CJC-1295 ilman DAC:ia

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What Is CJC-1295 without DAC?

CJC-1295 ilman DAC:ia (commonly called Mod GRF 1-29 or simply tetrasubstituted GRF 1-29) is a synthetic 30-amino-acid analog of growth-hormone-releasing hormone. It shares the same core peptide sequence as CJC-1295 DAC:lla — four amino-acid substitutions on the native GHRH (1-29) sequence provide resistance to DPP-IV cleavage — but lacks the albumin-binding DAC modification that extends half-life in the “with DAC” version.

The practical consequence of no DAC: plasma half-life remains in the minutes-to-hours range (~30 minutes) rather than days. Research protocols therefore use multiple daily injections (typically 2–3x) to maintain GHRH signal rather than the weekly dosing of the DAC version. This mimics the short, pulsatile profile of endogenous GHRH and is the preferred research tool when pulse-timing matters — particularly in protocols studying physiological GH pulsatility alongside ghrelin-receptor agonists such as ipamorelin.

Molecular weight approximately 3,367 Da. Supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. CJC-1295 without DAC is vain laboratoriotutkimuskäyttöön and is not intended for human or veterinary diagnosis or therapy. For mechanism, research context, and stacking protocols, see our Ipamorelin & CJC-1295 research guide.

Mechanism of Action — Pulsatile GHRH Signaling

Mod GRF 1-29 acts through the same pituitary GHRH receptor pathway as native GHRH, but with a kinetic profile that distinguishes it from both native GHRH and the DAC version:

• GHRH receptor agonism — CJC-1295 without DAC binds GHRH receptors on pituitary somatotropes, stimulating growth-hormone synthesis and release. The amino-acid substitutions resist DPP-IV degradation, giving longer activity than native GHRH (which lasts only a few minutes) but still within the short-half-life range of 30 minutes.
• Short, pulsatile kinetics — because there is no albumin tether, plasma levels rise and fall on a timescale matching the body’s natural GH pulse architecture. This is the critical mechanistic distinction from the DAC version, which produces a sustained non-pulsatile elevation.
• GHRP synergy via parallel receptor — co-administration with a growth-hormone-releasing peptide such as ipamorelin (acting on the parallel ghrelin-receptor pathway) produces GH pulses substantially larger than either compound alone. The short-half-life version is often preferred for this stacking research because both peptides can be timed together for same-pulse amplification.

The research implication: Mod GRF 1-29 is the tool of choice when the research question involves physiological pulsatile GH signaling. The DAC version is preferred when the question involves sustained GH/IGF-1 elevation. Same peptide family; fundamentally different pharmacokinetics.

Julkaistut tutkimussovellukset

CJC-1295 without DAC is used in laboratory research contexts that investigate:

• Pulsatile GH release — physiological GH-pulse research matching native GHRH kinetics
• Ipamorelin stacking — the canonical GHRH + GHRP research combination, often using the short-half-life variant for same-pulse timing
• Body composition research — lean-mass, IGF-1 response, and body-composition research in pulsatile GH-axis modulation studies
• Sleep architecture — pre-sleep dosing aligned with endogenous nocturnal GH-surge research
• Recovery research — skeletal-muscle recovery protocols combined with BPC-157 ja TB-500 for connective-tissue and muscle research
• Comparative kinetic research — side-by-side with CJC-1295 DAC:lla to isolate the albumin-tether effect on GH-axis signaling
• GHRH analog comparisons — alongside sermorelin ja tesamorelin for cross-analog pharmacology research

For broader context on GH-axis peptides see the tutkimuspeptidien luettelo.

Saatavat vahvuudet ja pitoisuudet

MedsBase stocks CJC-1295 without DAC in the following lyophilized vial sizes:

Because Mod GRF 1-29 is typically dosed 2–3x daily at 100–200 mcg per administration, a 5 mg vial supports 2–3 weeks of research use. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.

How It Compares — CJC-1295 without DAC vs With DAC vs Ipamorelin

The three GH-axis peptides differ significantly in receptor, half-life, and stacking characteristics:

Full protocol comparison in our Ipamorelin + CJC-1295 research guide.

Säilytys ja liuotus

Ennen liuotusta: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.

Uudelleenliuotusmenettely: inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently — do ei shake — and allow 5–10 minutes for full dissolution. Solution should be clear and colourless.

Uudelleenliuotuksen jälkeen: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution.

