Cetil
✅ Enhances Immune System
✅ Promotes Healthy Skin
✅ Boosts Energy Levels
✅ Supports Heart Health
✅ Improves Digestive Function
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Cetil?
Cetil is a cefuroxime axetil tablet (250 mg / 500 mg, Cipla) — a second-generation oral cephalosporin. It covers respiratory pathogens (S. pneumoniae, H. influenzae, M. catarrhalis) and is used for sinusitis, otitis media, bronchitis, and Lyme disease.
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How Cetil works
Cetil contains Cefuroxime axetil, a second-generation cephalosporin with extended Gram-negative cover (H. influenzae, Moraxella catarrhalis, Neisseria spp.) while retaining respectable Gram-positive activity. It is bactericidal via cell-wall inhibition. Resistance arises through extended-spectrum beta-lactamases (ESBLs), AmpC, and reduced porin permeability — none of these cephalosporins should be used empirically when ESBL/AmpC organisms are likely.
Indications & dosing
| Indicatie | Standaarddosering | Duur |
|---|---|---|
| Acute bacterial sinusitis / otitis media | 250–500 mg twice daily | 5–10 days |
| Acute bronchitis / bacterial exacerbation of COPD | 500 mg twice daily | 5–10 days |
| Lyme disease (early localised, alternative to doxycycline / amoxicillin) | 500 mg twice daily | 14 days |
| Skin / soft-tissue infection | 250–500 mg twice daily | 7–10 days |
Renal dose adjustment: all oral cephalosporins require dose extension below CrCl 30 — confirm with a clinical pharmacist for severe renal impairment. Ceftriaxone (which is biliary-excreted) does NOT need renal adjustment.
Bijwerkingen
- Maag-darm: nausea, diarrhoea (5–10%); higher with cefixime and cefpodoxime than with cephalexin.
- Overgevoeligheid: 5–10% cross-reactivity with penicillin allergies (lower than once thought; ~0–2% with non-anaphylactic penicillin reactions).
- Clostridioides difficile colitis: elevated risk versus narrow-spectrum agents — broad cephalosporins are the second-most C. difficile-driving class after fluoroquinolones.
- Haematological: rarely eosinophilia, thrombocytosis, neutropenia.
- Nierfunctie: rare interstitial nephritis; dose-dependent rises in serum creatinine reported with high-dose IV cephalosporins.
- Ceftriaxone-specific: biliary pseudolithiasis (gallbladder sludge) — usually asymptomatic, reverses on stopping.
Contra-indicaties
- Previous IgE-mediated cephalosporin allergy.
- Anaphylactic-class penicillin allergy without skin-test clearance.
- Severe renal impairment without dose adjustment (oral cephalosporins).
- Neonates with hyperbilirubinaemia — ceftriaxone displaces bilirubin from albumin (kernicterus risk).
Geneesmiddelinteracties
| Geneesmiddel | Effect | Action |
|---|---|---|
| Warfarine | Slight INR rise (especially with N-methylthiotetrazole-side-chain cephalosporins) | Check INR mid-course |
| Calcium IV (neonates) | Lethal precipitation with ceftriaxone | Absolute contraindication ≤ 28 days |
| Probenecide | Raises serum levels (oral cephalosporins) | No routine adjustment |
| Antacids / H2 blockers | Reduces absorption of cefpodoxime | Separate by 2 hours |
| Aminoglycosides | Possible additive nephrotoxicity (high-dose IV) | Monitor renal function |
Pregnancy & Breastfeeding
Cephalosporins are FDA category B — extensively used in pregnancy without evidence of fetal harm. They are first-line alternatives in penicillin-allergic patients without an anaphylactic history.
Opslag
Store below 25 °C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date — degraded antibiotics can lose potency or release breakdown products.
This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE — the WHO ranks antimicrobial resistance among the top 10 global public-health threats.
Veelgestelde vragen
Can I take Cetil if I am allergic to penicillin?
It depends on the type of penicillin reaction. If you had anaphylaxis, severe urticaria, angioedema, or Stevens–Johnson syndrome — avoid all beta-lactams without specialist clearance. If your reaction was a mild delayed rash, modern allergy guidance considers cephalosporin use generally safe — discuss with your prescriber.
Why do cephalosporins cause more diarrhoea than penicillins?
Cephalosporins disturb anaerobic gut flora more aggressively, particularly when poorly absorbed (cefixime is ~50% absorbed; cefpodoxime ~40%). This raises C. difficile colonisation pressure. Stop and seek review for new watery diarrhoea, especially with fever or abdominal pain.
How quickly should I feel better?
Most uncomplicated infections improve within 48–72 hours. If you are no better by day 3 — or worse — seek review. The pathogen may be resistant or the diagnosis incorrect.
Mag ik alcohol drinken?
Most cephalosporins do not produce a disulfiram-like reaction. (Older agents like cefamandole and cefoperazone did — these are not used here.) Moderate alcohol is fine; binge drinking weakens immune response.
Should I take it with food?
Cephalexin and cefadroxil are absorbed equally with or without food. Cefpodoxime absorption is increased ~50% by food and decreased by acid suppressants — take it WITH a meal and separate from antacids by 2 hours.
Wat als ik een dosis vergeet?
Take it as soon as you remember. If close to the next scheduled dose, skip the missed one and resume. Never double up.
Can I use Cetil for a viral cold?
No — cephalosporins are bactericidal and have no activity against viruses. Inappropriate use accelerates resistance and disturbs your gut and respiratory flora. Use only for confirmed bacterial infections.
Will Cetil cover Pseudomonas?
No — only ceftazidime and cefepime among cephalosporins have reliable Pseudomonas activity, and neither is used here. Cefuroxime axetil should not be used empirically when Pseudomonas is suspected.
Will it interact with my warfarin?
Yes — INR may rise. Check INR 3–5 days into therapy and counsel on bleeding signs. Adjust warfarin dose only on physician advice.
Are cephalosporins safe in breastfeeding?
Yes — milk transfer is minimal. WHO and AAP rate cephalosporins as compatible with breastfeeding. Watch the infant for thrush or diarrhoea, but no maternal dose change is needed.
Other Antibiotics & Anti-Infective Medications
- Augmentin (Amoxicillin + Clavulanic acid) — beta-lactam alternative
- Azee (Azithromycin) — atypical-pathogen cover
- Levomac (Levofloxacin) — respiratory fluoroquinolone
- Doxt (Doxycycline) — atypical pneumonia / STIs
- Mox (Amoxicillin) — first-line for many community infections
More options in Antibiotics
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 250 mg, 500 mg |
|---|---|
| Hoeveelheid | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s |
| Farmaceutische vorm | Tablet/s |
| Fabrikant | Lupin Ltd |
| Behandeling | Bacteriële infecties |
| Generiek merk | Cefuroxime |
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