Acnetoin
✅ Treats severe acne
✅ Vermindert huidontsteking
✅ Unclogs skin pores
✅ Promotes skin renewal
✅ Minimizes acne scars
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
💡 Quick Answer — What is Acnetoin?
Acnetoin contains azithromycin 250 mg / 500 mg (oral) — an oral macrolide antibiotic for moderate-to-severe inflammatory acne vulgaris (off-label) and respiratory/skin/ENT bacterial infections. Acne (off-label): pulse therapy 500 mg once daily for 3 days per week for 8–12 weeks. Bacterial infection: 500 mg once daily for 3 days. Take on empty stomach (1 hour before / 2 hours after food). For acne, azithromycin is reserved when doxycycline (the standard oral antibiotic for acne) is contraindicated — pregnancy, doxycycline allergy, photosensitivity intolerance.
📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.
Waarom bestellen bij MedsBase
Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.
Waarom bestellen bij MedsBase
Choosing Acnetoin from MedsBase:
- WHO-GMP gecertificeerde fabrikant — afkomstig uit een gereguleerde faciliteit, complete verpakking met batchnummer en vervaldatum.
- Discrete verpakking — gewone envelop, geen medicatienaam aan de buitenkant.
- Wereldwijde verzending met Reshipment Assurance — if your parcel does not arrive within 20 business days we re-ship at no cost (subject to policy terms).
- Loyaliteitspunten — 1 point per $1 spent (excludes peptides); 100 points = $5 off.
What Acnetoin is and how it works
Acnetoin contains azithromycin 250 mg / 500 mg (oral). Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis at the 50S ribosome. It accumulates in tissue and inflammatory cells, giving it a long tissue half-life (~3 days) and enabling pulse-dose regimens. In acne, it works through both antibacterial activity against Cutibacterium acnes and intrinsic anti-inflammatory effects on cytokine release. Manufacturer: WHO-GMP certified manufacturer.
Indicaties
- Moderate-to-severe inflammatory acne — off-label, pulse therapy.
- Acute bacterial sinusitis, otitis media, pharyngitis — first-line in macrolide-susceptible infections.
- Community-acquired pneumonia — atypical pathogen coverage.
- Huid- en weke delen infecties — Strep, Staph, Cutibacterium.
- Sexually transmitted infections — chlamydia, gonorrhoea (combination therapy), Mycoplasma genitalium.
Dosing for acne (off-label)
| Regime | Dosering |
|---|---|
| Pulse (most common) | 500 mg once daily × 3 days per week for 8–12 weeks |
| Continuous (less common) | 250 mg daily × 4 weeks then taper |
| Bacterial infection | 500 mg once daily × 3 days (Z-Pak equivalent) |
⚠️ Cardiac safety — QT prolongation — Azithromycin can prolong the QT interval and rare cases of torsades de pointes have been reported, especially in patients with: long QT syndrome, hypokalaemia or hypomagnesaemia, concurrent QT-prolonging drugs (other macrolides, fluoroquinolones, antipsychotics, antiarrhythmics), and the elderly. The 2013 FDA azithromycin black-box advisory addresses this. Avoid in known QT-prolonging conditions; review medication list before starting.
Bijwerkingen
- Vaak voorkomend: nausea, abdominal pain, diarrhoea (sometimes severe), headache.
- Minder vaak: rash, transaminitis, taste disturbance.
- Zeldzaam maar ernstig: hepatotoxicity (cholestatic), pseudomembranous colitis (C. difficile), severe cutaneous adverse reactions (Stevens-Johnson, TEN), QT prolongation.
Contra-indicaties
- Hypersensitivity to azithromycin, erythromycin, or any macrolide.
- Long QT syndrome (congenital or acquired).
- History of cholestatic jaundice with prior macrolide use.
- Severe hepatic impairment.
Geneesmiddelinteracties
- QT-verlengende geneesmiddelen: additive risk — avoid combination with quinolones, antipsychotics, methadone, ondansetron.
- Warfarine: azithromycin can increase INR — monitor.
- Statins: minimal interaction with azithromycin (unlike clarithromycin or erythromycin).
- Digoxin: azithromycin can raise digoxin levels — monitor in patients with renal impairment.
- Antacids (Al/Mg): reduce azithromycin absorption — separate by 2 hours.
Zwangerschap & borstvoeding
Azithromycin is FDA Category B — generally considered safe during pregnancy when needed. It is excreted in breast milk in low concentrations; use with caution in breastfeeding.
Opslag
Store below 25 °C in the original blister. Keep dry.
Veelgestelde vragen
Why use azithromycin for acne instead of doxycycline?
Doxycycline is the standard. Azithromycin is reserved when doxycycline is contraindicated: pregnancy (doxycycline contraindicated after 18 weeks gestation), doxycycline allergy, severe photosensitivity intolerance, or compliance issues (azithromycin pulse is fewer doses).
Hoelang duurt het voordat ik resultaten zie?
4–6 weeks for visible reduction in inflammatory lesions; 12 weeks for full effect. Combine with topical retinoid + BPO for best outcomes.
What is “pulse therapy”?
Taking the antibiotic for 3 days per week with 4-day rest, exploiting azithromycin’s long tissue half-life (~3 days). Reduces total exposure, side effects, and resistance development compared to daily dosing.
Why must I take it on an empty stomach?
Food reduces azithromycin absorption by up to 50%. Take 1 hour before or 2 hours after meals for full bioavailability. Antacids reduce absorption — separate by 2 hours.
Is the QT warning serious?
Real but rare. Risk is meaningful in patients with: existing long QT, severe electrolyte imbalance, or concurrent other QT-prolonging drug. For otherwise healthy patients, the absolute risk is very low.
Can I take Acnetoin for a sore throat?
For confirmed bacterial pharyngitis (group A strep), yes — though penicillin/amoxicillin is preferred. Most sore throats are viral and do not need antibiotics.
What about C. difficile?
Azithromycin can disrupt gut flora and predispose to C. difficile colitis. If severe diarrhoea develops during or after treatment, stop and seek medical advice.
Will I develop antibiotic resistance?
Macrolide resistance in C. acnes is common with prolonged courses. Use azithromycin in combination with topical BPO and topical retinoid to reduce resistance development. Limit oral antibiotic courses to 12 weeks.
Can I drink alcohol while taking Acnetoin?
Moderate alcohol is acceptable but increases nausea and gastrointestinal upset risk. Both are processed by the liver — heavy alcohol use during macrolide courses increases hepatotoxicity risk.
Is Acnetoin the same as Z-Pak?
Yes — Z-Pak is the US 6-tablet pack of azithromycin (500 mg day 1, then 250 mg daily ×4). Acnetoin is a generic equivalent at the same molecule and strength.
Other Beauty & Skin Care Medications
- Melalite Forte Cream — hydroquinone 4% for melasma
- Retino-A Cream — tretinoin for acne and ageing
- Melacare Cream — Kligman triple for melasma
- Permite Cream — permethrin 5% for scabies
- Tenovate Cream — clobetasol 0.05% for severe inflammation
Medisch disclaimer. This content is for general information about the product and is not medical advice or a substitute for advice from a qualified healthcare professional. Use any topical or oral medication only under appropriate medical supervision; misuse can cause serious harm.
More options in Beauty & Skin Care
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 20 mg |
|---|---|
| Hoeveelheid | 30 Capsule/s, 60 Capsule/s, 90 Capsule/s |
| Farmaceutische vorm | Zachte gelatinecapsules |
| Fabrikant | Leeford Pharma |
| Behandeling | BEAUTY & SKIN CARE |
| Generiek merk | Adapalene |
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