Epitalon
✅ Supports cellular longevity
✅ Enhances molecular stability
✅ Modulates oxidative stress
✅ Regulates circadian rhythm
✅ Promotes genomic integrity
Epitalon contains synthetic peptide compound.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
Quick Answer — What is Epitalon?
Epitalon (Ala-Glu-Asp-Gly, AEDG) is a synthetic tetrapeptide analog of a natural pineal-gland peptide. Central to Vladimir Khavinson’s Russian longevity-research programme, it is studied for effects on telomere length, circadian rhythm, and gene-expression profiles in aging research. Supplied in 10 mg and 50 mg lyophilized vials for laboratory research use only.
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| Specification | Detail |
|---|---|
| CAS Number | 307297-39-8 |
| Molecular Formula | C14H22N4O9 |
| Molecular Weight | 390.35 Da |
| Sequence | Ala-Glu-Asp-Gly (AEDG) |
| Form | Lyophilized powder (or as supplied) |
| Purity | ≥99% (HPLC verified, COA on request) |
| Storage | Lyophilized: 2–8 °C (refrigerator) for working stock; −20 °C for long-term storage of unopened vials. Reconstituted: 2–8 °C, use within ~30 days. Protect from light. Do not freeze–thaw the reconstituted solution. |
| Solubility | Bacteriostatic water (recommended) or sterile water for shorter use windows |
| Research Use | For laboratory research use only. Not for human or veterinary diagnostic or therapeutic use. |
What Is Epitalon?
Epitalon (also called Epithalon ή AEDG peptide) is a synthetic four-amino-acid peptide: L-Ala-L-Glu-L-Asp-Gly. It is a synthetic analog of a natural pineal-gland peptide called epithalamin, isolated from bovine pineal extract and characterised by Vladimir Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1980s.
Epitalon is one of the most-studied peptides in the Russian longevity-research programme, with published preclinical and small human-cohort research spanning four decades. The research claims — telomerase activation, chromatin remodeling, lifespan extension in model organisms, normalization of melatonin rhythms in older research subjects — are substantial but come from a narrow research group; independent Western replication is limited. Molecular weight approximately 390.4 Da. Supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Epitalon is for laboratory research use only. For deeper mechanism, Khavinson research context, and honest-science summary, see our Epitalon research guide.
Mechanism of Action — Telomerase, Pineal Signaling, Gene Expression
Epitalon’s proposed mechanisms span multiple biological systems. The research is suggestive rather than conclusive on direct mechanism, but three pathways appear consistently in the published literature:
- Telomerase signaling (hypothesized) — Khavinson’s research group published multiple reports of telomere-length elongation in lymphocytes and fibroblasts following Epitalon administration, attributed to telomerase activation. Whether Epitalon directly activates telomerase or does so indirectly via gene-expression modulation remains unresolved. Western replication of the telomere observation is limited.
- Pineal-gland and melatonin rhythm — Epitalon is an analog of a pineal-derived peptide and multiple studies describe restoration of age-disrupted melatonin circadian rhythms. The pineal-peptide origin is the mechanistic anchor for sleep-architecture and circadian research context.
- Gene expression modulation — expression profiling studies in Khavinson’s group describe modulation of approximately 300 rodent genes, with effects on stress-response, antioxidant-defense, and aging-marker pathways. This is the most mechanistically plausible pathway for broader anti-aging research observations.
The broader research framework is that pineal-derived peptides regulate age-related system-level biology — sleep, hormonal rhythm, antioxidant defense — that collectively influence lifespan. Whether this framework holds up against rigorous Western-standard replication remains an open research question.
Published Research Applications
Epitalon is used in laboratory research contexts that investigate:
- Telomere-length research — lymphocyte and fibroblast telomere research in cellular-aging models (Khavinson et al., Neuro Endocrinol Lett 2002; Anisimov et al., Biogerontology 2003)
- Aging research — cellular-aging markers, stress-response, and lifespan in rodent longevity research models
- Melatonin and circadian research — pineal function and sleep-phase research in aging models
- Sleep architecture — slow-wave and REM sleep research in older rodent models
- Eye-health research — retinal and optic-nerve research in age-related degeneration models
- NAD+ stacking — paired with NAD+ in longevity research protocols for complementary cellular-aging pathway coverage
- Longevity stacking — paired with Semax in cognitive-aging research and with GHK-Cu in broader anti-aging research
For broader context on longevity peptide research, see the research peptides catalog.
Available Strengths and Concentrations
MedsBase stocks Epitalon in the following lyophilized vial sizes:
| Vial Strength | Typical Use Case | Pack Sizes |
|---|---|---|
| 10 mg | Standard research strength — supports a single 10-day cycle at 5 mg + leftover | 10, 20, or 30 vials |
| 50 mg | Extended research protocols, multiple cycles per vial, lowest per-mg cost | 10, 20, or 30 vials |
Epitalon research protocols typically use cyclical dosing (10–20 day active periods 1–2 times per year) rather than continuous administration. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.