Usein Kysytyt Kysymykset

What is CJC-1295 without DAC used for in research?

CJC-1295 without DAC (Mod GRF 1-29) is used in laboratory research investigating pulsatile growth-hormone release, GHRH-receptor pharmacology, IGF-1 response kinetics, sleep architecture, body composition, and synergistic stacking with GHRP peptides such as ipamorelin. It is ei FDA-approved and is sold here strictly for laboratory research use only.

What is the difference between CJC-1295 with and without DAC?

Both versions share the same core modified GHRH (1-29) sequence. The “with DAC” version has a maleimide group that binds covalently to serum albumin, extending plasma half-life from ~30 minutes to ~7 days. The “without DAC” version lacks this tether and retains the short half-life needed for pulsatile-research protocols. Choice depends on whether the research question requires sustained or pulsatile GHRH signaling.

What is the typical research dose?

Published preclinical protocols typically use 100–200 mcg per administration, 2–3 times daily. A 5 mg vial reconstituted with 2.0 mL bacteriostatic water yields 2.5 mg/mL — 4 ticks on a U-100 syringe delivers 100 mcg.

Is CJC-1295 without DAC FDA approved?

No. Neither the with-DAC nor without-DAC version of CJC-1295 has received FDA, EMA, or any regulatory approval. Original development by ConjuChem was discontinued. All CJC-1295 sold by research-use-only suppliers is for laboratory investigation only.

Why would I choose “without DAC” over “with DAC” in research?

“Without DAC” is preferred when the research question involves pulsatile physiological GH signaling, same-pulse ipamorelin stacking (both peptides timed together), or sleep-architecture research where pre-sleep dosing needs to align with the natural nocturnal GH surge. “With DAC” is preferred for sustained-IGF-1 elevation research and simpler weekly dosing.

How should CJC-1295 without DAC be stored?

Lyophilized vials: refrigerated at 2–8 °C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2–8 °C, use within 30 days. Do not freeze reconstituted solution.

How do I reconstitute CJC-1295 without DAC?

Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do ei shake.

Should I stack CJC-1295 without DAC with ipamorelin?

Yes — this is the canonical GH-axis research stack for pulsatile-signaling research. Both peptides are typically dosed together 2–3x daily; the short half-lives of both align so that each administration produces a same-pulse synergistic GH release. See our stack research guide.

Mitä vahvuuksia MedsBase pitää varastossaan?

MedsBase carries CJC-1295 without DAC in 2 mg, 5 mg, and 10 mg lyophilized vials. Each strength is available in 10-vial or 20-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.

Does CJC-1295 without DAC cause side effects in research?

Published preclinical research has reported a reasonable safety profile at typical research doses. The most commonly reported observation is transient injection-site redness. Long-term human safety data are not available. Because the pulsatile kinetics are closer to native GHRH than the DAC version, some researchers consider this form more physiologically consistent.

What is the half-life of CJC-1295 Without DAC?

CJC-1295 without DAC (Modified GRF(1-29)) has a plasma half-life of approximately 30 minutes — extended from native GHRH(1-29)’s ~7 minutes by four amino acid substitutions that protect against enzymatic degradation. This moderate half-life produces a pulsatile GH release pattern, making it more physiologically similar to endogenous GHRH signalling than the longer-acting DAC form.

Why choose CJC-1295 Without DAC over the DAC version?

CJC-1295 without DAC preserves a pulsatile GH secretion pattern similar to endogenous GHRH physiology. Research protocols prioritising physiological pulsatility — particularly when stacking with a GHRP like Ipamorelin — typically use the no-DAC form. The DAC version is favoured in research requiring maximal GH area-under-the-curve with less frequent administration.

Can I order CJC-1295 without DAC for international shipping?

Yes. MedsBase ships CJC-1295 without DAC worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.

Muut peptidit toipumis- ja suorituskykytutkimukseen

• BPC-157 — Body Protection Compound — jänteiden, nivelsiteiden ja suoliston toipumistutkimus
• TB-500 — Thymosin Beta-4 fragmentti — pehmytkudosten ja verisuonten toipumistutkimus
• Ipamorelin — Selektiivinen ghreliniagonisti — puhdas GH-pulssi ilman kortisolia/prolaktiinia
• CJC-1295 DAC:lla — GHRH-analogia pidennettyä puoliintumisaikaa
• GHK-Cu — Kuparipeptidi — ihon ja sidekudosten uusiutumistutkimus

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