Deplatt

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What Is Deplatt?

Deplatt is 75 mg clopidogrel tablets from Torrent Pharma, supplied in 30-90 tablets. Clopidogrel was approved by the FDA in 1997 and is the most widely used P2Y12 inhibitor worldwide. Landmark trials — CAPRIE (1996, secondary prevention vs aspirin), CURE (2001, ACS without ST elevation), CLARITY/COMMIT (2005, STEMI) and PCI-CURE — established its role in atherothrombotic disease.

How Clopidogrel Works

Clopidogrel is a prodrug that requires two-step hepatic activation by CYP2C19 (and to a lesser extent CYP3A4, CYP1A2, CYP2B6) to its active thiol metabolite. The active metabolite irreversibly binds the platelet P2Y12 receptor, blocking ADP-mediated platelet activation and aggregation. Inhibition lasts the lifespan of the affected platelet (7-10 days), so platelet function recovers gradually as new platelets are produced.

Goedgekeurde Toepassingen

• Acute coronary syndrome (ACS) — with aspirin (DAPT) for non-ST-elevation ACS and ST-elevation MI (CURE, CLARITY, COMMIT)
• Post-percutaneous coronary intervention (PCI) — DAPT for 6-12 months after stenting (longer for some drug-eluting stents in high-risk patients)
• Secondary prevention after ischaemic stroke or TIA — monotherapy or short-term combination with aspirin (CHANCE, POINT)
• Established peripheral arterial disease — reduces MI, stroke and vascular death (CAPRIE)
• Aspirin-intolerant secondary prevention — alternative monotherapy for atherothrombotic event prevention

Dosering

Onderhoudsdosis: 75 mg once daily, with or without food. ACS / PCI loading: 300 mg (often 600 mg in primary PCI) loading dose followed by 75 mg daily. Stroke/TIA: 75 mg daily as monotherapy; short-course 21-day DAPT with aspirin in minor stroke/high-risk TIA per CHANCE/POINT then continue clopidogrel monotherapy. Duration of DAPT after stenting is determined by the cardiologist based on stent type, indication and bleeding risk.

CYP2C19 Genetic Variation

Around 30% of East Asians and 2-15% of Caucasians carry CYP2C19 loss-of-function alleles (*2, *3) that reduce clopidogrel activation and increase ischaemic event rates after PCI. Where genotyping or platelet-function testing identifies poor or intermediate metabolisers, alternative P2Y12 inhibitors (ticagrelor, prasugrel) are typically preferred.

Bloedingsrisico en monitoring

Major bleeding rate is roughly 1-3%/year on monotherapy and higher on DAPT. No routine blood test is needed for efficacy. Monitor for bruising, epistaxis, gum bleeding, GI bleeding (melaena, haematemesis, fresh rectal blood), haematuria, or unusually heavy menstrual bleeding. Baseline FBC, renal and hepatic function are sensible. Co-prescribed PPI (preferably pantoprazole or rabeprazole) is recommended in patients at increased GI bleeding risk.

Bijwerkingen

• Bruising and minor bleeding (epistaxis, gum bleeding)
• GI bleeding (peptic ulcer, gastritis)
• Diarrhoea, dyspepsia, abdominal pain
• Rash and pruritus
• Thrombocytopenia (rare)
• Thrombotic thrombocytopenic purpura (TTP) — rare but life-threatening; presents within first 2 weeks
• Hepatic enzyme elevation

Contra-indicaties

• Active pathological bleeding (peptic ulcer, intracranial haemorrhage)
• Hypersensitivity to clopidogrel or any thienopyridine
• Ernstige leverfunctiestoornis
• Borstvoeding

Geneesmiddelinteracties

• Strong CYP2C19 inhibitors (omeprazole, esomeprazole) — reduce clopidogrel activation; prefer pantoprazole or rabeprazole when a PPI is needed.
• Other antiplatelets and anticoagulants (aspirin, NSAIDs, warfarin, DOACs, heparins) — additive bleeding risk; combine only when clinically indicated under specialist supervision.
• SSRIs/SNRIs — reduce platelet serotonin uptake; modest additive bleeding risk.
• Repaglinide — clopidogrel inhibits CYP2C8; markedly raises repaglinide levels and hypoglycaemia risk.
• Sterke CYP3A4-induceerders (rifampicin) — may increase active metabolite formation but data inconsistent.

Surgery and Dental Procedures

Stop clopidogrel 5-7 days before elective surgery with significant bleeding risk. Most simple dental work can be done without stopping. Never stop clopidogrel within the protected DAPT window after coronary stenting without cardiology advice — premature discontinuation is a major cause of in-stent thrombosis and MI.

Pregnancy and Breastfeeding

Pregnancy: limited human data. Use only when benefit clearly outweighs risk; specialist input required. Breastfeeding: avoid — transfer to milk likely.

Opslag

Store Deplatt below 25°C in the original blister pack. Keep out of reach of children.

Veelgestelde vragen

Do I need blood tests on Deplatt?

No routine test is needed for efficacy. Baseline FBC, renal and hepatic function are sensible. Genotyping or platelet-function testing is reserved for select cardiology cases.

Can I take Deplatt with aspirin?

Yes — the clopidogrel + aspirin combination (DAPT) is the standard regimen for 6-12 months after acute coronary syndrome or coronary stenting. Duration is set by your cardiologist.

What if I miss a dose of Deplatt?

If you remember within 12 hours, take the missed dose. Otherwise skip and resume the next day — do not double up.

What should I do if I cut myself or bruise easily?

Apply firm direct pressure for 15-20 minutes for cuts. Bruising is common. Bleeding that continues >20 minutes or bleeds through dressings, black stools, blood in urine, or unexplained heavy menstrual bleeding warrants urgent medical review.

Can I take Deplatt with omeprazole?

Omeprazole and esomeprazole reduce clopidogrel activation and are best avoided. If a PPI is needed for stomach protection, pantoprazole or rabeprazole are preferred.

Wat als ik een operatie nodig heb?

Inform your surgeon and cardiologist well in advance. Clopidogrel is typically stopped 5-7 days before elective procedures with significant bleeding risk — but never stop without cardiology input if you have a recent coronary stent.

Is Deplatt the same as Plavix?

Both contain the same active ingredient, clopidogrel 75 mg. Brand-name Plavix is made by Sanofi/BMS; Deplatt is the Torrent Pharma brand. The two are bioequivalent generics of the same molecule.

Can I drink alcohol on Deplatt?

Moderate alcohol is acceptable. Heavy or binge drinking raises GI bleeding risk and is best avoided.

How long do I take Deplatt?

Indefinitely for secondary stroke/TIA or PAD. After ACS or stenting the DAPT phase is typically 6-12 months, then often clopidogrel monotherapy continues indefinitely if aspirin-intolerant. Your cardiologist sets the duration.

Where can I buy Deplatt online?

You can buy Deplatt (75 mg clopidogrel, 30-90 tablets) from MedsBase with discreet packaging and worldwide shipping.

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