How It Compares — Epitalon vs Other Longevity Peptides
Epitalon sits within a small longevity-peptide research space. Key comparators:
| Criterion | Epitalon | NAD+ | SS-31 (Elamipretide) |
|---|---|---|---|
| Primary mechanism | Telomerase / pineal signaling | Sirtuin / PARP coenzyme | Mitochondrial cardiolipin binding |
| Research-evidence strength | Narrow group (Khavinson), limited Western replication | Well-characterised biochemistry, many labs | Multiple human trials, Szeto-Schiller lab |
| Regulatory status | Not approved anywhere | Not approved (IV therapy use common) | FDA orphan-drug, Phase 3 |
| Typical research dose | 5–10 mg SC daily, 10–20 day cycles | 50–100 mg daily | 5–40 mg SC daily |
Researchers often use Epitalon alongside NAD+ και SS-31 (Elamipretide) in multi-pathway longevity research protocols.
Storage and Reconstitution
Before reconstitution: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.
Reconstitution procedure: inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently — do δεν shake — and allow 5–10 minutes for full dissolution. Solution should be clear and colourless.
After reconstitution: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution.
Συχνές Ερωτήσεις
What is Epitalon used for in research?
Epitalon is used in laboratory research investigating telomere-length biology, cellular-aging biomarkers, melatonin and circadian rhythm research, sleep architecture, eye-health research, and multi-pathway longevity research protocols stacked with other compounds. It is δεν FDA-approved and is sold here strictly for laboratory research use only.
Does Epitalon really activate telomerase?
Khavinson’s Russian research group has published multiple studies reporting telomere-length elongation in lymphocytes and fibroblasts following Epitalon. The proposed mechanism is telomerase activation. Independent Western replication of these telomere observations is limited, so researchers should treat the telomerase-activation claim as a working hypothesis rather than established mechanism.
What is the typical Epitalon research dose?
Published preclinical and small-cohort research protocols typically use 5–10 mg SC daily, administered in cyclical 10–20 day blocks 1–2 times per year rather than continuous administration. A 10 mg vial reconstituted with 1.0 mL bacteriostatic water yields 10 mg/mL — 50 ticks on a U-100 syringe delivers 5 mg.
Is Epitalon FDA approved?
No. Epitalon has not received FDA, EMA, or any regulatory approval. It is available in Russia as Epithalon / Endoluten (a pineal-extract product) but not specifically as the AEDG synthetic peptide. All Epitalon sold by research-use-only suppliers is for laboratory investigation.
Who is Vladimir Khavinson and why is he cited everywhere?
Vladimir Khavinson is a Russian researcher at the St. Petersburg Institute of Bioregulation and Gerontology who has led the long-running Epitalon and bioregulatory-peptide research programme. Most of the published Epitalon research originates from his group, which is both the source of deep research history on the compound and the reason independent Western replication is limited.
How should Epitalon be stored?
Lyophilized vials: refrigerated at 2–8 °C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2–8 °C, use within 30 days. Do not freeze reconstituted solution.
How do I reconstitute Epitalon?
Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do δεν shake.
Can Epitalon be stacked with other peptides in research?
Yes. Epitalon is commonly paired with NAD+, SS-31, and Semax in multi-pathway longevity and cognitive-aging research protocols. Each acts via a distinct mechanism, so combined protocols target broader aspects of cellular-aging biology.
What strengths does MedsBase stock?
MedsBase carries Epitalon in 10 mg and 50 mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.
Does Epitalon cause side effects in research?
Published research reports a clean safety profile at typical research doses. No significant off-target signals have been identified. Because Epitalon is a small (four amino-acid) peptide with limited systemic exposure, pharmacological concerns are lower than for many peptides — but long-term human safety data remain limited.
What is the half-life of Epitalon?
Epitalon (Ala-Glu-Asp-Gly) is a short tetrapeptide with a rapid plasma half-life estimated at under 30 minutes, consistent with small unmodified peptides. Despite rapid clearance, multiple preclinical and human longevity studies by the original researchers (Khavinson et al.) used intermittent administration cycles — typically 10–20 day courses — with reported effects on telomerase activity and biomarkers persisting between cycles.
How does Epitalon activate telomerase in research?
Epitalon is proposed to stimulate telomerase activity by upregulating hTERT (human telomerase reverse transcriptase) gene expression in somatic cells. In vitro studies and rodent longevity models have shown extended telomere length and increased telomerase activity in treated cells. The mechanism is believed to involve interaction with the pineal gland and downstream neuroendocrine regulation, though direct molecular details remain an active area of research.
Can I order Epitalon for international shipping?
Yes. MedsBase ships Epitalon worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.
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- CJC-1295 with DAC — GHRH analog with extended half-life
- GHK-Cu — Copper peptide — skin and connective tissue regeneration research
Further Reading
📖 Learn the research behind this peptide
Read our complete evidence-based guide: Epitalon — telomerase, longevity & the honest science. Covers pineal-peptide origin, Khavinson’s research programme, telomere-length research, cyclical dosing protocols, and realistic research expectations.
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| Ισχύς | 10 mg, 50 mg |
|---|---|
| Ποσότητα | 10 Vials, 20 Vials, 30 Vials |
Epitalon
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