Avomine
Avomine (Promethazine theoclate 25 mg) — sedating H1 antihistamine + anticholinergic for motion sickness, vestibular vertigo, and Meniere’s acute attacks.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Avomine?
Avomine bevat promethazine theoclate 25 mg, a first-generation H1 antihistamine with antiemetic, anticholinergic, and sedative properties. It is the established first-line agent for motion sickness, vestibular nausea, en vertigo, and is also used for sedation and as an adjunct in allergy and pregnancy-related nausea (jurisdiction-dependent). Take 30–60 minutes before travel for motion-sickness prophylaxis. Manufactured by Wockhardt under WHO-GMP standards.
📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.
Waarom bestellen bij MedsBase
Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.
When promethazine is the right antiemetic
Promethazine is the go-to drug for motion sickness — sea, air, car, and amusement-park motion. It is also effective for vestibular vertigo (acute labyrinthitis, vestibular neuritis, Meniere’s acute attacks), and as a sedating adjunct in allergic reactions or anxiety-related nausea. It is not first-line for chemotherapy-induced nausea (use ondansetron/granisetron instead) and not first-line for nausea-vomiting of pregnancy in most modern guidelines (NVP first-line is doxylamine+B6 — Doxinate, Pregnidoxin NU). Some jurisdictions still use promethazine for hyperemesis gravidarum after first-line failure.
Waarom bestellen bij MedsBase
Avomine is supplied from a WHO-GMP gecertificeerde fabrikant. Every order ships discreetly worldwide and is covered by our Reshipment Assurance Policy — if it does not arrive within 20 business days, we reship at no cost. Promethazine has been the global standard for motion sickness for decades and remains a useful sedating antiemetic when histaminergic/cholinergic vestibular nausea is the dominant problem.
Werkingsmechanisme
Promethazine is a phenothiazine-derived antihistamine. It blocks H1 histamine receptors (the antihistamine effect that reduces motion-induced vestibular signalling and gives sedation), muscarinic acetylcholine receptors (the anticholinergic effect that further suppresses vestibular and gut motility-driven emesis), and D2 dopamine receptors (a mild antiemetic effect at the chemoreceptor trigger zone). The unique value of promethazine in motion sickness is the combined H1 + anticholinergic blockade — the vestibular system depends on both pathways. The same combined blockade also explains its strong sedative and dry-mouth profile.
Indicaties
- Motion sickness: sea, air, car, train; especially when other agents (cinnarizine, hyoscine patch) have failed or are unavailable.
- Vestibular vertigo: acute labyrinthitis, vestibular neuritis, Meniere’s acute attacks.
- Allergic reactions (urticaria, hay fever) where sedation is helpful or non-sedating antihistamines have failed.
- Pre-medication for anaesthesia (sedation + antiemetic + drying of secretions).
- Slapeloosheid short-term occasional use.
- Hyperemesis gravidarum (jurisdiction-dependent, after first-line doxylamine+B6 failure).
Dosering
| Indicatie | Dosering |
|---|---|
| Motion sickness (adult) | 25 mg the night before, repeat 25 mg morning of travel; or 25 mg 1–2 h pre-travel; max 75 mg/day |
| Vestibular vertigo (adult) | 25 mg every 8–12 h during acute episode; taper after 2–3 days (long-term use slows vestibular compensation) |
| Children 5–10 y | 12.5 mg the night before travel and again the morning of travel |
| Children 2–5 y | Use only if essential under medical supervision; 6.25 mg twice daily maximum |
| Children < 2 y | CONTRAINDICATED — risk of fatal respiratory depression |
| Older adults (> 65) | Use cautiously — high anticholinergic burden; risk of confusion, falls, urinary retention |
Bijwerkingen
- Zeer vaak voorkomend: sedation, dry mouth, blurred vision, urinary hesitancy, constipation
- Vaak voorkomend: dizziness, hypotension on standing, palpitation, mild confusion (especially older adults)
- Minder vaak: photosensitivity, rash, paradoxical excitation in children, extrapyramidal reactions (low frequency vs other phenothiazines)
- Zeldzaam maar ernstig: agranulocytosis, neuroleptic malignant syndrome (very rare), severe respiratory depression in young children, seizures in overdose
Geneesmiddelinteracties
- CNS depressants (alcohol, opioids, benzodiazepines, gabapentinoids, sleep medication): additive sedation and respiratory depression — avoid combination.
