Naprosyn

What Is Naprosyn?

Naprosyn is a branded generic of naproxen 250 mg, a propionic acid derivative NSAID. Naproxen inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin synthesis. For period pain this matters because dysmenorrhoea is driven by uterine prostaglandins — so NSAIDs are pathophysiologically targeted therapy, not just analgesia. Manufactured by Roche.

Klinické použití

• Primary dysmenorrhoea (period pain): first-line treatment. 500 mg loading then 250 mg every 6–8 hours.
• Heavy menstrual bleeding (menorrhagia): reduces blood loss by ~20–30%.
• Migraine: acute treatment; can be combined with triptans.
• Bolesti pohybového aparátu (back, joint, muscle), rheumatoid arthritis, osteoarthritis.
• Gout attacks (not prophylaxis).

How to Take for Period Pain

1. Start at the first twinge of period pain — or even 1–2 days before if your cycle is predictable. Prostaglandin levels peak early in the period; blocking them early gives much better relief than “chasing” pain.
2. Loading dose: 500 mg (2 tablets), then 250 mg every 6–8 hours as needed, with food or milk.
3. Maximum daily dose: 1000 mg (short-term) or 750 mg (long-term).
4. Continue for 2–3 days — the duration of peak prostaglandin release.
5. Take with food and stay well hydrated.

Vedlejší účinky

Časté: GI upset (nausea, dyspepsia, heartburn), headache, dizziness.

Significant (with prolonged or high-dose use): gastric and duodenal ulcers (consider PPI if long-term or high-risk), GI bleeding, renal impairment, hypertension, fluid retention.

Závažné (vzácné): severe GI bleed or perforation, acute kidney injury, cardiovascular events (NSAID class effect), Stevens-Johnson syndrome, severe allergic reactions.

Who Should Not Take Naprosyn

• Active peptic ulcer or history of NSAID-induced GI bleed
• Severe heart failure, recent coronary bypass surgery
• Severe renal impairment (eGFR <30)
• Known hypersensitivity to NSAIDs (asthma exacerbation, urticaria, angioedema from aspirin or other NSAIDs)
• Third trimester of pregnancy (risk to fetal ductus arteriosus)
• Severe asthma (NSAID-exacerbated respiratory disease)

Interakce s léčivy

• Warfarin, DOACs: increased bleeding risk.
• SSRIs, SNRIs: additive bleeding risk, especially GI.
• ACE inhibitors, ARBs, diuretics: reduced antihypertensive effect; renal impairment risk if combined.
• Methotrexate: raised levels, toxicity risk.
• Lithium: reduced renal clearance; toxicity risk.
• Kortikosteroidy: additive GI ulcer risk.

Skladování

Store at room temperature (15–25 °C). Keep tablets in the blister. Keep out of reach of children.

Často kladené dotazy

When should I start taking naproxen for period pain?

At the first twinge — or even 1–2 days before your period if it is predictable. Starting early gives dramatically better pain control than waiting for pain to build.

How is naproxen different from ibuprofen?

Both are NSAIDs with similar efficacy for period pain. Naproxen has a longer half-life (~12–17 hours) so twice-daily dosing, while ibuprofen is typically 3–4 times daily. Naproxen may have a slightly lower cardiovascular risk signal in long-term use.

Can naproxen reduce bleeding as well as pain?

Yes — naproxen reduces menstrual blood loss by ~20–30%. Tranexamic acid is a specialised non-hormonal option that reduces bleeding more (~40–50%) without affecting pain.

What if naproxen upsets my stomach?

Take with food or milk. Consider adding a PPI (omeprazole, esomeprazole) for short-term use if you have a history of stomach issues. If GI symptoms are severe, switch to another option (paracetamol, tranexamic acid, or hormonal management).

Can I take naproxen while on the contraceptive pill?

Yes — no significant interaction. Naproxen can actually reduce period pain that some COCs don’t fully address.

Can I take naproxen during pregnancy?

Avoid in the third trimester (fetal ductus arteriosus risk). Avoid at time of conception if trying to conceive (may affect implantation). First and second trimesters: discuss with clinician, usually avoided.

What if the pain doesn't respond to naproxen?

Investigate for secondary dysmenorrhoea — endometriosis, adenomyosis, fibroids, PID, ovarian cysts. Persistent severe period pain unresponsive to NSAIDs warrants pelvic ultrasound and gynaecological review.

How long can I take naproxen?

For period pain, 2–3 days per cycle is typical. Chronic daily use requires review — risk of GI bleed, renal impairment, and cardiovascular effects rises with duration. For chronic pain conditions, lowest effective dose with GI protection (PPI) is standard.

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