlorperazine): additive extrapyramidal risk — avoid stacking.
• MAO inhibitors: hypertensive crisis — avoid.
• SSRIs, SNRIs: serotonin syndrome (rare).
• Levodopa: each blocks the other's effect — do not co-prescribe.
• Digoxin: gastric-emptying acceleration may reduce digoxin absorption.

Veelgestelde vragen

How is Reglan different from domperidone?

Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.

What does the FDA black-box mean for me?

Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.

Can I take it for travel sickness?

There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.

Is it safe in pregnancy?

Category B in the US. Used in pregnancy for nausea/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.

Can I drive on this?

Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.

What if I develop a stiff neck or strange jaw movements?

Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.

Why do I have leaky breasts on this medication?

Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.

Can it interact with my Parkinson’s drugs?

Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.

Opslag

Below 25°C in a dry place. Keep out of reach of children.

Wat als ik een dosis vergeet?

Take it before the next meal, then continue. Do not double up.

Other Gastro Health Medications

• Dompewal — Domperidone (peripheral D2 antagonist)
• Stemetil — Prochlorperazine (antiemetic)
• Doxinate — Doxylamine + B6 (NVP first-line)
• Omez D — Omeprazole + Domperidone SR
• GR8-OD — Pantoprazole + Domperidone SR
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