- Anticholinergics (TCAs, oxybutynin, atropine, hyoscine patch, antipsychotics): additive dry mouth, urinary retention, cognitive impairment — especially in older adults.
- MAO inhibitors: may prolong and intensify sedation — avoid combination.
- Adrenaline (epinephrine): promethazine may reverse the pressor effect (use noradrenaline if vasopressor needed during anaphylaxis on promethazine).
- Pregnancy test interference: may cause false positive/negative immunological pregnancy tests.
Veelgestelde vragen
How long before travel should I take Avomine?
For best motion-sickness protection, take 25 mg the night before travel and a second 25 mg dose 1–2 hours before departure. Once the journey is underway and you are already nauseated, prevention is much harder — take the dose proactively.
Will Avomine make me sleepy?
Yes — pronounced drowsiness is the dominant side effect. Do not drive, fly an aircraft, scuba dive, or operate machinery for 24 hours after a dose. Many users find this useful for long-haul flights but it is dangerous before active tasks.
Can Avomine be used in pregnancy?
Promethazine has been used historically for hyperemesis gravidarum but is no longer first-line in most modern guidelines. First-line for nausea-vomiting of pregnancy (NVP) is doxylamine + B6 (Doxinate, Pregnidoxin NU); ondansetron, metoclopramide, and promethazine are reserved for refractory cases under specialist supervision.
Can children take Avomine?
Children under 2 years must NOT take promethazine — risk of fatal respiratory depression. For ages 2–5 use only if essential under medical supervision. Standard motion-sickness dosing starts from age 5 with 12.5 mg the night before and morning of travel.
What is the difference between Avomine and ondansetron?
Avomine is a sedating H1 antihistamine + anticholinergic — ideal for motion sickness and vestibular vertigo where the histaminergic and cholinergic pathways are dominant. Ondansetron is a 5-HT3 antagonist — ideal for chemo, radiation, surgery, severe gastroenteritis where the serotonin pathway is dominant. They are not interchangeable.
Is Avomine addictive?
No, promethazine is not a controlled substance and does not cause physical dependence. However, the strong sedation makes it occasionally misused for sleep or to potentiate opioids — the latter is dangerous because of respiratory depression.
Can I drink alcohol with Avomine?
No — combination causes profound sedation and respiratory depression. Avoid alcohol, sleeping pills, and opioids while on promethazine.
Wat als ik een dosis vergeet?
Promethazine is usually used for prevention — take the next dose at the next planned time. If you miss the pre-travel dose, taking it once travel-induced nausea has already started is less effective; an ODT 5-HT3 (Ondem MD) or a cinnarizine alternative may give better breakthrough control.
How does Avomine differ from cinnarizine and meclozine?
All three are anti-vertigo/motion-sickness antihistamines. Cinnarizine has additional calcium-channel blocking action (useful in Meniere’s) and is less sedating. Meclozine is intermediate — less sedating than promethazine, longer-acting than cinnarizine. Promethazine is the most strongly sedating and is preferred when sedation is a benefit (long flights, severe vertigo).
How is Avomine stored?
Store tablets at room temperature (below 25°C), protected from light and moisture. Keep out of reach of children — accidental paediatric ingestion can cause severe respiratory depression.
Other Nausea Treatments
- Stemetil MD (prochlorperazine — vestibular nausea ODT)
- Dompewal (domperidone — gastric-emptying nausea)
- Ondem (ondansetron — chemo/PONV)
- Doxinate (doxylamine + B6 — pregnancy nausea)
- Metopar (paracetamol + metoclopramide — migraine nausea)
- Browse all Nausea Treatments
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Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 25 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Avomine
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