⚡ Quick Answer — What is Fluvoxin?
Fluvoxin obsahuje fluvoxamine, , selective serotonin reuptake inhibitor (SSRI) používaná k léčbě obsessive-compulsive disorder (OCD), depression, panic disorder, a social anxiety disorder. Fluvoxamine is not a respiratory medication — this product is in this category in error. Always discuss SSRI use with a qualified mental health practitioner — fluvoxamine has many drug interactions and gradual dose titration is essential.
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Important — Category Note
What Is Fluvoxin?
Fluvoxin contains fluvoxamine maleate, an SSRI antidepressant. Internationally sold as Faverin and Luvox. Fluvoxamine is the SSRI of choice for OCD in many guidelines because of strong evidence for OCD-specific symptom reduction.
How Does Fluvoxamine Work?
Fluvoxamine selectively inhibits the serotonin transporter (SERT), increasing synaptic serotonin availability. Therapeutic benefit develops over 4–6 weeks of consistent dosing — onset is gradual, not acute.
Použití a indikace
- Obsessive-compulsive disorder (OCD) — first-line SSRI
- Major depressive disorder
- Panic disorder
- Social anxiety disorder
- Post-traumatic stress disorder (PTSD) — adjunct
Fluvoxin Dosage
| Indikace | Počáteční dávka | Target / max |
|---|---|---|
| Adults — OCD / depression | 50 mg once daily | 100–300 mg/day |
| Adults — anxiety | 50 mg once daily | 100–200 mg/day |
| Children >8 yr (OCD) | 25 mg once daily | Up to 200 mg/day |
| Elderly / hepatic impairment | Halve starting dose | Slower titration |
Side Effects of Fluvoxin
- Nausea (commonest, especially in first 1–2 weeks)
- Insomnia or somnolence
- Sexual dysfunction (delayed orgasm, reduced libido)
- Anxiety or agitation in the first 1–2 weeks
- Bolest hlavy
- Weight changes
- Hyponatraemia (rare; particularly in elderly)
Serious — stop and seek help:
- Suicidal ideation, especially in young patients in first weeks
- Závažná alergická reakce
- Serotonin syndrome (high fever, agitation, tremor, clonus — when combined with other serotonergic drugs)
- Severe bleeding (rare; SSRIs slightly raise bleed risk)
Varování a opatření
- Gradual dose escalation is essential — start low, titrate over weeks.
- Monitor for suicidal ideation in first weeks of treatment, especially in young patients.
- Many drug interactions — fluvoxamine is a potent CYP1A2 inhibitor, raising levels of theophylline, caffeine, clozapine, ramelteon, and others. Always tell your prescriber what you take.
- Do not combine with MAOIs (washout 14 days), other serotonergic agents (linezolid, methylene blue), or with pirfenidone (theory: raised pirfenidone levels — though this is the asthma-category context that brought fluvoxamine here).
- Těhotenství a kojení: use only when benefits outweigh risks.
- Discontinuation: taper slowly to avoid withdrawal symptoms.
Kontraindikace
- Concurrent MAOIs
- Concurrent pimozide, thioridazine (QT prolongation)
- Concurrent tizanidine (severe interaction via CYP1A2)
- Concurrent ramelteon (large interaction)
- Hypersensitivity to fluvoxamine
Interakce s léčivy
| Interacting drug | Účinek | Co dělat |
|---|---|---|
| MAOIs (phenelzine, selegiline, linezolid, methylene blue) | Severe serotonin syndrome | Contraindicated; 14-day washout |
| Theophylline (Unicontin-E) | Major CYP1A2 inhibition; toxic theophylline levels | Contraindicated or large dose reduction |
| Pirfenidone (Pirfenex) | 4× increase in pirfenidone exposure | Kontraindikováno |
| Clozapine, olanzapine | Zvýšené hladiny | Caution |
| Tizanidine | Severe hypotension and somnolence | Kontraindikováno |
| Ramelteon | ~190× increase in levels | Kontraindikováno |
| Warfarin | Increased INR | Monitor closely |
| Caffeine | 5× increase in caffeine half-life | Limit caffeine |
Skladování
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Související alternativy na MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Montair — montelukast LTRA tablet
- Tiova Inhaler — tiotropium LAMA for COPD
Často kladené dotazy
Why is Fluvoxin in the asthma category?
It is a categorisation error. Fluvoxin is fluvoxamine, an SSRI for mental health conditions (OCD, depression, anxiety) — not a respiratory medication. We are reviewing this placement.
How long until Fluvoxin works?
OCD and depression: 4–6 weeks for substantial effect; full response can take 8–12 weeks.
Will Fluvoxin help my asthma?
No — fluvoxamine has no direct asthma effect. It is a mental health drug.
Can I take Fluvoxin with my asthma medications?
Caution. Fluvoxamine is a potent CYP1A2 inhibitor — it is contraindicated with theophylline (Unicontin-E) because of toxic level rises, and contraindicated with pirfenidone (Pirfenex) for the same reason. Always tell your prescriber what you take.
Should I stop Fluvoxin suddenly?
No — taper slowly to avoid withdrawal symptoms (dizziness, nausea, irritability, electric-shock sensations). Always under prescriber guidance.
Will Fluvoxin make me suicidal?
SSRIs have a small early risk of suicidal ideation, especially in young patients. Monitor closely in the first weeks; report any concerning thoughts to your prescriber.
Is Fluvoxin safe in pregnancy?
Risks vs benefits assessed by prescriber. Other SSRIs (sertraline) are sometimes preferred in pregnancy.
Can I take Fluvoxin with my SSRI?
No — combining SSRIs is dangerous (serotonin syndrome). Only one SSRI at a time.
Can I drink coffee on Fluvoxin?
Limit caffeine — fluvoxamine raises caffeine half-life ~5×, causing jitteriness, palpitations, insomnia. Switch to decaf or limit to one cup a day.
Související alternativy
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